HSING-HUI “SAMMY” YU

***-*/*, ******** **.

KEARNY, NJ 07032-3014

(Cell) 201-***-**** (H)201-***-****

E-mail: acq01k@r.postjobfree.com

OBJECTIVE: Obtain a challenging position as a Research Chemist/analytical chemist/supervisor to expand my expertise and broaden the scope of my professional development.

SUMMARY

Experiences in applied chemical, R&D and pharmaceutical as a Lab Manager / Senior Chemist/ Chemical Engineer / Coating / Method Development and Validation / Analytical / Research / Quality Control Chemist with high-tech chemical and pharmaceutical firms.

PATENT

1.Patent No. US 7648603 Title: Colorless primer composition and method. Date Issued: January 19, 2010

2.Patent application No. 201******** Title: Method and Composition for Clearing Sewer Lines of Roots Utilizing Herbicides and Bacteria. Publication date: March 18, 2010

3.Patent No. 8986438: “An Improved Stainless Plumber’s Putty”. Date Issued: March 24, 2015

PAPER (Internal, NOT OFFICIAL PUBLISHED)

1.Determination of Organo-tin Levels in Polyols by Atomic Absorption Spectrometry and Tin Sample Preparation Solvents Review. Date Report: March 9, 2004 Hercules Chemical Company Inc.

2.Determination of 3-Iodo-2-propynyl N-butylCarbamate (IPBC) in Petrolatum wax by Gas Chromatography and Antimicrobial Zone Inhibition Test. Date report: Feb. 2014 Hercules Chemical

3.Validation for the HPLC Assay method for quantitative determination of Lorazepam and its related compounds in Ativan 0.5 mg Tablet Wyeth Pharmaceutical

INSTRUMENTATION

Skilled at operation/maintenance of state-of-the-art instrumentation including but not limited to GC, Bohlin Instrument, HPLC, GPC, IR, FTIR, AA (ICP) and UV/Vis Spectrometers, Electro Phoresis.

PROFESSIONAL EXPERIENCE

May, 2015 – MOW

Analytical:

Review USP 711: Dissolution

Review: A practical approach to validation of HPLC Methods under cGMP

-Validation requirements: (1) Robustness –pH, Temperature, % organic, Buffer concentration, column lot (2) Linearity (3)Accuracy/recovery study (4)Precision-repeatability(intra-day assay precision); Inter-mediate-precision (Inter-day variation); Reproducibility/Ruggedness (multiple Lab,multiple chemist test); (5)System sensitivity – LOD; LOQ (6)Specificity/Selectivity/Degradation (7)Test Range: (8)System suitability: HPLC-1 vs HPLC-2 – Tailing factor <2.5;Resolution factor >2.0; RSD of replicate injections <2.0%: Area; retention time

Review: HPLC Method parameters that can be varied:

-column length, inner diameter, particle size, temperature

-Mobile phase: pH, concentration of buffer salts, ratio of the solvents in the mobile phase

-System: Flow rate; Injection volume

Formulation: Lubricant formulation – Base oil + additives

Review Lubricant: Liquid; solid

Biolubricant: primarily triglyceride esters derived from plants and animals.

Lanolin Lubricant.

Review Base oil: Petroleum based –Mineral oil;

Non-petroleum based oil/Synthetic oils– Polyalphaolefins (PAO); naphthenics, synthetic

esters; phosphate esters; polyalkylene glycols (PAG);Silicate esters

Review: Additives for Crankcase Lubricant applications: Detergent additive; Dispersant additive; anti-wear additive; antioxidant additive; Viscosity Modifier; Pour point depressants; Foam inhibitors/antifoams; anticorrosion; antirust; seal swelling; biocide; demulsability

March 2014 – April 2015 Envirochem, Inc. South River, NJ

Product development Chemist/Formulation Chemist/Analytical Chemist: detergent, fabric softener, disinfectant and sanitization product for Hand, and Hard surface, cleaning product for oven, floor, fabric and more.

Develop and formulate hard surface or Hand cleaner use Nature essential oil, such as Thyme Oil, as a disinfectant; or, use Hydrogen Peroxide as a disinfectant.

Develop and formulate disinfectant liquid with Ammonium Chloride used in spray bottle or for disinfecting wipes.

Formulate sanitization liquid contain bleach for hard surface cleaning in spray bottle or in wipes; contain ethyl alcohol for hand cleaning in lotion form which mix with thickening agent.

Research and develop Lab size cleaning products, send out samples for customer testing, scale up test, and make production size based on customer request, Ex. 2000 gallon/batch.

Responsible for all new/improved product research, formulate, process and development activities.

Responsible for finding reasons and solve the problem if formulation product is out of specification.

Provide analytical or knowledge support for QC test. Such as titration, pH, viscosity test, Freezing test, GC, HPLC,UV/VIS, IR test.

Responsible for improving existing products for better performance.

Responsible for new product development, literature searching, request sample from raw material company, design experiments, product shelf life study, scale-up, plant production.

Responsible report written on product formulation procedure, condition, mixing time, batch size, QC test, color match, dye selection (water based or solvent based), perfume selection, essential oil application and safety.

Evaluate different emulsifier when mix with d-Limonene or methyl soyate,, their high end and low end cloudy point temperature, and their viscosity at different temperature and at different concentration.

Evaluate Enzyme, antibacterial ingredient, the performance when used in Laundry detergent and in cleaning products.

October 2002 – Jan 2014 Hercules Chemical Company Inc. Passaic, NJ

Senior Chemist - Research, New Product development, Formulation, Analytical, Tech Service in R & D Department

Responsible for all new/improved product research, formulate, process and development activities.

Provide analytical support, using GC, HPLC, UV/VIS, IR, Bohlin Malvern rheometer viscometer, Brookfield viscometer, titration, wet chemistry, to all departments corporation wide.

Develop/Validate HPLC, GPC, GC method.

Develop air spray product to Fresh air, to control smell, and leak detector spray product.

Develop anti-bacteria hand cleaning liquid used in Hand Towel, also develop GC analytical method to check anti-bacteria ingredient % in the cleaning liquid.

Develop anti-mold wax product, and develop GC method to check anti-mold ingredient % in wax product.

Develop boiler cleaner, formulate furnace cement and thread sealant.

Research, test and develop instrument and physical data such as Freeze temperature, viscosity at different temperature based on concentration on Propylene Glycol antifreeze, Ethylene Glycol antifreeze and glycerin antifreeze. And then develop GC method to check mixture of propylene glycol and ethylene glycol.

Research on antifoam and inhibitor to improve product performance.

Formulation new/upgrade existing products. In charge Pilot plant test for new products.

Oversee and perform quality control analysis. ISO9000 Internal Auditor.

Provide technical support .and answer customer technical questions by phone.

Design Sta Put putty with non-petroleum oil, non-fish oil, has at least 3 years high quality shelf life with cheaper price.

April 17, 2001 – October 2002 Wyeth Pharmaceutical Pearl River, NY

Analytical Chemist, Global Analytical Department

Assay, method development and validation using UV, GC, HPLC, HPLC with PDA (Photo Diode Array) detector

Raw materials: purity and impurity analysis.

Method development in pharmaceutical products which contain isolation of impurities and identification of related compounds.

Established GC and HPLC standard operating procedures.

Chromatographic data acquisition and data integration systems: Waters Millennium32; HP Chemstation; Perkin Elmer Turbo Chrom; ChemWindow)

Official scientific report written.

Familiar with cGMP and USP.

Responsibility on project:

- Method development and validation for the determination of Lorazepam and its related compounds in Ativan® Tablets by HPLC.

- Validation of USP method for the determination of Propranolol HCl in Inderal® Tablets by UV.

- Strength and identification of conjugated estrogens in Premarin Tablets by GC.

- Dissolution for Premarin Tablets, analysis by HPLC.

- Instrument Trainer (Waters HPLC)

1999- 2001 Hydromer (Bio-search), Inc. Branchburg, NJ

A bio-search and polymer company to develop new materials and application for customer in medical device, consumer, health care, cosmetic, and industrial coatings sectors.

Research Scientist, R & D Analytical Dept.

Assay development and validation using AA, UV, GC, FT-IR and HPLC

Supervision of coating solution production processes, coating application, formulation development, processes improvement, familiar mixing, blending, film coating.

Trouble shooting on analytical instruments and technical support to QC.

Quality Assurance – responsible to investigate out of specification (trend) results and issue investigation.

Responsible to solve customer complains.

Body lotion, skin cream, sunscreen formulation.

Research on Biostatic activity project: drugs such as antibiotics and/or antithrombogenics entrapped in thin coatings applied to the medical device surface (ex: catheter) and then kill bacteria.

1997 – 1999 New Jersey Inst. of Tech. Newark, NJ

Research Analytical/Process Chemist

Protein, Vitamin analyses by HPLC

Method development and validation use AA (ICP), UV, GC, TLC and HPLC

Data analysis and evaluation results on the research work.

Knowledge on statistical process control.

Report writing.

Teaching Assistant in Analytical and Organic Chemistry Courses.

Instructor on B.S. degree students on wet chemistry and analytical instrument, such as titration, sample extraction, metal analysis by AA (Atomic absorption), prepare samples, standards with Internal standard for instrument test such as IR, UV-VIS, GC and HPLC, and instruct students how to do spike study and unknown sample calculation.

1995-1997 Thomas Electronics Wayne, NJ

A privately held company was founded in 1948 to design, develop, and manufacture television picture tubes, industrial and military display cathode ray tubes (crts).

Chemist

Responsible for Phosphor formula development

Upgrade old slurry machine

General support for QC incoming phosphor (particle size)

Screen coating on prototype under customer request.

1990-1994 CasChem, Inc. Bayonne, NJ

A specialty chemical manufacturing company serving a wide variety of industries with a broad line of organic chemicals: Urethanes, Castor Oil and Chemical Derivatives (Ex: cosmetics, wax, soap).

Analytical Chemist: R & D department

Responsible for methods development including cosmetics field, molecular weight distribution (GPC) analyses and environmental compliance (waste water).

Provide analytical support to both the R&D and QC departments.

Develop methods as needed (wet, UV/VIS, GC, and HPLC) for the analysis of incoming materials, in-process compounds and products for the Quality Control and R&D departments.

Perform in-house environmental analysis (AA, FTIR, and GC) utilizing EPA methods.

Train technicians to perform analytical procedures utilized in the QC laboratory

GC, GPC, FTIR, and HPLC analysis to I.D. and characterize our products(Esters, Fatty Acid, amides, Hydrogenated Products, Urethanes, Polyols) and unknowns.

Report writing, data processing, trouble-shooting and maintenance instrument.

1988-1990 Combustion & Air Pollution Research Lab. Newark, NJ

New Jersey Institute of Technology (NJIT)

Graduate Research Assistant

HPLC method development for drug and food nutrient analyses (Ex: Analgesics, Barbiturates, and Vitamins C, D2, D3).

Kinetics & modeling for chemical activation analysis (IBM/PC, VAX).

Perform environmental analyses by GC, FTIR, UV/VIS and AA.

Responsible for maintenance, trouble-shooting for AA, GC and HPLC.

1985-1987` Johnson Pharmaceutical, Inc. Taiwan, R.O.C.

Quality Control Chemist

Sampling, analysis of raw materials and final products

Developed analytical processes for the qualification/quantification of drugs using analytical techniques (wet, UV/VIS, GC, and HPLC).

Performed chemical analysis of incoming and in process materials.

Implemented processes for the detection of small quantities of drugs in human bodily fluids.

Improved upon existing analytical procedures to achieve cost-effectiveness and reliability of results.

EDUCATION

M.S. 1994, Department of Management Engineering, New Jersey Institute of Technology, Newark, NJ

M.S. 1990, Department of Chemical Engineering, Chemistry and Environmental Science, New Jersey Institute of

Technology, Newark, NJ

B.S. 1983, Chemical Engineering Department, National Taipei Institute of Technology, Taiwan, R.O.C.

PATENTS by Inventor Hsing-Hui Yu

STAINLESS PLUMBER'S PUTTY

Patent No. 8986438

Abstract: A stainless putty composition is provided that includes a liquid portion including vegetable oil, and a solids portion. The solids portion includes one or more of a filler and polymeric plasticizer. The stainless putty composition is essentially free of hydrocarbons.

Type: Grant

Filed: February 20, 2012

Issued: March 24, 2015

Assignee: OATEY COMPANY

Inventors: Wayne A. Merrifield, Hsing Hui Yu

Method and Composition for Clearing Sewer Lines of Roots Utilizing Herbicides and Bacteria

Application number: 201********

Abstract: A foaming root destroyer is provided that utilizes a combination of herbicides and bacteria to inhibit and destroy the roots and fine root hairs intruding into underground discharge waste pipe systems. Furthermore, the foaming root destroyer can work over a longer period of time providing an enzymatic process to degrade and eliminate the dead root mass in the sewer line.

Type: Application

Filed: November 24, 2009

Issued: March 18, 2010

Inventors: Fred Richard Scholer, Hsing-Hui Yu, Raj Mehta

Colorless primer composition and method

Patent number: 7648603

Abstract: A primer formulated with a colorless dye detectable only under black light is provided. The present invention is non-detectable on a porous surface and color does not appear over time upon exposure to natural or synthetic lights. Under black light, sometimes referred to as ultra violet energy or long wave black light, the colorless dye appears as purple. However, once the black light is removed, the primer ceases to glow and returns to its natural, colorless state.

Type: Grant

Filed: August 2, 2006

Issued: January 19, 2010

Assignee: Hercules Chemical Company Incorporated

Inventors: Fred Richard Scholer, Hsing-Hui Yu, Wayne A. Merrifield

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