VICTOR M. PEREZ ALVAREZ

**** **** ***** ***** *** 219 Baltimore MD, 21217

443-***-****, 443-***-****

acry2j@r.postjobfree.com

Experience

Post-Doctoral Fellow

Johns Hopkins School of Medicine, Pathology Department.

2014-2015 (October to June)

Developing and validating a new LC MS/MS method to determine simultaneously 6 different Tyrosine Kinase Inhibitors in patient’s plasma.

Professional Associate

University of Manitoba Department of Internal Medicine and Pharmacology and Therapeutics

2013 – 2015 (December - April)

Design, synthesis and evaluation of analogs of tamoxifen for the treatment of cholangiocarcinoma.

Research Associate

Department of Chemistry

2012-2013 (March to October)

Synthesis of permanent charged pyridine quaternary ammonium salts’ compounds to tag carbohydrates and their determination using MALDI – TOF mass Spectrometry.

Lecturer, Chemistry 1300.

2012 (September to December )

Teaching of a University Chemistry course for 150 students.

Professor

National Polytechnic Institute (CINVESTAV), Pharmacology Department

1987- 2012 (January –May)

Principal Investigator of a Medicinal Chemistry laboratory, Master’s and PhD students’ supervisor. Teaching Organic chemistry and Pharmacology to postgraduate students

Coordinator of Academic Affairs

2005- 2008 (June – September)

Coordinate all the academic activities of 100 post graduate student and 12 professors of the Pharmacology Department.

Education

National Polytechnic Institute (CINVESTAV)

September 1981 – May 1997

PhD degree: "Pharmacology.", May 1997.

PhD. Studies: “Organic Chemistry” June 1995

Master of Science degree: "Pharmacology". October 1985

Mexico City (Mexico)

National Polytechnic Institute (ENCB)

September 1976 – July 1981

Bachelor degree: "Pharmaceutical and Industrial Chemistry." July 1981

Selected Publications (total of 36 refereed publications)

http://www.ncbi.nlm.nih.gov/pubmed/?term=Perez-Alvarez+v.)

1.Bautista W, Perez-Alvarez V., Burczynski F, Raouf A., Klonisch T, Minuk G. Membrane Potential Differences and GABAA Receptor Expression in Hepatic Tumor and Non-tumor Stem Cells. Can J Physiol Pharmacol. 2014; 92: 85-91

2.Rivera-Guevara C, Pérez-Alvarez V, García-Becerra R, Ordaz-Rosado D,Morales-Ríos MS, Hernández-Gallegos E, Cooney AJ, Bravo-Gómez ME, Larrea F,Camacho J. Genomic action of permanently charged tamoxifen derivatives via estrogen receptor-alpha. Bioorg Med Chem. 2010; 18(15):5593-601.

3.Rivera-Becerril E, Joseph-Nathan P, Pérez-Álvarez VM, Morales-Ríos MS. Synthesis and Biological Evaluation of - and -Debromoflustramine B and its analogues as Selective Butyrylcholinesterase Inhibitors. J Med Chem.51 (17):5271-84, 2008.

4.Fernández-Martínez E., Morales-Ríos Martha S., Pérez- Álvarez V., Muriel P. Immunomodulatory effect of thalidomide analogs on LPS-induced plasma and hepatic cytokines in the rat. Biochem. Pharmacol.; 68: 1321-9, 2004.

5.Pérez-Alvarez V., Morales-Ríos M. S., Hong E. and Joseph-Nathan P. Synthesis and preliminary cardiovascular evaluation of 3-amino-2-(3 indolyl)propanol and propanoate derivatives. J. Pharm. Pharmacol.; 49:246-252, 1997.

6.Muriel P., Garciapiña T., Pérez-Álvarez V., Mourelle M. Silymarin protect paracetamol induced lipid peroxidation and liver damage. J. Appl. Tox.; 12(6): 439-442, 1992.

7.Mourelle M., Amezcua J.L., Pérez-Alvarez V. Reduction of apparent indicators of liver cirrhosis by arachidonate lipoxygenase inhibitor BW755C. European Journal of Pharmacology; 134: 175180, 1987.

Languages and Technologies

I am fluent in English and Spanish (native tongue)

I can understand, speak, read and write very well in both languages.

I am an experienced user of Microsoft Office package, some common statistics, chemistry draw and HPLC, NMR and Mass spectrometry programs, as Xcalibur package software for e.g.

Additional achievements

Book Chapters

1. Pérez-Alvarez V. “Liver role on drug metabolism.” Current concepts on hepatology; Méndez-Sanchez N. y Uribe M. Eds. Masson Doyma México, S.A. pags 53-62, 2003.

Posters presented in International Meetings: 24

Thesis directed.

PhD Thesis: 5

Master in Science Thesis: 5

Distinctions

Research Professor, Level I

Mexico, CONACYT National Research Council.

Since 1994.-2012

Candidacy for Researcher.

Mexico, CONACYT National Research Council.

1988-1994.

Recipient of five grants by the National Council of Science and Technology of Mexico, CONACYT (1998-2009)

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