Pranab Kumar Mishra, Ph.D.

(US Citizen)

**** ******* *****, *******, ** 18966

Ph. 858-***-****(Cell)

858-***-**** Home)

acqwem@r.postjobfree.com

Highly motivated individual seeking a challenging position where my strong knowledge and experience in drug discovery can be utilized

CAREER HIGHLIGHTS

• Extensive experience in hit-to-lead and lead-optimization efforts in drug discovery area of infectious diseases/ oncology/ metabolic diseases/ auto-immune/ Toll-like receptors

• Synthetic chemist and Project leader in metabolic disease program.

• Strong decision making skills

• Knowledge in advancing a compound to development in Rheumatoid arthritis program

• Knowledge of SOPs for GMP laboratory skills

• Completed five day Patent Bar exam review course from PLI (Practicing Law Institute)

• Strong track record of achievement in design, synthesis, purification and characterization of complex drug-like molecules

• Hands on experience on chemistry instrumentations: HPLC, NMR, IR, LC/MS, UV, GC/MS, ISCO and Biotage normal-phase purification, microwave synthesizers, etc.

• Hands-on experience on synthetic process development in multi-gram scale and lab studies on stability testing, solubility and degradation studies

• Expertise in understanding and addressing difficult ADME/PK issues

• Design and execution of work for a timely delivery of project objectives

• Experience in interfacing with CRO companies

• Excellent written and oral communication skills, strong interpersonal skills, with excellence in innovation, problem-solving and leadership

• Experience in interacting effectively with members of multidisciplinary teams on a cross-functional basis, presentation of team work in front of higher-level committees

• Self-motivated, flexible and open to new ways of working and improving

• Experience in mentoring and development of junior scientists at Tanabe and GNF and of graduate and postdoctoral students at Stanford, Montana State University and Stony Brook University (SUNY at Stony Brook)

PROFESSIONAL EXPERIENCE

The Chemistry Research Solution LLC, Bristol, PA 19007 Oct 2014 - Present

• Synthetic Chemist in the teams for Anti-body drug conjugate research. Synthesis of PBD dimer analogs that involves more than fifteen steps.

• Synthesis of fluorescent probe analogs for anti-body drug conjugates

Genomics Institute of the Novartis Research Foundation, San Diego, CA June 2007 – February 2013

Investigator (Promoted in 2010)

• Medicinal Chemist in the teams for Anti-Leishmania /Anti-Malaria /Vaccine-Adjuvant/ Oncology/Auto-immune disorder disease areas

• Hit-to-lead and lead optimization for Anti-malarial and Anti-Leishmania project, working in parallel on multiple scaffolds to determine best candidates

• Generation of proof-of- concept compounds for in vivo efficacy testing for four distinct series that meet key criteria for in vitro potency and oral exposure for the anti-malaria project

• Introduction of chemical functionalities to dramatically improve oral PK properties and cellular selectivity for pathogens over mammalian cells. Utilization of difficult synthetic chemistry for making enantiopure analogs. One of the scaffolds was transitioned to pre-clinical development in the anti-malaria project

• Helped to progress for design and synthesis of specific targeted analogs in one scaffold which showed significant improvement in mouse efficacy over the current drugs in the market for Leishmaniasis; subsequently this scaffold was transitioned to full lead optimization and was key person in bringing rest of the chemistry team up to speed on SAR, SPR, and synthesis model evaluation

• Currently this compound is at the final stage of CSP (compound selection process) declaration in the anti-leishmania project

• Invention of one of the preclinical drug candidates for use as a vaccine adjuvant. Invention of Topical SMIP-7.7, a toll-like receptor 7 agonist, that protects against genital herpes simplex virus-2 disease in the guinea pig model of genital herpes

• Efficient SAR optimization and synthesis of new chemical entities to dramatically improve the ADME/PK properties and biochemical/cellular selectivity for compounds during systematic SAR studies or lead optimization for all the projects sometime in parallel

• Auto-immune disease area: Used parallel chemistry, made a focus library to increase solubility and PK profiles

• Auto-immune disease area: Helped to establish & consolidate IP position, lower cLogP within reasonable activity, decrease protein binding, improve solubility

Tanabe Research Laboratories, San Diego, CA April 2002 – Nov 2006

Senior Research Scientist (Promoted in 2005)

• Project Leader and medicinal chemist driving an anti-Obesity/metabolic disease project.

• Synthesized potent selective orally bioavailable inhibitor for the treatment of obesity. Identified the lead compound with potent in vitro activity (low single digit nM range), good selectivity, Oxymax profile, inhibition of fatty acid and TG synthesis, reduction of tissue MCA content and increased FAO, favorable PK/ADME profile (in both rat and mouse), in vivo efficacy, good toxicology profile and safety pharmacology profiles with excellent metabolic stability

• Coordinated and laid out project plans and synthetic routes for the chemistry group. Synthesized reference compounds and lead compounds in multi-gram quantities

• Medicinal chemist for a growth factor receptor antagonist project for the treatment of rheumatoid arthritis

• Identified potent selective orally bio-available growth factor receptor antagonists for the treatment of rheumatoid arthritis.

• High throughput synthesis of a focus library provided a quick access to high quality chemical leads.

• Rational molecular scaffold design guided by SAR studies led to the invention of the desired efficacious compound in vivo

• Medicinal chemist for the Store Operated Calcium Ion Channel Program

• Synthesis of a focus library via rational SAR

• Identified potent selective orally bio-available Store Operated Calcium Ion Channel inhibitor for auto-immune/inflammatory disorders

• High throughput synthesis of a focus library was synthesized for providing a quick access to high quality chemical leads.

• Identified a compound via lead optimization with low nM potency, in-vitro enzyme inhibitory activity, ex-vivo activity, favorable PK/ADME properties and safety and toxicology profiles

EDUCATION

• Ph.D, Organic Chemistry, Montana State University - Bozeman, Montana

Research Advisor: Prof. Cynthia K. McClure, 1997

Dissertation Title: “Synthetic Studies toward the Preparation of Phosphonate Analogs of Sphingolipids.”

• M.A. Organic Chemistry, University of Delaware - Newark, Delaware, Research Advisor: Prof. Cynthia K. McClure, 1995

• M.Tech. Plastics and Rubber Technology (Currently Polymer Science and Technology), University of Calcutta, Kolkata, W.B. India, 1987

Research Advisor: Prof. Premomoy Ghosh

Dissertation Title: “Preparation of reactive and non-reactive polyamide resins for coating applications.

• B.Sc. (Hons) Chemistry, University of Calcutta, Kolkata, West Bengal, India, 1983

REFERENCES

Available Upon Request

PRANAB KUMAR MISHRA: RESUME ADDENDUM

PROFESSIONAL MEMBERSHIPS, AWARDS AND HONORS

Member, American Association for the Advancement of Science

Member, American Chemical Society

Member, San Diego Regulatory Affairs Network (SDRAN)

NIH Fellowship, Stanford University and Stony Brook University

NSF Fellowship, University of Delaware and Montana State University-Bozeman

Senior Research Fellowship, Indian Institute of Technology, Kharagpur, India

Council of Scientific and Industrial Research M. Tech Fellowship from Government of India. New Delhi, India

Ex-member: Indian Institute of Engineers, Calcutta, India

PROFESSIONAL DEVELOPMENT AND TRAINING

Postdoctoral Fellow

2000-2002

R.W.Johnson Pharmaceutical Research Institute, Raritan, New Jersey

Research Advisor: Dr. William V. Murray

Senior Vice-President, Drug Discovery

• Development and utilization of an unprecedented intra-molecular Oxo-Diels Alder reaction leading to the synthesis and discovery of heterocycles with complex stereochemistry

• Synthesis of bioactive molecules using Oxo-Diels Alder and Aza-Diels-Alder reactions

Post-doctoral Fellow

1997-2000

Stanford University and Stony Brook University (SUNY)

Research Advisor: Prof. Dale Drueckhammer (In collaboration with Prof. Chaitan Khosla)

• Development of a new route to prepare synthons for synthesis of Co-enzyme A and its analogs, using multiple steps of challenging chemistry

• Synthesis of Acyl-carrier protein analogs (bioactive molecules) for exploration of polyketide synthase pathways.

PROJECT MANAGEMENT AND OTHER TRAINING

Project Leader: Metabolic Disease Program, 2004-2006, Oversaw the project for a group of 12 chemists and biologist combined, Tanabe Research Laboratories USA Inc.(Currently Mitsubishi Tanabe Pharma)

Project Leader Training Course: 2004, Attended Two Days Intense On-site Course on Project Management, Tanabe Research Laboratories USA Inc. San Diego, CA

Medicinal Chemistry Course: Completed one week Medicinal chemistry course from UCSD, San Diego.

Heterocyclic Chemistry Course: Attended heterocyclic chemistry a two-day course, San Diego, CA

Patent Bar Exam Review Course: Practicing Law Institute, New York, May 13-18th, 2015

OTHER MEETINGS/TALKS ATTENDED

Anatomy Of An Effective Compliance Program: San Diego Regulatory Affairs Network (SDRAN), San Diego, California, USA, 21st November, 2013

Orphan Product Development: Successful Clinical Trials: San Diego Regulatory Affairs Network (SDRAN), San Diego, California, USA, 18th July, 2013

Preparing Investigational New Drug Applications (INDs): American Medical Writer’s Association, San Diego Regulatory Affairs Network (SDRAN), San Diego, California, USA, 20th July, 2013

229th ACS National Meeting: San Diego, California, March 13-17th, 2005.

SELECTED PUBLICATIONS AND PATENTS

• Compounds and compositions for the treatment of parasitic diseases,” Chatterjee, Arnab Kumar; Liang, Fang; Mathison, Casey Jacob Nelson; Mishra, Pranab Kumar; Molteni, Valentina; Nagle, Advait Suresh; Supek, Frantisek; Tan, Liying Jocelyn; Vidal, Agnes; Gelb, Michael Herman; Buckner, Frederick Simmons; Titipaka, Hari Babu; Norcross, Richard, Neil; Gillespie, John, Robert; Pendem, Nagendar. PCT Int. Appl. (2014), WO 2014151630A2.

• Compounds and compositions for the treatment of parasitic diseases,” Chatterjee, Arnab Kumar; Liang, Fang; Mathison, Casey Jacob Nelson; Mishra, Pranab Kumar; Molteni, Valentina; Nagle, Advait Suresh; Supek, Frantisek; Tan, Liying Jocelyn; Vidal, Agnes; Gelb, Michael Herman; Buckner, Frederick Simmons; Titipaka, Hari Babu; Norcross, Richard, Neil; Gillespie, John, Robert. US Pat Appl.published (2014), US 20140275013A1.

• Compounds and compositions for the treatment of parasitic diseases,” Chatterjee, Arnab Kumar; Liang, Fang; Mathison, Casey Jacob Nelson; Mishra, Pranab Kumar; Molteni, Valentina; Nagle, Advait Suresh; Supek, Frantisek; Tan, Liying Jocelyn; Vidal, Agnes; PCT Int. Appl. (2014), WO 2014151729A1.

• Compounds and compositions for the treatment of parasitic diseases,” Chatterjee, Arnab Kumar; Liang, Fang; Mathison, Casey Jacob Nelson; Mishra, Pranab Kumar; Molteni, Valentina; Nagle, Advait Suresh; Supek, Frantisek; Tan, Liying Jocelyn; Vidal, Agnes; US Pat Appl.published (2014), US 20140274926A1.

• Compounds and compositions for the treatment of parasitic diseases,” Jiricek, Jan; Liang, Fang; Mathison, Casey Jacob Nelson; Mishra, Pranab Kumar; Molteni, Valentina; Nagle, Advait Suresh; Supek, Frantisek; Tan, Liying Jocelyn; Vidal, Agnes; Yeh, Vince. PCT Int. Appl. (2014), WO 2014151784A1.

• Compounds and compositions for the treatment of parasitic diseases,” Chatterjee, Arnab Kumar; Liang, Fang; Mathison, Casey Jacob Nelson; Mishra, Pranab Kumar; Molteni, Valentina; Nagle, Advait Suresh; Supek, Frantisek; Tan, Liying Jocelyn; Vidal, Agnes; US Pat Appl.published (2014), US 20140275119A1

• Bin Zou, Advait Nagle, Arnab K. Chatterjee, Seh Yong Leong, Liying Jocelyn Tan, Wei Lin Sandra Sim, Pranab Mishra, Prasuna Guntapalli, David C. Tully, Suresh B. Lakshminarayana, Chek Shik Lim, Yong Cheng Tan, Siti Nurdiana Abas, Christophe Bodenreider, Kelli L. Kuhen, Kerstin Gagaring, Rachel Borboa, Jonathan Chang, Chun Li, Thomas Hollenbeck, Tove Tuntland, Anne-Marie Zeeman, Clemens H. M. Kocken, Case McNamara, Nobutaka Kato, Elizabeth A. Winzeler, Bryan K. S. Yeung, Thierry T. Diagana, Paul W. Smith, and Jason Roland. ACS Med. Chem. Lett., 2014, 5 (8), pp 947–950.

• “Compounds and compositions for the treatment of parasitic diseases,” Chatterjee, Arnab Kumar; Nagle,

Advait Suresh; Paraselli, Prasuna; Kondreddi, Ravinder Reddy; Leong, Seh Yong; Mishra, Pranab Kumar; Moreau, Robert Joseph; Ronald, Jason Thomas; Wei Lin; Sim, Sandra; Simon, Oliver; Tan, Liying Jocelyn; Yeung, Bryan KS; Zou, Bin; Bollu, Venkatataiah. PCT Int. Appl. (2014), WO 2014078802A1.

• “Compounds and compositions for the treatment of parasitic diseases,” Chatterjee, Arnab Kumar; Nagle, Advait Suresh; Paraselli, Prasuna; Leong, Seh Yong; Ronald, Jason Thomas; Mishra, Pranab Kumar; Yeung, Bryan KS; Zou, Ben. PCT Int. Appl. (2014), WO 2014078813A1

• “Compounds and Compositions as TLR activity modulators.” Wu, Tom Yao-Hsiang; Li, Yongkai; Cortez, Alex; Zou, Yefen; Mishra, Pranab; Zhang, Xiaoyue; Skibinski, David; Singh, Manmohan; Valiante, Nicholas. PCT US Appl. (2013), US 8,466,167 B2

• “Topical SMIP-7.7, a toll-like receptor 7 agonist, protects against genital herpes simplex virus-2 disease in the guinea pig model of genital herpes.”Bernstein DI, Cardin RD, Bravo FJ, Earwood J, Clark JR, Li Y, Mishra P, Li C, Nayak BP, Miller AT, Wu TY, Cooke MP, Valiante NM. Antivir Chemistry and Chemotherapy. 2012, Dec.

• “Preparation of phenylimidazole derivatives for use as mPGES-1 inhibitors.” Chianelli, Donatella; Molteni, Valentina; Albaugh, Pamela A.; Choi, Ha-Soon; Loren, Jon; Wang, Zhicheng; Mishra, Pranab. PCT Int. Appl. (2010), WO 201******* A2

• “Compounds and Compositions as TLR activity modulators.” Wu, Tom Yao-Hsiang; Li, Yongkai; Cortez, Alex; Zou, Yefen; Mishra, Pranab; Zhang, Xiaoyue; Skibinski, David; Singh, Manmohan; Valiante, Nicholas. PCT Int. Appl. (2009), WO 200-***-**** A1

• “An intramolecular oxo-Diels-Alder approach to 1-oxo-1,2,3,3a,4,7a-hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl esters.” William V. Murray*, Pranab. K. Mishra, Ignatious J. Turchi, Dorota Sawicka, Amy Maden, Sengen Sun.; Tetrahedron, 2003, 59, (45), 8955-8961.

• “Synthesis of densely functionalized pyrrolidinone templates by an intramolecular oxo-Diels-Alder reaction.” William V. Murray*, Pranab K. Mishra, Sengen Sun, and Amy Maden. Tetrahedron Letters, 2002, 43, (41), 7389-7392.

• “Synthesis of a novel cyclic pentacovalent phosphoenol ether derived from a dienone. Approaches to the syntheses of phosponate analogs of sphingomyelin, sphingosine-1-phosphate and ceramide-1-phosphate.” Cynthia K. McClure* and Pranab K. Mishra.Tetrahedron Letters,2002, 43, (30), 5249-5253.

• “Preparation of densely functionalized pyrrolidine libraries in situ and resin bound via an intramolecular Diels-Alder (IMDA) reaction.” William V. Murray*, Pranab. K. Mishra & Sengen Sun. PCT Int Appl (2002), WO 200-***-**** A1 .

• “Identification of yacE (coaE) as the structural gene for dephosphocoenzyme A kinase in Escherichia coli K-12.”Pranab K. Mishra, Peter K. Park and Dale G. Drueckhammer*. Journal of Bacteriology, 2001, 183 (9), 2774-2778.

• “Investigating the role of the geminal dimethyl groups in Coenzyme A: synthesis and studies of a di-demethyl analog.” K. W. Vogel, Lucy M. Stark, Pranab K. Mishra, W. Yang and Dale G. Drueckhammer*, Bioorganic and Medicinal Chemistry, 2000, 8, 2451.

• “Coenzyme A analogs and derivatives: synthesis and applications as mechanistic probes of Coenzyme A ester-utilizing enzymes.”Pranab K. Mishra and Dale G. Drueckhammer*, Chemical Reviews, 2000, 100 (9), 2383-3309.

• “Novel cofactor derivatives and cofactor-based models,”Pranab K. Mishra and Dale G. Drueckhammer*, Current Opinion in Chemical Biology, 1998, 2, 758.

• “Synthetic studies toward the preparation of phosphonate analogs of sphingomyelin and ceramide 1-phosphate using pentacovalent organophospholene methodology,” Cynthia K. McClure*, P. K. Mishra, and C. W. Grote, J. Org. Chem. 1997, 63, 2437.

• “Synthetic studies toward the preparation of phosphonate analogs of sphingomyelins and ceramide 1-phosphate using pentacovalent organophosphorus methodology.” Cynthia K. McClure*, Pranab Mishra; Phos., Sulf. and Silicon, 1996, 111, 709.

SELECTED ABSTRACTS

• “Synthesis of densely functionalized pyrrolidinone templates by IMDA directed remote hydroxylation.”Pranab K. Mishra, Sengen Sun, and William V. Murray; Abstract of papers, 222nd ACS National Meeting, Chicago, IL, USA, August 26-30, 2001.

• “Recent advances in Coenzyme A analog synthesis.”Pranab K. Mishra, Dale G. Drueckhammer, Abstract of papers, 220th ACS National Meeting, Washington DC, USA, August 20-24, 2000.

BOOK CHAPTERS

• C. K. McClure*, P. K. Mishra, "Bis(4,5-dimethyl-2-oxo-1,3,2-dioxaphospholenyl) oxide". Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd., 1995, 1, p 503-504.

• Keinan, E., C. K. McClure*, P. K. Mishra, "Diiodosilane", Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd., 1995, 3, p1905-1907.

PRESENTATIONS AND POSTERS

• March 25-29, 2012, San Diego, CA,

Division of Medicinal Chemistry, 243rd National Meeting and Exposition,Arnab Chatterjee, Advait Nagle, Tao Wu, Tomoyo Sakata, Robert Moreau, Jason Roland, Pranab Mishra, David Tully, Valentina Molteni etal. “Cell-based optimization of novel anti-parasitics.”

• March 15-16, 2011, London UK

Anti-Malaria Meeting, Royal College of Surgeons, Arnab Chatterjee, Advait Nagle, Tao Wu, Tomoyo Sakata, Robert Moreau, Jason Roland, Pranab Mishra, David Tully, ValentinaMolteni etal. “Discovery of novel anti-malarials through cell based medicinal chemistry optimization of HTS hits.”

• June 23, Portland, Oregon, 1999

ACS Northwest Regional Meeting, (NORM ’99),C. K. McClure*,P. K. Mishra, "Synthetic Studies toward the preparation of Phosphonate Analogs of Sphingomyelin and Ceramide 1- Phosphate using Pentacovalent Organophosphorus Methodology."

• October 23, Gainesville, Florida, 1996

7th Symposium on the latest trends in Organic Synthesis, C. K. McClure, P.K. Mishra, B.-Z. Cai, R. J. Fisher, J. S. Link, “Recent advances in the use of pentacovalent organophosphoranes in organic synthesis”

• 7-11 July, New Hampton, NH, 1996

Gordon Research Conference on heterocyclic compounds, C. K. McClure, P. K. Mishra (Invited talk) “Synthetic Studies Toward the preparation of Phophonate Analogs of Sphingomyelin and Ceramide 1-Phosphate using Pentacovalent Organophosphorus Methodology,”

• April 2, Anaheim, California, 1995

209th ACS National Meeting, C. K. McClure, P. K. Mishra, “Synthetic Studies Toward the preparation of a Phophonate Analog of Sphingomyelin using Pentacovalent Organophosphorus Methodology."

• July 10, New Hampton, NH, 1994

Gordon Research Conference on Heterocyclic Compounds, C. K. McClure*, K.-Y. Jung, and C. W. Grote, K. B. Hansen, M. P. Sant, P. K. Mishra, K. L. Mayhew, M. W. Embrey, B. A. O'Neil, "Novel Synthetic Routes to Heterocycles via Pentacovalent Phosphorus and Photochemical Methodologies."

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