HASSANA FATHALLAH, PhD

CURRICULUM VITA

EDUCATION

• Clinical laboratory training in oncology – molecular and cellular tumor markers, Mount Sinai Medical Center, New York, NY, 2008

• Postdoctoral training in Gene Therapy, Mount Sinai School of Medicine, New York, NY, 1998-2003

• PhD in Biochemistry, University of Paris XI, France, 1997

• MS in Biology & Biochemistry, University of Paris XI, France, 1993

• BS in Biochemistry & Molecular Biology, University of Paris XI, France, 1990

CERTIFICATES

• Certificate of qualification: Clinical Laboratory Director In Oncology-Molecular and Cellular Markers New York State Department of Health, 2009-present

APPOINTMENTS

• Director, Laboratory Technical and Scientific Affairs, Pharmaceutical Product Development (PPD), Highland Heights, KY, July 2014-April 2015

Responsibilities: Direct the activities and operations of the Lab Technical and Scientific Affairs Department to support the global central laboratory (US, EU, Singapore and Shanghai) that maintains a number of industry accreditations and certifications like CAP, CLIA, NYSDOH and NGSP

Major Accomplishments: Established, organized and structured a new department in charge of assay and instrument validations, metrology and quality control programs, scientific and technical review of all sponsor projects, liaison between global central laboratory and sponsors, coordinating activities across an extensive, international network of external third-party laboratories and ensuring adherence to GLP standards, FDA, CLIA and CAP regulations and clinical laboratory standards institute (CLSI) guidelines

• Scientific Director of the Tumor Bank: Cancer Institute, University of Cincinnati, Cincinnati, OH, July 2009-July 2014

Responsibilities: Direct, manage, supervise and coordinate the activities and operations of the Cancer Institute Tumor Bank

Major Accomplishments: Established centralized tumor bank following National Cancer Institute best practices guidelines for biorepositories. Developed and maintained IRB approved protocols for collection of specimen associated with clinical and pathology data. Organized and structured facility operations. Created and maintained the database. Developed and implemented Standard Operating Procedures Manual to provide support and guidance to staff. Implemented a quality control program. Organized a scientific review committee in charged with the task of reviewing and critically assessing sample requests for scientific merit and quality and prioritizing these to ensure optimal use of the samples. (http://cancer.uc.edu/Research/CoreFacilities/TumorBanking.aspx) (http://www.bizjournals.com/cincinnati/print-edition/2011/05/06/tumor-banking-picks-up-speed-at-uc.html)

• Director of the Translational Research Core: Division of Hematology/Oncology, University of Cincinnati, Cincinnati, OH, March 2010- July 2014

Responsibilities: Direct and manage the core operations.

Major Accomplishments: Developed biochemical, molecular, and cellular assays. Facilitated interactions between investigators and clinicians by collaborating and data sharing. Developed laboratory manuals and regulatory policies. Assisted, participated and generated data for pre-clinical and clinical oncology projects related to disease-based biomarkers and pharmacodynamics.

• Research Assistant Professor: Division of Hematology/Oncology, University of Cincinnati, Cincinnati, OH, July 2009- July 2014

Responsibilities: Develop and manage major research projects with some teaching and service requirements

Major Accomplishments: Designed and developed different research projects and made sure that all projects are well-planned and are using appropriate experimental designs suitable to study endpoints. Gave multiple educational lectures to graduate students and medical fellows. Served on multiple committees as member and/or organizer. Participated to multiple national and international scientific meetings as speaker and/or organizer. Assisted with peer-review process for different scientific journals.

• Assistant Professor: Division of Hematology/Oncology, Mount Sinai School of Medicine, New York, NY, July 2005-June2009

• Instructor: Division of Hematology/Oncology, Mount Sinai School of Medicine, New York, NY, July 2003- June 2004

TEACHING

• Lecturer, Grand Rounds, Division of Hematology and Oncology, University of Cincinnati, 2014

• Lecturer, Methods in Biomedical Research course (PhD students), University of Cincinnati, 2011-2013

• Lecturer, Fellows core curriculum lecture series, Division of Hematology and Oncology, University of Cincinnati, 2011-2013

• Facilitator, Medical Pharmacology Small Groups Session, Cincinnati, OH, 2012

• Judge, Internal Medicine Trainees’ Research Grand Rounds (1st and 2nd year medical students), University of Cincinnati, 2013

• Judge, the Residents and Students Medical Grand Rounds, University of Cincinnati, 2012

• Judge, Internal Medicine Trainees’ Research Grand Rounds, University of Cincinnati, 2012

• Lecturer, The Immortal Life of Henrietta Lacks Program, Colleges of Arts & Sciences, University of Cincinnati, 2012

• Lecturer, Internal Medicine Staff Meeting, University of Cincinnati, 2010

COMMITTEE INVOLVEMENT

• Member, Gastrointestinal Cancer Center Of Excellence Committee, University of Cincinnati, Cincinnati, OH, 2013

• Member, Breast Center Of Excellence Basic Science Research Committee, University of Cincinnati, Cincinnati, OH, 2013

• Organizer and Member, Cancer Institute Tumor Bank Scientific Review Committee, University of Cincinnati, Cincinnati, OH, 2012-2014

• Member, Cancer Institute Protocol Review and Monitoring Committee, University of Cincinnati, Cincinnati, OH, 2011-2014

• Member, Red Cell Conference Planning Committee. Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2010

PROFESSIONAL ACTIVITIES

• Basic Method Validation course, American Association for Clinical Chemistry (AACC), 2015

• American Society of Hematology Annual Meeting, New Orleans, LA Dec 6-10, 2013

• Cancer Informatics for Cancer Centers Symposium, Napa Valley, CA, Nov 20-22, 2013

• Human Subject Protection Conference, Covington, KY, SEP 20th 2013

• Empirical Bioethics: Emerging Trends for the 21st Century, Cincinnati, OH Feb 21-22, 2013

• Pfizer Investigator Training Program Cincinnati, Ohio Oct 9th & 10th 2012

• Biospecimen Research Network Annual Symposium North Bethesda, MD, Feb 22-23, 2012

• Cardiopulmonary Complications of Sickle Cell Disease Symposium Cincinnati, OH May 18, 2011

• Biospecimen Research Network Annual Symposium North Bethesda, MD, Mar 28-29, 2011

• Center for Clinical and Translational Science and Training forum Biobanking Cincinnati, OH Jan 27, 2011

• American Society of Hematology Annual Meeting Orlando, Florida Dec 4-7, 2010

• American Society of Hematology Annual Meeting New Orleans, LA Dec 5-8, 2009

NATIONAL/INTERNATIONAL DISTINGUISHED ACTIVITIES

• Speaker, Cancer Informatics for Cancer Centers Symposium Napa Valley, CA, 2013

• Meet-the-Experts leader, Biospecimen Research Network Annual Symposium Bethesda, MD, 2012

• Speaker, GU Research Symposium University of Cincinnati, Cincinnati, OH, 2011

• Speaker, Cancer Study Seminar; University of Cincinnati, Cincinnati, OH, 2011

• Organizer and Speaker, Annual Red Cell Club Meeting; Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2010

• Speaker, HPV Mini-symposium; Cincinnati Children Hospital Medical Center, Cincinnati, OH, 2010

• Speaker, Annual American Society of Hematology Meeting, Orlando, Florida, 2006

• Speaker, Division of Hematology & Oncology Research Conference, Mount Sinai School of Medicine, New York, NY, 2006

• Speaker, Annual Sickle Cell Disease Clinical Meetings, Bethesda, MD, 2005

• Speaker, Annual Sickle Cell Disease Clinical Meetings, Bethesda, MD, 2004

• Speaker, Department of Medicine Research Conference, Mount Sinai School of Medicine, New York,, NY, 2004

• Speaker, Annual Sickle Cell Disease Clinical Meetings, Bethesda, MD, 2003

• Speaker, Division of Hematology & Oncology Research Conference, Mount Sinai School of Medicine, New York,, NY, 2003

GRANTS & CONTRACTS

• A Dose Escalation, Single Arm, Phase 1b-2 Combination Study of BEZ235 with Everolimus to Determine the Safety, Pharmacodynamics and Pharmacokinetics in Subjects with Advanced Solid Malignancies. Sponsor: University of Cincinnati and Novartis Pharmaceuticals. H. Fathallah (co-PI) 2012 -2014

• Reversal of Epigenetic Silencing of the Gamma-Globin Genes. Sponsor: NIH, R01 HL073438 (NIH/NHLBI). H. Fathallah (co-PI); 2003- 2007

• Panhematin Effects on Fetal Globin Activation in Hemoglobin Disorders. Sponsor: Ovation Pharmaceuticals. H. Fathallah (co-PI); 2006- 2007

PEER REVIEWING

• Plos One

• Gene

• Journal of Translational Medicine

• European Journal of Hematology

• Haematologica

• Acta Haematologica

SKILLS

• Expertise in molecular biology, cell culture, epigenetics

• Strong analytic curiosity/ creativity

• Expert in clinical and research data management in compliance with federal, state and institutional regulations, guidance and policies to ensures security of research data and personal health information

• Strong skills in critical thinking and Strong planning and organizational skills

• Expert in multiple laboratory techniques and Design, develop, qualify, and transfer analytical assays

• Focus on team building, motivation and collaboration

• Excellent interpersonal, oral and written communication skills

• High-performing and energetic personality with proactive approach and “can-do” attitude

• Continuously learning and improving and adapt to new responsibilities

• Ability to drive cross functional teams to consensus and on-time completion

• Perform data analysis, write internal reports, document studies and develop all relevant documentation associated with operations

• Distill complex issues and clearly present solutions

• Computer skills: EP Evaluator, LMS, Microsoft office (Word, Excel, PowerPoint, Outlook, Visio, Project, OneNote and Publisher), Adobe Acrobat professional, EndNote, Geneious, Tableau, Beacon Designer, Biomaterial Tracking & Management Research System

• Trilingual: English, French and Arabic

PUBLICATIONS

Peer Reviewed Articles:

• Nagla Abdel Karim, Sandra L. Starnes, John C. Morris, Ashley Perry, Peter Pathrose, Hassana Fathallah. KRAS molecular profiling in non-squamous non-small cell lung cancer. in preparation

• Mohamad Adham Salkeni, Olivier Rixe, Nagla Abdel Karim, Sue Ogara, Monica Feiler, Ganesh Moorthy, Carol A Mercer, Hala Thomas, Pankaj B Desai, Hassana Fathallah, Sara Kozma, George Thomas, John Charles Morris. BEZ235 in combination with everolimus for advanced solid malignancies: Preliminary results of a phase Ib dose-escalation study. in preparation

• Fathallah H, Ali Taher, Ali Bazarbachi and Atweh GF. Differences in Response to Fetal Hemoglobin Induction Therapy in Beta-Thalassemia and Sickle Cell Disease Blood Cells Mol Dis. 2009

• Fathallah H, Portnoy G and Atweh GF. Epigenetic Analysis of the Human Alpha- and Beta-Globin Gene Clusters Blood Cells Mol Dis. 2008 Mar-Apr;40(2):166-73

• Fathallah H, Weinberg RS, Galperin Y, Sutton M and Atweh GF. Role of Epigenetic Modifications in Normal Globin Gene Regulation and Butyrate-Mediated Induction of Fetal Hemoglobin Blood. 2007 Nov 1;110(9):3391-7

• Sauvage M, Maziere P, Fathallah H, Giraud F. Insulin Stimulates NHE1 Activity by Sequential Activation of Phosphatidylinositol 3-Kinase and Protein Kinase C Zeta in Human Erythrocytes Eur J Biochem. 2000; 267: 955-962

• Joiner CH, Jiang M, Fathallah H, Giraud F, Franco RS. Deoxygenation of Sickle Red Blood Cells Stimulates KCl Cotransport without Affecting Na/H Exchange Am J Physiol. 1998; 74:C1466-C1475

• Fathallah H, Sauvage M, Romero JR, Canessa M, Giraud F. Effects of PKC Alpha Activation on Ca2+ Pump and K (Ca) Channel in Deoxygenated Sickle Cells Am J Physiol. 1997; 273: C1206-C1214

• Fathallah H, Coezy E, De Neef RS, Hardy-Dessources MD, Giraud F. Inhibition of Deoxygenation-Induced Membrane Protein Dephosphorylation and Cell Dehydration by Phorbol Esters and Okadaic Acid in Sickle Cells Blood. 1995; 86: 1999-2007

• Georges Roussi, Jacqueline Chastanet, Hassana Fathallah, Guillermo Negron. [3+2] Cycloaddition of Chiral Azomethine Ylides from Aminosugar N-Oxides. Enantioselective Synthesis of 3,4-Disubstituted Pyrrolidines., Heterocycles 1992; 34(8): 1565-1572

Books, Chapters, Reviews, and Invited Papers:

• Atweh GF and Fathallah H. Pharmacological Induction of Fetal Hemoglobin Production. Hematol Oncol Clin North Am,

• Fathallah H. DNA Hypomethylation Therapies and Hemoglobin Disorders. Clinical Advances in Hematology & Oncology. 2008 November; 6(11):806-808

• Fathallah H and Atweh GF. Induction of Fetal Hemoglobin in the Treatment of Sickle Cell Disease Hematology (Am Soc Hematol Educ Program). 2006;:58-62;

• Fathallah H and Atweh GF. DNA Hypomethylation Therapy for Hemoglobin Disorders: Molecular Mechanisms and Clinical Applications. Blood Rev., 2006; 20: 227-234;

• Fathallah H, Sutton M, Atweh GF. Pharmacological Induction of Fetal Hemoglobin: Why Haven’t We Been More Successful in Thalassemia? Ann. N.Y. Acad. Sci. 2005; 1054: 228-237 cited 14

• Atweh GF, DeSimone J, Saunthararajah Y, Fathallah H, Weinberg RS, Nagel RL, Fabry ME, Adams RJ. Hemoglobinopathies Hematology (Am Soc Hematol Educ Program). 2003:14-39

Abstracts:

• Nagla Abdel Karim, Sandra L. Starnes, John C. Morris, Ashley Perry, Peter Pathrose, Hassana Fathallah. KRAS molecular profiling in non-squamous non-small cell lung cancer. AACR-IASLC Joint Conference on the Molecular Origins of Lung Cancer, January 2014

• Mohamad Adham Salkeni, Olivier Rixe, Nagla Abdel Karim, Sue Ogara, Monica Feiler, Ganesh Moorthy, Carol A Mercer, Hala Thomas, Pankaj B Desai, Hassana Fathallah, Sara Kozma, George Thomas, John Charles Morris. BEZ235 in combination with everolimus for advanced solid malignancies: Preliminary results of a phase Ib dose-escalation study. J Clin Oncol 31, 2013 (suppl; abstr e13518)

• Charmaine A. Ramlogan-Steel, Jason C. Steel., Hassana Fathallah, Camelia Iancu-Rubin, Manoocher Soleimani, Zhongyun Dong and George F. Atweh. The Role of Stathmin, a Regulator of Mitosis, in Hematopoiesis. Poster presentation at 2012 Annual American Society of Hematology Meeting. https://ash.confex.com/ash/2012/webprogram/Paper51779.html

• Mohamad Adham Salkeni, Muhammad Shaalan Beg, Olugbenga Olanrele Olowokure, Hassana Fathallah, Hala Thomas, Carol A Mercer, Mahmoud Charif, Rekha T. Chaudhary, Nagla Abdel Karim, Ronald Warnick, Christopher McPherson, Ganesh Moorthy, Pankaj B Desai, Sara Kozma, George Thomas, Olivier Rixe. A dose escalation, single arm, phase Ib/II combination study of BEZ235 with everolimus to determine the safety, pharmacodynamics, and pharmacokinetics in subjects with advanced solid malignancies including glioblastoma multiforme. Poster presentation at 2012 ASCO Annual Meeting J Clin Oncol 30, 2012

• Wicker CA, Winstead K, Sagin S, Fathallah H. Improving Biospecimen Collection Practices at the UC Cancer Institute Tumor Bank. Poster presentation at 2012 Biospecimen Research Network Symposium. http://biospecimens.cancer.gov/meeting/brnsymposium/2012/posters.asp

• Sagin S, Winstead K, Wicker CA, Fathallah H. Standardization of Consent Practices at the UC Cancer Institute Tumor Bank: Challenge In Biobanking. Poster presentation at 2012 Biospecimen Research Network Symposium. http://biospecimens.cancer.gov/meeting/brnsymposium/2012/posters.asp

• Fathallah H, Taher A, Bazarbachi A and Atweh GF. Differences in Fetal Hemoglobin Induction in Sickle Cell Disease and Beta-Thalassemia. Oral presentation at the Annual American Society of Hematology Meeting, Orlando, Florida. Blood, 2006; 108 (11): 167A-167A 555

• Fathallah H, Taher A, Bazarbachi A and Atweh GF. Additive effect of Butyrate and Hemin on Fetal Hemoglobin induction in erythroid cells from Sickle Cell Disease and Beta-Thalassemia. Poster presentation at the Annual American Society of Hematology Meeting, Orlando, Florida. Blood, 2006; 108 (11): 360A-360A 1224

• Fathallah H, Galperin Y, Weinberg RS and Atweh GF. Effects of induction of fetal hemoglobin with butyrate on histone acetylation in the human γ-globin gene locus. Poster presentation at the Annual American Society of Hematology Meeting, Orlando, Florida. Blood, 2003; 102:262a

• Fathallah H and Atweh GF. Characterization of histone acetylation and butyrate effects in the human fetal erythroid environment of K562 cells. Poster presentation at the Annual American Society of Hematology Meeting, Orlando, Florida. Blood, 2003; 102:517a

• Merciris P, Hardy-Dessources MD, Fathallah H, Giraud F. Modulation of sickle cell dehydration by protein tyrosine kinase activity. Hematologie. 1997; 3: 18

• Fathallah H, Coezy E, De Neef RS, Hardy-Dessources MD, Giraud F. Membrane protein phosphorylation and sickle cell dehydration. Sickle cell disease and thalassaemia. Poster presentation at the New trends in Therapy for Hemoglobinopathies and Thalassemias, Paris New trends in therapy. Eds. Y. Beuzard, B. Lubin, J. Rosa, Colloque INSERM/John Libbey Eurotext Ldt. 1995; 234: 561

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