Resume

Lawrence J. Mulligan, PhD, FAHA

Address: Home: 24530 Gosling Rd, #1428

Spring, Tx 77389

(C) 763-***-****

acrdwf@r.postjobfree.com

SUMMARY

Medical Science Liaison, Strategic Leader, Technical Expert, Director with expertise that includes:

Expert in cardiovascular disease including heart failure, lipidology, with training in COPD and cardiopulmonary.

Developed worldwide relationships with more than 70 KOLs

Designed and led clinical trials providing Medtronic with clinical evidence for product development, marketing resources and protection of market share.

oManaged programs containing 20 PI’s and 50 KOLs which led to 4 published studies and 7 published abstracts.

Led 6 advisory boards supporting product development and clinical trial design.

Created 4 educational programs for targeted Medtronic and customer audiences.

Experince in cath-lab (12 years) and surgical OR (5) enviroments.

Partnered with 10 physician customers to gather information to support critical initiatives.

Led group that published 4 studies (cited 80 x) supporting product features and 13 (cited 210 x) pre-clinical studies that supported fundamental and applied research.

Medical liaison responsibilities.

Awarded 13 patents.

Led group that developed an innovative leadership and engagement program.

Academic: Adjunct Professor at 3 universities serving on 4 M.S and PhD committies.

3/15-8/15: Amgen, Regional Medical Liaison

Responsible for supporting the Cardiovascular Therapeutic Area, including the heart failure drug (Corlanor) and

the PCSK9 inhibitor (Evolocumab, under review at the FDA)

12/14-3/15: Respiratory Dyspnea Clinic (Brigham and Woman’s Hospital)

Under the direction of Dr David Systrom, I was responsible for evalauting patient data from pulmonary function testing and

Level III CPX testing to determine if maximal and submaximal testing provided similar insights in patients..

4/13 to 5/14: Abiomed, Director of Clinical Affairs

Responsible for development of 2 manuscripts and PMA literature review for submission to FDA to extend device labelling. Met with 10 physicians that had submitted research proposals.

4/12-3/13: CV Solutions, Consultant

Consultant for 4 medical device companies, range of responsibilities including development of clinical

evidence, educational material and creation of clinical trial and business plan.

6/04-4/12: Medtronic, Inc-Therapy Delivery Division, Senior Principal Scientist, Technical Fellow,

Medical Affairs Liaison, Led pre-clinical and clinical Physiologic Research Group,

12/02- 6/04: Principal Clincial Study Manager, RESOLV-MI Clinical Trial, Heart Failure Management.

1/99-12/02: Principal Scientist, Pre-clinical heart failure research

1994-1998: Deborah Heart and Lung Center: Asst Prof, Senior Research Associate, pre-clinical activity

1993-1994: Univ of Penn: Asst Prof of Radiologic Science and Physiology, pre-clinical activity

1991-1993: UTHSC-SA/Cardiology: Post doctoral fellow and Clinical Instructor, pre-clinical activity

Education

1977-81: B.S. Villanova University (Business Administration)

1985-88: M.S. Texas A&M University, Exer Physiology

1988-91:Ph.D Texas A&M University, College of Veterinary Medicine, Cardiac and Systems Physiology

2010-11: Executive Leadership Certificate Program, Univ of Notre Dame

Awards

7/10, Awarded “Fellow of the American Heart Association” title

10/10, Awarded Medtronic top technical title “Technical Fellow” (this is the top award for indiividuals in the technical track (total number in MDT, 225)

Published Manuscripts

Bose A, Kandala J, Upadhyay G, Ahmado I,Altman R, Riedl L, Mulligan LJ, Singh J. Impact of myocardial viability and left ventricular lead location on clinical outcome in cardiac resynchronization therapy recipients with ischemic cardiomyopathy. J Cardiovasc Electrophysiol. 2014 May;25(5):507-13

Leyva, F, Foley, P, Mulligan, LJ, Patel, K, Prasad, S, Stegemann, B, Smith, M. Mid-wall fibrosis as a

predictor of mortality and morbidity after cardiac resynchronization therapy in patients with non-

ischemic cardiomyopathy. J Am Coll Cardiol. 2012 Oct 23;60(17):1659-67

Nazzal CM, Mulligan LJ, Criscione JC. Efficient characterization of inhomogeneity in contraction strain

pattern. Biomech Model Mechanobiol. 2012 May;11(5):585-93

Howard EJ, Covell JW, Mulligan LJ, McCulloch AD, Omens JH, Kerckhoffs RC. Improvement in pump

function with endocardial biventricular pacing increases with activation time at the left ventricular

pacing site in failing canine hearts. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1447-55.

Kerckhoffs RC, Omens JH, McCulloch AD, Mulligan LJ. Ventricular dilation and electrical dyssynchrony

synergistically increase regional mechanical nonuniformity but not mechanical dyssynchrony: a computational model. Circ Heart Fail. 2010 Jul;3(4):528-36.

Merchant FM, Heist EK, Nandigam KV, Mulligan LJ, Blendea D, Riedl L, McCarty D, Orencole M, Picard

MH, Ruskin JN, Singh JP. Interlead distance and left ventricular lead electrical delay predict reverse

remodeling during cardiac resynchronization therapy. Pacing Clin Electrophysiol. 2010 May;33(5):575-82.

Black A, Ewert D, Mulligan LJ. Decay of postextrasystolic potentiation in the left and right ventricles of

intact canine hearts. Conf Proc IEEE Eng Med Biol Soc. 2009;:2904-6.

Kerckhoffs RC, Campbell SG, Flaim SN, Howard EJ, Sierra-Aguado J, Mulligan LJ, McCulloch AD. Multi

scale modeling of excitation-contraction coupling in the normal and failing heart. Conf Proc IEEE

Eng Med Biol Soc. 2009;2009:4281-2.

Mills RW, Cornelussen RN, Mulligan LJ, Strik M, Rademakers LM, Skadsberg ND, van Hunnik A, Kuiper

M, Lampert A, Delhaas T, Prinzen FW. Left ventricular septal and left ventricular apical pacing

chronically maintain cardiac contractile coordination, pump function and efficiency. Circ Arrhythm

Electrophysiol. 2009 Oct;2(5):571-9

Campbell SG, Howard E, Aguado-Sierra J, Coppola BA, Omens JH, Mulligan LJ Effect of transmurally

heterogeneous myocyte excitation-contraction coupling on canine left ventricular electromechanics.

Exp Physiol. 2009 May;94(5):541-52.

Kerckhoffs RC, McCulloch AD, Omens JH, Mulligan LJ. Effects of biventricular pacing and scar size in a

computational model of the failing heart with left bundle branch block. Med Image Anal. April 2009

Kerckhoffs RC, Narayan SM, Omens JH, Mulligan LJ, McCulloch AD. Computational modeling for

bedside application. Heart Fail Clin. 2008 Jul;4(3):371-8.

Kerckhoff, R Lumens, J, Vernooy, K Omens, JH, Mulligan, LJ, Delhaas, T, Arts, T, McCulloch, AD.

Cardiac resynchronization: Insight from experimental and computational models. Prog Biophys Mol Biol. 2008 Jun-Jul;97(2-3):543-61.

Reinig M, White M, Levine M, Cha R, Cinel I, Purnachandra J, Goldfarb R, Yang Z, Mulligan LJ.

Parrillo J, Gessman L. Left ventricular endocardial pacing: a transarterial approach. Pacing Clin Electrophysiol. 2007 Dec;30(12):1464-8.

Handahl, S, Ripplinger, C., Skadsberg, N Iazzu, P, Mulligan, LJ. Effects of Pacing Rate on

Mechanical Restitution within the In Vivo Canine Heart: Study of the Force-Frequency Relationship. Cardiovasc Eng. 2007 Sep;7(3):89-96

Ahlberg, S Hamlen, R, Ewert, D, Iaizzo, P, Mulligan, LJ. Novel Means to Monitor Cardiac

Performance: The Impact of the Force-frequency and Force-interval Relationships on

Recirculation Fraction and Potentiation Ratio. Cardiovasc Eng. 2007 Mar;7(1):32-8

Ahlberg, Grenz, N Ewert, D, Iaizzo, P, Mulligan, LJ. Effect of Pacing Site on Systolic Mechanical

Restitution Curves in the In Vivo Canine Model. J Cardiovasc Electrophysiol. 2007 Feb;18(2):212-7

Patents Awarded

6,438,408, Implantable medical device for monitoring congestive heart failure

6,738,667, Implantable medical device for treating cardiac mechanical dysfunction by electrical stimulation

6,810,286, Stimulation for delivery of molecular therapy

6,865,419, Method and apparatus for measurement of mean pulmonary artery pressure from a ventricle in an ambulatory monitor

6,915,157, Implantable medical device for assessing heart failure state from Mechanical Pulsus Alternans

6,994,676, Method and apparatus for assessing ventricular contractile status

7,079,887, Method and apparatus for gauging cardiac status using post premature heart rate turbulence

7,130,684, Method and apparatus for improving ventricular status using the force interval relationship

7,289,850, System for enhanced cardiac function with combined PESP/NES

7,292,888, Cardiac stimulation during a refractory period

7,792,581, Method and apparatus for treating diastolic heart failure

Postgraduate Training and Fellowship Appointments:

1991-1993: NIH Post-doc Fellow Univ Texas Health Science Center at San Antonio, Department of

Cardiology

Academic Appointments:

2002-present: Adjunct Professor, North Dakota State Univ, Dept of Computer and EE;

2009-12: Adjunct Professor, Texas A&M, Dept of Biomedical Engineering;

2007-2012: Adjunct Professor, Univ of California at San Diego, Dept of Biomedical Engineering

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