ZHENGMAO HUA

***** ******* **. **** *****. CA ***07

Cell: 319-***-****, E-mail: acruot@r.postjobfree.com

PROFESSIONAL EXPERIENCE

Senior Research Chemist

Waters Corporation (Davis Companies) Aug. 2013 - Jun. 2015

Waters Corporation (Milford, MA, Assigned by Davis companies)

Perform wet chemistry to prepare compounds for the analytical chemistry procedure

Initiate, prepare and review quality control procedure for Project Candy Crush

Develop and validate new analytical methods for compliance with cGMP

Develop of UPC2 Torus HPLC chromatography columns for the purification of a range of different compounds

Design and optimize of safe scalable synthetic routes for mass spectrum-sensitive glycoprotein tagging chemicals for HPLC-MS analysis

Research Associate Nov. 2007 - Aug. 2013

University of Massachusetts Medical School

Develop highly potassium sensitive and selective fluorescent compounds

Design and synthesize novel small molecule probes for chemical biology study

Identification of organic compounds using NMR, MS and FTIR

Develop the purification method for the protein-small molecule complex using ion exchange columns and

HPLC instrument

Graduate Research Assistant 2001 - 2007

The University of Iowa

Carried out the synthetic studies toward the total synthesis of Superstolide A, a potential anti-cancer agent.

Completed the construction of cis-Decalin portion of Superstolide A

Discovered a methodology for the stereo-controlled synthesis of substituted [2,2,2]-octanes

Improved the procedure for the separation of or -isopinocampheol, the major side product of the

oxidation workup procedure of Brown’s asymmetric crotylboranate reactions

EDUCATION

PhD, Organic Chemistry, The University of Iowa, Iowa City, IA Year 2006

MS, Organic Chemistry, East China Normal University, Shanghai, China Year 1997

PUBLICATIONS

Rapid Preparation of Released N-Glycans for HILIC Analysis Using a Labeling Reagent that Facilitates Sensitive Fluorescence and ESI-MS Detection Lauber, M.; Yu, Y.; Brousmiche, D.; Hua, Z.; Koza, S.; Magnelli, P.; Guthrie, E.; Taron, C. and Fountain K. Analytical Chemistry 87 (10), 2015, 5401-5409

Functionalization and Purification of Peptide-toxin Probes for Ion Channels Methods in Molecular Biology:

Chemical Neurobiology Protocols Humana Press, Hua, Z. and Kobertz, W. 995, 2013, 19-30

Chemical control of metabolically-engineered voltage-gated K channels Hua, Z.; Lvov, A.; Morin, T.;

Kobertz, W. Bioorganic & medicinal chemistry letters. 2011, 21, 5021-5024

Controlling the Facial Selectivity of Asymmetric [4 + 2] Cyclo-additions: A Concise Synthesis of the cis-

Decalin Core Structure of Superstolides A and B. Chen, L., Hua Z., Li, G., Jin, Z. Org. Lett. 2011, 13,

3580-3583

Nascent Peptide Side-chains Induce Rearrangements in Distinct Locations of the Ribosomal Tunnel Lu, J.; Hua, Z.; Kobertz, W.; Deutsch, C. Journal of Molecular Biology 2011, 411(2), 499-510.

Highly Facial and Stereo-selective Diels-Alder Reactions Employing 1, 3-Dienes Derived from R-4-

Hydroxy-2-Cyclohexenone, Hua, Z.; Chen, L.; Mei, Y. and Jin, Z. Tetrahedron Lett. 2009, 50, 6621-6623

An Improved Procedure for the Separation of or -Isopinocampheol, the Major Side Product of

Brown's Asymmetric Crotylboranate Reactions, Hua, Z.; Jin, Z. Tetrahedron Lett. 2007, 48, 7695-7697

Synthetic Studies Toward the Construction of the cis-Decalin Portion of Superstolide A and B. Application

of a Sequential Double Michael Reaction and an Anionic Oxy-Cope Rearrangement, Hua, Z.; Yu, W.; Su,

M., Jin, Z. Org. Lett. 2005, 7, 1939-1942

Improved Procedure for the Oxidative Cleavage of Olefins by OsO4-NaIO4, Yu, W.; Mei, Y.; Kang, Y.;

Hua, Z.; Jin, Z. Org. Lett. 2004, 6, 3217-3219

Negishi Coupling between α-Alkyl(aryl)thio Vinyl Zinc Chloride and α -Bromo Vinyl Ether: A

Convergent Synthesis of 2-Alkoxy-3-alkyl(aryl)thiobuta-1, 3-dienes, Su, M.; Kang, Y.; Yu, W.; Hua, Z.;

Jin, Z. Org. Lett. 2002, 4, 691-694

Process for Preparing Adrenaline beta-Agonists by Combinatorial Resolution Method CN19991017313

Deng, J.; Peng, X.; Hua, Z.; Wu, T.; Yang, L.; Chinese Patent

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