SAJJAD KHAN

** ******** ***** **,

Calgary, A B T 3J 4W 7

C ell: (587) 894 - 2419

June 30, 2015

E mail : khan.goettingen @gmail.com

Department of Clinical Neuro Sciences

Cumming School of Medicine

Calgary Alberta

Ref: Medical Science Liason / 2725

Dear Sir,

I am writing to express my great interest in the position Medical Science Liason of that listed on your

website. I have a doctorate degree in molecular biology and specializing in cancer research and having

over 7 years of extensive biological research experience, and also proficient in a variety of molecular,

cellular and biochemical techniques. I believe that I would be an asset to your laboratory. I am a

researcher specializing in various lab experience and data collection. This position would provide me

with the ideal opportunity to assist at your organization and to expand my research skills.

I have published in a number of international journals, as my resume will demonstra te in greater detail. I

could increase your competitive advantage with my broad and in-depth knowledge of all the research

components. I feel my skills and qualifications are uniquely suited to the needs of your department.

Skills Offer

Ph.D W ith Cancer Research from the University of Goettingen Germany.

7 years of experience as an independent investigator in the lab, writing proposals for German funding

agencies.

12 publications in a variety of international journals.

I have collaborated with some of the top Gastroenterologists, Hepatalogists, Nephrologists and Brain

cancer biologists in Germany and have also collaborated with researchers from the Boston Medical

School in the US.

Analyzed data, prepared and assisted in manuscript writings for peer reviewed publications. Mentored and

managed junior scientists in the laboratory with projects and taught molecular biological techniques to

medical and biology students in the department of Gastroenterology.

If you would like to discuss further the contributions I could bring to your company, please contact me at

587-***-****. I would be pleased to answer any questions you might have.

Thank you.

Sincerely,

Sajjad Khan

SAJJAD KHAN

Phone # 587-***-****

92 Taradale Dr.NE Calgary, AB

acqi3f@r.postjobfree.com

SUMMARY OF QUALIFICATIONS:

Over 7 years of extensive biological research experience, proficient in a variety of

molecular, cellular and biochemical techniques

Experienced in advanced molecular biology techniques including DNA & RNA

extraction, protein isolation, sequencing, molecular cloning electrophoresis and

western blotting, Immuno-histochemistry, light microscopy and spectroscopy,

microarray-analysis optimization and handling of Real Time polymerase chain

reaction (PCR).

Experienced in using molecular biology research tools, MS office, Graph -pad, Image-J,

Reference Manager

Well-developed problem solving, communication, interpersonal and organizational skills,

gained by working with a diversity of professionals, clients, and staff members

Fluent in English, German, Urdu, Hindi, Pashto

EDUCATION & CAREER DEVELOPMENT:

Corporate Readiness Training Program (CRTP) Oct 2014-Dec 2014

Bow Valley College Calgary, Alberta Canada

Doctorate (PhD-Biology) IQAS Certified 2013

Georg-August University Göttingen Germany

Doctoral thesis Project: Differential gene expression of Chemokines in KRAS and

BRAF mutated colorectal cell lines: Role of cytokines

M.Sc (Biology) IQAS Certified 2006

Georg-August University Göttingen Germany

PROFESSIONAL EXPERIENCE

Researcher 2013-2014

University Medical Centre Georg-August University, Göttingen Germany.

Investigated colorectal carcinoma cell lines in vitro for the KRAS and BRAF mutations by

creating different micro-environment with the treatment of cytokines

Established animal models (mice and rats) exposed to different radiation by

injecting d ifferent cytokines recombinant at different time intervals

Dissected animals (rats and mice), examined and photographed specimens,

collected liver and colon for chemical analysis and recorded findings

Analyzed RNA and protein d ata from mice models for different acute phase

cytokines and growth factors.

Analyzed data, prepared and assisted in manuscript writings for peer reviewed

publications

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Sajjad Khan acqi3f@r.postjobfree.com Cell. +1-587-***-****

Mentored and managed junior scientists in the laboratory with their projects and taught

molecular biological techniques to the medical and biology students in the

department of Gastroenterology

Researcher 2009- 2013

University Medical Centre Georg-August University, Göttingen Germany.

Treated different human colorectal carcinoma cell lines with different acute

phase cytokines (TNFα, IL-1ß, IL-6 and IFNγ) for possible mutational based t herapy

Analysed human cell lines on RNA and protein basis in view of different mutations

Developed knock out animal models in exposure to different radiation levels

to compare with the human data

Analysed the colo-cell lines on the basis of KRAS and BRAF mutations

Involved in t ranslational research for human cancer by interpreting the data

obtained from in-vivo (animals and patients) and in-vitro sources

Assisted Master s tudents in their final year degree projects a long with their report

write-ups and research

Research Assistant 2005-2008

Institute of Molecular Phytopathology Georg-August University, Göttingen Germany.

Planned and conducted studies of the environment structure and functional

characteristics and behaviour of plants and insects

Conducted research to discover, develop and refine and evaluate new products

Developed and implemented disease and pest control p rograms such as

I ntegrated Pest Management (IPM)

Assessed role of herbivoral insects effect by inoculating fungi to the weedy

plants under field conditions

Conducted studies into the identification and effects of animal and plant

pathogens

Assisted and collected data for analysis and prepared reports for journals

Presented significant findings in workshops, conferences and for funding

agencies

ACHEIVEMENTS:

Published twelve[12] International Publications

Five [5] Abstracts and Poster Presentations in International Conferences with a

winning Poster prize: German Association for the study of the Liver (GASL),

American Society of Clinical Oncology (ASCO), Academic Drug Development in

Oncology (Berlin), European Association for the study of Liver (EASL)

VOLUNTEER WORK:

Office Administrative Volunteer May 2014-Present

Canadian Cancer Society, Alberta/North West Territories Calgary Canada

Maintains and updates donors filing, inventory, mailing and data base either manually or

using the computer software

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Sajjad Khan acqi3f@r.postjobfree.com Cell. +1-587-***-****

DISTINCTION & AWARDS

Published twelve[12] International Publications

Five [5] Abstracts and Poster Presentations in International Conferences with a

winning Poster prize: German Association for the study of the Liver (GASL), American

Society of Clinical Oncology (ASCO), Academic Drug Development in Oncology

(Berlin), European Association for the study of Liver (EASL)

Ph.D Scholarship from Göttingen University Germany

Talent Scientific Scholarship Government of Pakistan

Research and Academic Experience (International Publications)

1. Khan S, Cameron S, Blaschke M, Naz N, Moriconi F, Amanzada A,

Ramadori G, Malik IA (2013). Differential gene expression of c hemokines

in KRAS and BRAF mutated colorectal cell lines: Role of cytokines. World J

Gastroenterol 2014 March 21; 20(11):2979-94

2. Amanzada A, Malik IA, Blaschke M, Khan S, Rahman H, Ramadori G (2013)

Identification of CD68+ neutrophil granulocytes in-vitro model of acute

inflammation and inflammatory bowel disease. International Journal of Clinical

and Experimental Pathology.

3. Naz N, Moriconi F, Ahmad S, Amanzada A, Khan S, Mihm S, Ramadori G,

Malik IA (2013) Ferritin L is The Sole Serum Ferritin Constituent and a Positive

Hepatic Acute Phase Protein. Shock; 39(6):520-6.

4. Moriconi F, Ramadori P, Schultze FC, Blaschke M, Amanzada A, Khan

S, Ramadori G (2013) Characterization of the

erythropoietin/erythropoietin receptor axis in a rat model of liver

damage and cholangiocarcinoma development. Histochem Cell Biol

139:473-485

5. Naz N, Moriconi F, A hmed S, Amanzada A, Khan S, Mihm S, Ramadori G,

Malik IA (2013) Ferritin L is The Sole Serum Ferritin Constituent and a Positive

Hepatic Acute Phase Protein. Shock

6. Malik IA, Triebel J, Posselt J, Khan S, Ramadori P, Raddatz D, Ramadori G

(2012) Melanocortin receptors in rat liver cells: change of gene

expression and intracellular localization during acute-phase

response. Histochem Cell Biol 137:279-291

7. Moriconi F, Malik IA, Amanzada A, Blaschke M, Raddatz D, Khan S,

Ramadori G (2012) The anti-TNF-alpha antibody infliximab in directly

regulates PECAM-1 gene expression in two models of in vitro blood cell

activation. Lab Invest 92:166-177

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Sajjad Khan acqi3f@r.postjobfree.com Cell. +1-587-***-****

8. Naz N, Malik IA, Sheikh N, Ahmad S, Khan S, Blaschke M, Schultze F,

Ramadori G (2012) Ferroportin-1 is a 'nuclear'-negative acute-phase

protein in rat liver: a comparison with other iron-transport proteins. Lab

Invest 92:842-856

9. Wojcik M, Ramadori P, Blaschke M, Sultan S, Khan S, Malik IA, Naz

N, MartiusG, Ramadori G, Schultze FC (2012) Immunodetection of

cyclooxygenase -2 (COX-2) is restricted to tissue macrophages in

normal rat liver and to recruited mononuclear phagocytes in liver injury

and cholangiocarcinoma. Histochem CellBiol 137:217-233

10. Malik IA, Naz N, Sheikh N, Khan S, Moriconi F, Blaschke M,

Ramadori G (2011) Comparison of changes in gene expression of

transferrin receptor -1 and other iron- regulatory proteins in rat liver

and brain during acute -phase response. Cell T i s s u e Res 344:299-312

11. Malik I A, Moriconi F, Sheikh N, Naz N, Khan S, Dudas J, Mansuroglu T, Hess CF,

Rave- Frank M,Christiansen H,Ramadori G (2011). Single-dose gamma

irradiation induces up- regulation of chemokine gene expression and

recruitment of granulocytes into the portal area but not into other regions of rat

hepatic tissue Am J Pathol 1 76:1801 -1815

International Conferences Abstracts Published

1. Khan S, Malik I A, Blaschke M, Naz N, Cameron S, Moriconi F, Ramadori

G (2011).Differential gene expression of chemokines in KRAS and BRAF

mutated colorectal cell lines: Role of cytokines

Academic Drug Development in O ncology -Translating B asic S c i e n c e

Research i n t o Innovative Treatments. November 2011 in Berlin

2. Khan S, Malik I A, Blaschke M, Naz N, Cameron S, Moriconi F, Ramadori

G (2011).Differential gene expression of chemokines in KRAS and BRAF

mutated colorectal cell lines: Role of cytokines

Falk Workshop“Inflammation and Cancer”January 2012 Hamburg

3. Malik IA, Triebel J, Posselt J, Ramadori P, Raddatz D, Khan S and

Ramadori G. “Melanocortin receptors in rat liver cells:change of gene

expression and localization during acute-phase-response”.

German Association for t h e s t u d y of the liver 27th Annual Meeting 2011 (GASL 2011)

Regensburg, Germany.

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Sajjad Khan acqi3f@r.postjobfree.com Cell. +1-587-***-****

4. Malik I A, Moriconi F, Sheikh N, Naz N, Khan S, Dudas J, Mansuroglu T, Hess CF, Rave-

Frank M,Christiansen H,Ramadori G (2011). Single-dose gamma irradiation induces

up-regulation of chemokine gene expression and recruitment of granulocytes into the

portal area but not into other regions of rat hepatic tissue.

American Society of Clinical Oncology (ASCO, 2010) Chicago, USA.

References: Available upon request

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Sajjad Khan acqi3f@r.postjobfree.com Cell. +1-587-***-****

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