CURRICULUM VITAE

WILLIAM J. CIRKSENA, M.D., F.A.C.P.

Identifying Information:

Place of birth: Hastings, Nebraska, USA, March 30, 1934

Marital Status: Married, Molly E. Cirksena

Home address: 813 Coachway, Annapolis, MD 21401

Telephone: 410-***-**** (home); 443-***-**** (cell)

Email: acq0a5@r.postjobfree.com

SSA ODAR Medical Expert: DUNS No.: 078313754; Award No.: 103****-*****

Education:

Medical School: 9/55-6/59 University of Nebraska College of Medicine, Omaha, NE. M. D., cum laude, 1959, Sidney R. Kent Valedictory award.

College: 9/52-6/55 Hastings College. Hastings, NE; B. A.(Biology), summa cum laude, 1956

Medical Training:

Fellowship: 7/63-6/65 Nephrology, Laboratory of Kidney and Electrolyte Metabolism, National Heart Institute, National Institutes of Health, Bethesda, MD.

Residency: 7/60-6/63 Internal Medicine, Walter Reed General Hospital Medical Service, Washington, DC

Internship: 7/59-6/60 Medical Service Rotating Internship, Letterman General Hospital, San Francisco, CA

Military Experience:

Consultant in Renal Diseases to the US Army Surgeon General 7/69-6/71

Chief, Dept. of Metabolism, Walter Reed General Hospital, Washington, DC 7/69-6/71

Chief, Experimental Nephrology Section, Walter Reed General Hospital 7/67-6/71

Staff, Internal Medicine, Walter Reed General Hospital 6/65-6/69

Research Internist, Walter Reed Army Institute of Research, Washington, DC 6/65-6/67

US Army Medical Corps, RA number 091189; resigned commission as LTC 6/30/71

Medical Service Corps, US Army Reserve, Jr/Sr Medical Student Program. Service no. 02295407. 7/57-6/59

Civil Service:

Medical Officer (40/80) DC General Hospital, Washington, DC, Georgetown University Medical School Nephrology service 7/77-6/82.

Medical Practice:

7/70-7/12 Founder Metropolitan Washington Renal Dialysis Centers, developing a large number of dialysis centers in Maryland, Virginia, the District of Columbia, and Arizona with National Medical Care/Fresenius Medical Care; served as medical director of multiple dialysis facilities in these areas.

7/86-4/00 Founder and permanent member of the Management Committee of Washington Nephrology Associates, a multi-specialty medical practice of 28 physicians including nephrologists, vascular and transplant surgeons, and gastroenterologists, and one of the largest nephrology practice groups in the United States. Practiced nephrology in Maryland, the District of Columbia, and northern Virginia from 1970 until retirement from active practice 4/1/00.

Staff Appointments:

7/77-6/02 Anne Arundel Medical Center, Annapolis, MD, active staff in internal medicine and nephrology; emeritus status 2002.

7/75-6/86 Washington Hospital Center, Washington, DC, Senior Attending Physician

7/75-6/82 District of Columbia General Hospital, staff nephrologist

7/73-6/75 Chief, Arlington-Georgetown Nephrology Service, Arlington Hospital, Arlington, VA

7/71-6/83 Clinical Associate Professor of Medicine, Georgetown University School of Medicine, Washington, DC

6/68-9/74 Suburban Hospital, Bethesda, MD, active staff, internal medicine

Professional Organizations:

Alpha Omega Alpha, University of Nebraska, 1958

American Medical Association

American College of Physicians

American Society of Nephrology

American Federation for Clinical Research

American Phsysiological Society

American Society of Artificial Internal Organs

International Society of Nephrology

Medical and Chirurgical Faculty of Maryland

Medical Licenses:

Maryland: License No. D0001228 Expires 9/30/16

DEA No. AC2445927 Expires 8/31/18

CDS Reg. No. M22770 Expires 10/31/15

Hawaii: License No. MD-114513 Expires 1/31/16

DEA No. BC9921621 Expires 8/31/18

NED No. E05599 Expires 8/31/18

Board Certification:

American Board of Internal Medcine, 4/18/68

Board-eligible Nephrology; certified Nephrologist by Maryland Board of Physician Quality Assurance, 3/30/91

Fellow, American College of Physicians (FACP) 11/9/68

Business Experience:

Founder, with Molly E. Cirksena and Jeffrey L. Tredwell, DPM, of Diabetic Foot Centers of America. The DFC proprietary technology was subsequently incorporated into Diabetex, Inc., a company dedicated to the general and foot health of patients with diabetes. Diabetex subsequently evolved into XLHealth Corporation, which provided disease management of diabetes and other chronic medical conditions, and medical insurance to Medicare recipients. As a founder and member of the Board of Directors from inception through 2008, was instrumental in the evolution of an initial local enterprise into a multi-state disease management and medical insurance company which was aquired by United Healthcare February 2012.

Founder, with Molly E. Cirksena and William F. Niland, of Vapotherm Inc., the developer and innovator in the provision of high-flow respiratory therapy devices for in-hospital patients, infants in the neo-natal intensive care unit, and outpatients with chronic respiratory illnesses and sleep apnea. As a founder and member of the Board of Directors through 2008, was instrumental in the translation of a patented high-flow theory into a marketable device which is now sold and provides state-of-the-art respiratory care in hospitals throught the United States, Europe, and elsewhere.

BIBLOGRAPHY

1. Frank, W. J., Brennan, J. T. Newcomer, K. L, and Cirksena, W. J. – Observations on the concomitant us of X-rays and 5-fluroruracil in human malignant neoplasms. Med. Ann. of D. C., 1962, 31, 12-18.

2.Deller, J. J., Cirksena, W. J., and Marcarelli, J. L. – Fatal pancytopenia associated with viral hepatitis. NEJM, 1962, 266, 297-299.

3.Cirksena, W. J., Deller, J. J., and Marcarelli, J. L. – Adult Chronic Lead Intoxication. AMA Arch. Env. Health,, 1962, 4, 183-190.

4. Cirksena, W. J. -Tetanus. Am. J. Nur. 1962, 65-69.

5. Frank, W. J., Newcomer, K. L., Cirksena, W. J., Bauer, A. J., and Blom, J.

Further observations on the concomitant use of x-rays and 5-furouracil on neoplasms of humans. Can. Chem. Rep. 1962, 22, 55-58.

6. Frank, W. J., Newcomer, K. L., and Cirksena, W. J. - Observations on the concomitant use of x-rays and 5-fluorouracil in human malignant neoplasms, Chemotherapia. (Abstract) presented to II International Congress of Chemotherapy, Naples, Italy, 1962.

7. Batt, R. E., Cirksena, W. J., and Lebberz, T. B. - Gout and salt-wasting renal disease during pregnancy. JAMA, 1963, 186, 835-838.

8. Cirksena, W . J., Bastian, R. C., Malloy, J. P., and Barry, K. G. - Use of mannitol in exogenous and endogenous intoxications. NEJM, 1964, 270, 161-166.

9. Shambaugh, G. E., Cirksena, W. J., and Newcomer, K. L. - Carpal tunnel syndrome and sarcoidosis. AMA Arch. Int. Med., 1964, 114, 830-833.

10. Dirks, J. H., Cirksena, W. J., and Berliner, R. W. - Effect of saline infusion on sodium reabsorption by the proximal tubule of the dog. Fed. Proc. 1965. (Abstract)

11. Cirksena, W. J., Dirks, J. H., and Berliner, R. W. - Effect of caval ligation. J. Clin. Invest. 1965, 44, 1035 (abstract) presented at 57th Annual Meeting of the Amer. Soc, for Clin. Invest., Atlantic City, NJ, 1965.

12. Dirks, J. H., Cirksena, W. J., and Berliner, R. W., The effect of saline infusion on sodium reabsorption by the proximal tubule of the dog. J. Clin. Invest. 1965. 44, 1160-1170.

13. Cirksena, W. J., Dirks, J. H., and Berliner, R. W. - Effect of thoracic cava obstruction on response to proximal tubule sodium reabsorption to saline infusion. J. Clin. Invest., 1966, 45, 179-186.

14. Berliner, R. W., Dirks, J. H., and Cirksena, W. J. - Action of diuretics in dogs studied by micropuncture. Annals of N.Y. Acad. Sci., 1966, 139, 424-432.

15. Berliner, R. W., Dirks, J. H., and Cirksena, W. J. - Action of diuretics in dogs studied by micropuncture. (abstract) presented to Conference on the Physiology of Diuretic Agents, New York Academy of Sciences, New York, NY, 1966.

16. Dirks, J. H., Cirksena, W. J., and Berliner, R. W. - Micropuncture study of the effect of various diuretics on sodium reabsorption by the proximal tubules of the dog. J. Clin. Invest., 1966, 45, 1875-1885.

17. McNichol, R. W., Cirksena, W. J., Payne, J. T., and Glasgow, M. C. - Management of withdrawal from alcohol (including delerium tremens) South M. J., 1967, 60, 7-12.

18. Cirksena, W. J., Teschan, P. E. - Micropuncture study of intratubule pressure in a model of pigment nephropathy in the rat. Pro. Am. Soc. Of Nephrol. 1967, 1, 12. (Abstract) presented at the 1st Annual Meeting of the American Society of Nephrology, Los Angeles, CA, 1967.

19. Fein, R. L., Schrier, R. W., and Cirksena, W. J. - Renal response to acute extracellular fluid volume (ECF) expansion after decapsulation of the kidney. Proc. Am. Soc. Of Nephrol., 1967, 1, 18. (Abstract).

20 Cirksena, W. J., and Teschan, P. E. - Pathophysiology of acute renal failure. Presented at annual meeting of Southern Salt, Water, and Kidney Club, Sarasota, FL, 1967. (Abstract).

21 Cirksena, W. J., McNeil, J. S., Fein, R. L., and Schrier, R. W. - Influence of interstitial fluid volume (ISF) expansion and plasma sodium concentration (PNa) on the natruiuretic response to saline infusion. Clin. Res., 1967, 16, 380. (Abstract)

22. Gilliland, P. F., Brooks, M. H., Cirksena, W. J., Malloy, J. P., Bruton, J., and Barry, K. G. - Pituitary-adrenal function in acute falciparum malaria. Clin. Res. 1968, 16, 330. (Abstract)

23. Donadio, J. V., Whelton, A., Gilliand, P. F., and Cirksena, W. J., Peritoneal dialysis in quinine intoxication, JAMA (letter to the editor) 1968, 204, 182.

24. Fein, R. L., Schrier, R. W., and Cirksena, W. J. - Responses to acute extracellular fluid volume expansion after acute and chronic decapsulation of the kidney. Proc. Soc.Exp. Biol. and Med. 1968, 128, 602-607.

25. Brooks, M. H., Barry, K. G., Cirksena, W. J., Malloy, J. P., Bruton, J., and Gilliland, P. F. - Pathophysiology of acute falciparum malaria: pituitary-adrenal function. Accepted for publication in Am. J. Trop. Med.

26. Schrier, R. W., Fein, R. L., McNeil, J., and Cirksena, W. J. - influence of interstitial fluid volume expansion and plasma osmolality on the natriuretic response to saline infusion in dogs. Clin. Sci. 36, 371-385, 1969.

27. Klainer, A. S., Gilliland, P. F., Cirksena, W. J., Bartelloni, P J.. and Beisel, W. R. - Serum glycoproteins in naturally-acquired malaria in man. Arch Int. Med. 123, 620-625, June 1969.

28. Fein, R. L., McNeil, J., Matsumoto, T., and Cirksena, W. J. - Renal function after extensive nephrotomy: comparison of suture and tissue adhesive closure techniques. (Abstract) Transactions of the American Society of Nephrology. 1968.

29. Tisher, C. C. and Cirksena, W. J. - Micropuncture sudy of subcellular localization of sodium (Na) binding sites in rat renal tubules (Abstract) Proceedings of International Congress of Nephrology, Stockholm, 1969.

30. Tisher, C. C., Cirksena, W. J., Arstilla, A. U., and Trump, B. F. - Sodium localization by electron microscopy and radioautography in single-perfused renal tubules. (Abstract) presented at the American Association of Pathologists and Bacteriologists, March, 1969, San Francisco CA, and published in Amer. J. Path., 55, #3, p. 19a, June 1969.

31. Tisher, C. C., Cirksena, W. J., Arstilla, A. U., and Trump, B. F. -Subcellular localization of sodium in normal and injured proximal tubules of the rat kidney. Am J. Path., 231-251, November 1969.

32. Tisher, C. C. and Cirksena, W. J. - Sodium (Na) localization by electon microscopy (E. M.) in single-perfused renal tubules. (Abstract) published in Proc. of Amer. Soc. Neph., November 1968.

33. Schrier, R. W., Regal, E. M., and Cirksena, W. J. - The role of aldosterone in the impairment of renal concentrating ability and improvement of diluting ability during prolonged sodium deprivation in chronic renal disease. (Abstract) Clin. Res, January 1969.

34. Cirksena, W. J., Keller, H. I., McNeil, J., and Schrier, R. W. - Micropuncture study of the importance of physical properties of blood in the response of the proximal tubule to volume expansion. (Abstract) Published in Proc. of Amer. Soc. of Neph. December 1969.

35. Cirksena, W. J. - Studies in experimental model of acute renal failure. Invited lecture. Paper presented at symposium of IV Medizinische Klinik of Nurnberg, Germany, December 12, 1969.

36. Cirksena, W. J., Lawson, N. L., McNeil, J. S., and Schrier, R. W. - Micropuncture study of altered blood composition in the depression of proximal reabsorption during volume expansion. (Abstract) Published in Proc. of Amer. Fed. Clin. Res. (National meeting) May 1970.

37. Tisher, C. C., Huddleston, M., and Cirksena, W. J. - An ultrastructural and histochemical investigation of potassium dichromate-induced cellular injury in single microperfused renal tubules. (Abstract) Pubished in Proc. of Amer. Assoc. of Path. And Bact. March 1970.

38. Schrier, R. W., Hano, J. E., Keller, H. I., Finkel, R., Gilliland, P. F., Teschan, P. E., and Cirksena, W. J. - Physiological response in military recruits during the early and late periods of summer basic training: potential implications in pathogenesis of acute renal failure associated with heat stress and exercise. Ann. Int. Med. 73:2, August 1970.

39. Canfield, D. J., Keller, H. I., and Cirksena, W. J. - Erythrokinetics during treatment of acute falciparum malaria. Milit. Med. 1971.

40. Cirksena, W. J., Bernier, G. W., Keller, H. I., and Teschan, P. E. - Pathogenetic studies in a model of pigment nephropathy in the rate. S. Karger.

41. Knepshield, J. H. and Cirksena, W. J. - Acute real insufficiency in Vietnam, Scientific Exhibit, American College of Physicians Annual Meeting, Denver CO, March 28 - April 2 1971, and American Medical Association Annual Meeting, May 1971. (Honorable Mention).

42. Cirksena, W. J. - A technique for fistulagrams in chronic renal failure patients. Presented IInd Annual Meeting International Society of Nephrology, Mexico City, 1972.

43. Cirksena, W. J. - Acute fluoride intoxication. Presented International Symposium on Fluoride; published in Proceedings of Symposium, Vienna, Austria. 1980.

Co-developer, with James H. Knepshield and Eric Lichtenstein, of an FDA-approved advanced computer-assisted hemodialysis system, supported by U. S. investors, an Israeli government grant, and Elron Industries

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