R O Z H I N P E N J W E I N I

E D U C AT I O N

C A R E E R S U M M A R Y

**** ******* ***., ********* ***,

Philadelphia PA 19143, USA.

acrej1@r.postjobfree.com

Mobile: +1-215-***-****

PERSONAL INFORMATION

Born in January 1982

Speak Kurdish (mother tongue),

Persian (fluently),

English (fluently) and

German (intermediate level )

REFERENCES

Prof. dr. Marcel Ameloot

Hasselt University, Biomedical

Research Institute (BIOMED)

Biophysics Research Group

Agoralaan Building C

3590 Diepenbeek, Belgium.

Phone: +32-11 26 92 33

e-mail: acrej1@r.postjobfree.com

Prof. dr. Karl W. Kratky

University of Vienna, Faculty of

Physics, Boltzmanngasse 5

A-1090 Vienna, Austria.

Phone: +43-1 4277 51196

e-mail: acrej1@r.postjobfree.com

Dr. Saiedeh Saghafi

Vienna University of Technology

Department of Bioelectronics

Floragasse 7, 1040 Vienna, Austria

&

Medical University of Vienna

Center for Brain Research

Spitalgasse 4

1090 Vienna, Austria.

Phone: +43-1 588**-*****

Doctoral program in Physics

University of Vienna, Physics

Department, Physics of Physiological

Processes,

Vienna, Austria

Postdoctoral researcher

Hasselt University, Biomedical

Research Institute (BIOMED),

Biophysics Research Group

Diepenbeek, Belgium

Master program in Applied Physics

Islamic Azad University (IAU)

Research and Science Campus

Plasma Physics Research Center

Biophotonics Laboratory

Tehran, Iran

Project assistant

Vienna University of Technology,

Bioelectronics department,

Vienna, Austria

Bachelor program in Solid State Physics

Zanjan University, Physics Department

Zanjan, Iran

Research assistant

Islamic Azad University (IAU)

Research and Science Campus

Plasma Physics Research Center,

Tehran,Iran

2009 - 2012

2012 - 2014

2005 - 2007

2011 - 2012

2000 - 2004

2007 - 2008

Thesis title: Biophysical investigation of photosen- sitizer PVP-Hypericin and its tumor therapeutic

efficiency: sequential monitoring of specific cell ensembles by use of controlled photoexcitation

imaging methods.

PhD advisor: Prof. Dr. Karl W. Kratky

October 2012; PhD was completed with

distinction.

Contributed to following project:

Development of label free imaging and dvanced

fluorescence microscopy methods for studying

the intracellular localization, transport and stability of nanomedicines for cancer therapy.

Supervision of 9 master and bachelor

theses.

Thesis title: Investigating the effects of polychro- matic and monochromatic beams on annihilation

of fungus (Moulds and Candida) using spectrop-

hotometry analysis.

MSc. advisor: Dr. Saiedeh Saghafi

December 2007; Graduated as one of the

top 10% ranked students.

Contributed to the following project:

Effects of UV-, Visible-, Near-infrared beams in

three therapy resistance case studies of fungal

skin infections.

Thesis title: Characterizing the concentration of

natural and man-made nanoparticles in the air

pollution of of Sanandaj (a city in Iran)

July 2004; Graduated as one of the top 10%

ranked students.

Contributed to following project:

Investigating the variation in optical parameters

of diabetic blood samples treated with low level

lasers compared with the normal samples.

Tutor and lab demonstrator in:

Laser-Medicine workshop organized by Clinical

Center of Laser Medicine of Russian State and

IAU.

Postdoctoral researcher

University of Pennsylvania,

Department of Radiation Oncology,

Philadelphia, USA

2014 - PRESENT

Contributed to following project:

Explicit dosimetry for photodynamic therapy

(PDT) of cancer: macroscopic and microscopic

singlet oxygen modeling.

Deformable image registration for pleural PDT.

R O Z H I N P E N J W E I N I

P U B L I C AT I O N S

2014

Two-year fellowship, co-finan-

ced by the Marie Curie Pro-

gram of the European Union,

to excellent post-docs at an

early stage in their career from

the University of Bremen, Ger-

many.

Funding proposal title: Engi-

neered therapeutic biocom-

patible nanocarriers for living

cells.

2013

Fully funded access to na-

no-characterization facilities

across Europe from the Eu-

ropean Union-funded in-

frastructure for quality in

nanomaterials safety testing

(QualityNano).

2013

A.T. Kearney Scholarship for

the Falling Walls Lab and Con-

ference, Berlin, Germany.

2008

Enrollment in the Ph.D pro-

gram without entrance exam

due to the graduation from

master program as a top 10%

ranked student.

1. R. Penjweini, S. Deville, L. D’Olieslaeger, M. Berden, M. Ameloot, A. Ethirajan. Intra- cellular localization and dynamics of Hypericin loaded PLLA nanocarriers in A549 cancer cells by image correlation spectroscopy. Journal of Controlled Release 2015; (Under Review).

2. R. Penjweini, B. Liu, M.M. Kim, T.C. Zhu. Explicit dosimetry for HPPH mediated pho- todynamic therapy: macroscopic singlet oxygen modeling. J. Biomedical Optics 2015;

(Under Review)

3. S. Deville, R. Penjweini, N. Smisdom, K. Notelaers, I. Nelissen, J. Hooyberghs, M. Ameloot. Intracellular dynamics and fate of polystyrene nanoparticles in A549 lung epithelial cells monitored by image (cross-) correlation spectroscopy and single particle tracking. Biochimica et. Biophysica Acta 2015; 1853: 2411-2419. 4. T.C. Zhu, B. Liu, R. Penjweini. Study of tissue oxygen supply rate in a macroscopic PDT singlet oxygen model. J. Biomedical Optics 2015; 20 (3):038001 5. R. Penjweini, N. Smisdom, S. Deville, M. Ameloot. Transport and accumulation of PVP-Hypericin in cancer and normal cells characterized by image correlation spectros- copy techniques. Biochimica et Biophysica Acta 2014; 1843:855-865. 6. R. Penjweini, H-G. Loew, P. Breit, K.W. Kratky. Optimizing the antitumor selectivity of PVP-Hypericin re A549 cancer cells and HLF normal cells through pulsed blue light. Photodiagnosis and Photodynamic Therapy 2013; 10:591-599. 7. R. Penjweini, S. Mokmeli, K. Becker, H-U. Dodt, S. Saghafi. Effects of UV-, Visible-, Near-infrared beams in three therapy resistance case studies of fungal skin infections. Optics and Photonics Journal 2013; 3:1-10.

8. R. Penjweini, H-G. Loew, M. Eisenbauer, K.W. Kratky. Modifying excitation light dose of novel photosensitizer PVP-Hypericin for photodynamic diagnosis and therapy. J. Photochemistry and Photobiology B: Biology 2013; 120:120-129. 9. R. Penjweini, H-G. Loew, M. R. Hamblin, K. W. Kratky. Long-term monitoring of live cell proliferation in presence of PVP-Hypericin: a new strategy using ms pulses of LED and the fluorescent dye CFSE. J. Microscopy 2012; 245:100-108. 10. S. Saghafi, R. Penjweini, K. Becker, K.W. Kratky, H-U. Dodt. Investigating the effects of laser beams (532nm and 660nm) in annihilation of pistachio mould fungus using spectrophotometry analysis. J. European Optical Society Rapid Publications 2010; 5:100325.

1. R. Penjweini, B. Wilson, T.C. Zhu. Spectroscopic imaging in prostate PDT. Elsevier’s

(Submitted 2015)

2. R. Penjweini, S. Deville, A. Ethirajan, M. Ameloot. Nanoscience and Dermatology. Investigating the intracellular dynamics of Hypericin loaded nanoparticles by image cor- relation spectroscopy. Elsevier’s (Submitted 2015) 3. T.C. Zhu, M.M. Kim, S.L Jacques, R. Penjweini, A. Dimofte, J.C. Finlay, C.B. Simone, K.A. Cengel, J. Friedberg. Real-time treatment light dose guidance of Pleural PDT: an update. Proc. SPIE 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV, 930809, 2015. 4. R. Penjweini, M.M. Kim, T.C. Zhu. In-vivo outcome study of HPPH mediated PDT using singlet oxygen explicit dosimetry (SOED). Proc. SPIE 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV, 93080N, 2015.

5. M.M. Kim, R. Penjweini, T.C. Zhu. In-vivo outcome study of BPD-mediated PDT using the macroscopic singlet oxygen model. Proc. SPIE 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV, 93080A, 2015.

6. R. Penjweini, T. C. Zhu. Updated results of singlet oxygen modeling incorporating local vascular diffusion for PDT. Proc. COMSOL, Bioscience and Bioengineering, USA 2014. JOURNAL PAPERS

BOOK CHAPTERS & CONFERENCE PROCEEDINGS

AWARDS

R O Z H I N P E N J W E I N I

TECHNICAL SKILLS

COMPUTER SKILLS

- International computer driving license

- Softwares for Simulations, Modelings

and Image Analyzing:

ImageJ - HiPic - Amira - MATLAB -

COMSOL Multiphysics -Adobe InDesign-

Adobe Photoshop

- Softwares for Optical System Designing:

Wolfram Mathematica - Zymax

- Softwares for Statistics:

SPSS - Igor Pro

LABORATORY SKILLS

- In vitro: Cancer cell culture

- In vivo: Mice study

MICROSCOPY AND SPECTROSCOPY

TECHNIQUES

- rence Phase Contrast Contrast Microscopy and Dfferential

- Fluorescence and Confocal Microscopy

- UV-Visible-IR Spectrophotometry

- Fluorescence Spectroscopy

- Fluorescence Correlation Spectroscopy

(FCS)

- Image Correlation Spectroscopy (ICS)

- Image Cross-correlation Spectroscopy

(ICCS)

- Raster-Scanning Image Correlation

Spectroscopy (RICS)

- Fluorescence bleaching (FRAP) Recovery After

- Fluorescence Resonance Energy Transfer

(FRET)

- Fluorescence Lifetime Imaging (FLIM)

- Single Particle Tracking (SPT)

1. R. Penjweini, T.C. Zhu. Finite element-based deformable image regist- ration of pleural cavity for photodynamic therapy. 57th Annual Meeting & Exhibition, Anaheim, CA, USA 2015.

2. M.M. Kim, R. Penjweini, T. C. Zhu. Determination of light fluence inside a pleural cavity. 15th International Photodynamic Association World Congress, IPA, Rio de Janeiro Brazil 2015; IPA045

3. R. Penjweini, N. Smisdom, S. Deville, M. Ameloot. Intracellular transport of photosensitizer PVP-Hypericin characterized by image correlation spectrosco- py techniques. Proc. of the FOM conference, Maastricht, Netherland 2013; 307. 4. S. Deville, N. Smisdom, R. Penjweini, I. Nelissen, J. Hooyberghs, M. Ameloot. Intracellular nanoparticle dynamics investigated by image correlation spec- troscopy. Proc. of the FOM conference, Maastricht, Netherland 2013; 358. 5. S. Deville, N. Smisdom, R. Penjweini, I. Nelissen, J. Hooyberghs, M. Ame- loot. Intracellular nanoparticle dynamics investigated by image correlation spectroscopy. Proc. of the 2nd QNano Integrating Conference, Prague, Czech Republic 2013.

6. R. Penjweini, K.W. Kratky, H. U. Dodt, S. Saghafi. Characterizing the effects of coherent laser beams and non-coherent LED beams on annihilation of bread mould fungus. Proc. of the EOS Topical Meetings, Capri, Italy 2011; 80. 7. R. Penjweini, H-G. Loew, K.W. Kratky. Illumination using pulsed LED redu- ces phototoxicity and photobleaching in fluorescence imaging of living cells. Proc. of the 11th Biennial ESTRO Conference on Physics and Radiation techno- logy for Clinical Radiotherapy, London, UK 2011; 99:433. 8. R. Penjweini, H-G. Loew, M. Eisenbauer, P. Breit, K.W. Kratky. Fluorescence live cell imaging of A549 cells in presence of PVP-Hypericin: modifying excita- tion light dose of blue LED. Proc. of the 8th European Biophysics Congress, Budapest, Hungary 2011; 40:152.

9. S. Saghafi, R. Penjweini, M. Ghoranneviss, H-U. Dodt. Investigating the effects of flat-top laser beams (532 and 660 nm) in annihilation of pistachio mold fungus using spectrophotometry analysis. Proc. of the EOS Topical Mee- tings, Capri, Italy 2009.

10. S. Saghafi, F. Kashef, S. Mokmeli, H. Hosseini, R. Penjweini. Combined wa- velengths of low level lasers an effective approach in scar healing. Proc. of the World Association of Laser Therapy (WALT), Sun City, South Africa 2008; 184. ABSTRACTS OF POSTER PRESENTATIONS

ABSTRACTS OF TALKS

1. R. Penjweini, M.M. Kim, T.C. Zhu. In-vivo outcome study of HPPH mediated PDT using singlet oxygen explicit dosimetry (SOED). SPIE. PHOTONICS WEST, San Francisco, California, USA 2015;103.

2. R. Penjweini, M. M. Kim, T. C. Zhu. Updated results of singlet oxygen modeling incorporating local vascular diffusion for PDT. COMSOL Conference, Boston, USA 2014.

3. R. Penjweini. Breaking the wall of cell-based drug delivery. International Falling Walls Lab, Berlin, Germany 2013.

4. R. Penjweini, H-G. Loew, M. Eisenbauer, P. Breit, K. W. Kratky. Fluorescence imaging of living A549 cells combined with HLF cells: reducing PVP-Hypericin side effects on HLF cells by modifying excitation light dose of pulsed blue LED. Proc. of the 14th Congress of the European Society for Photobiology, Geneva, Switzerland 2011; 90.

5. R. Penjweini, F. Mohajer, A. Geranmayeh, K.W. Kratky, S. Saghafi. Charac- terizing the effects of combinations of visible-infrared laser beam and blue/ red-LED-arrays on albicans candida and pityriasis versicolor destruction. Proc. of the 60th Annual Meeting of the Austrian Physical Society, Salzburg, Austria 2010; 126.

6. S. Saghafi, F. Kashef, S. Mokmeli, H. Hosseini, R. Penjweini. Investigating the variation in optical parameters of low level lasers in diabetic blood samp- les compared with the normal samples. Proc. of the World Association of Laser Therapy (WALT), Sun City, South Africa 2008; 95.

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