MICHAEL LAPE

Cell: 859-***-****

Covington, KY E-mail: acpwr3@r.postjobfree.com

Work Experience

Belcan Corporation Cincinnati, OH

Computer Specialist / System Administrator May 2011 – Dec. 2014

(Open Systems - Linux)

Managed backups of data for local offices as well as for 15 off-site locations and administrated

Linux-based backup management servers, EMC Networker on CentOS.

Fixed issues with backups, backup software, and Linux backup servers by working remotely on

software/OS via SSH as well as working with off-site technicians to solve physical issues with backup

hardware.

Promptly responded to user service requests, ITIL compliant, for recovery and/or restoration of files.

Worked on multiple web and desktop applications to support IT infrastructure for entire company

using shell scripting, Perl, PHP, MySQL, Java (JSP), HTML, and CSS.

Planned, developed, implemented, and administered an open source Linux-based 60 TB solution for

tertiary (nearline) storage, using CentOS and ZFS on Linux.

Managed multiple Linux web and database servers, a mix of CentOS, SLES, and openSUSE physical

machines and virtual machines (VMware), along with their hosted content, websites (Apache) and

databases (MySQL).

Assisted with administration of multiple Linux file servers (Samba / CIFS and limited NFS).

Networked machines via CAT6 or Fiber and completed some configuration of Cisco switches (mostly

VLAN changes). I have some networking experience, including layers 3 (IP), 4 (TCP/UDP), and the

application layer.

Northern Kentucky University Highland Heights, KY

Research Assistant May 2005 – Aug. 2010

Principal Investigator: Dr. Stefan Paula

Completed various biochemistry and medicinal chemistry research projects using both

computational and experimental methods.

These included CADD (computer-aided drug design) and subsequent experimental testing as well as

computer-aided specificity and affinity enhancement of an antibody (structure determined by

homology modeling) currently being experimentally tested in a graduate lab at The University of

Cincinnati.

Developed and tailored various experimental and computational protocols for our specific research

needs and capabilities.

Provided IT and software support for the entire laboratory.

Programmed and scripted various applications to automate and support molecular mechanics

simulations and subsequent analyses to streamline computational processes, using Java and C Shell.

EDUCATION

Northern Kentucky University Highland Heights, KY

Bachelor of Science [BS] Computer Science 2004 - 2009

GPA: 3.61

Graduated Cum Laude

Northern Kentucky University Highland Heights, KY

Bachelor of Science [BS] Biochemistry 2004 - 2009

GPA: 3.61

Graduated Cum Laude

Appointed to Two (2) Honor Societies:

Gamma Sigma Epsilon (Chemistry Honor Society)

Beta Beta Beta (National Biological Sciences Honor Society)

Information Technology Skills

Software

Microsoft Windows (95-8.1)

Linux (SUSE, openSUSE CentOS, RHEL, Ubuntu)

Microsoft Office Suite (2003-2013)

EMC Networker (Enterprise Backup Software)

LAMP Server (Linux, Apache, MySQL, PHP)

ZFS on Linux

SSH, FTP, SCP, RDP, VNC

Nagios, Zabbix

Programming/Scripting Language and Year of Last Use

Java 2010

C 2009

C++ 2009

Python 2013

PERL 2014

PHP 2014

HTML 2014

Shell (Bash, CSH, KSH) 2014

SQL (MySQL) 2014

Science Skills

Scientific Software (Used during Research Assistant Role)

Sybyl, MOE, GOLD (molecular docking), AutoDock, OpenEye Suite

QSAR and 3D-QSAR

MobyDigs, DRAGON, Sybyl COMFA and COMSIA

Chemdraw

Scientific Instrumentation and Methodologies (Used during Research Assistant Role)

Protein/Enzyme Extraction and Purification

Differential Centrifugation

Affinity Chromatography

Gel Electrophoresis (SDS-PAGE)

UV/Vis Spectrometry

Fluorescence Spectroscopy

NMR

96 Well Plate systems

GC-MS

LC

Scientific Publications

Elam C, Lape M, Deye J, Zultowsky J, Stanton DT, Paula S. Discovery of novel SERCA inhibitors by

virtual screening of a large compound library. Eur J Med Chem. 2011 May;46(5):1512-23.

Zacate M, Lape M, Stufflebeam M, Evenson W E. Modeling complex diffusion mechanisms in L12-

structured compounds. Hyperfine Interactions. 2010;197:219- 222.

Lape M, Elam C, Paula S. Comparison of current docking tools for the simulation of inhibitor binding

by the transmembrane domain of the sarco/endoplasmic reticulum calcium ATPase. Biophys Chem.

2010 Aug;150(1-3):88-97.

Lape M, Paula S, Ball WJ Jr. A molecular model for cocaine binding by the immunotherapeutic

human/mouse chimeric monoclonal antibody 2E2. Eur J Med Chem. 2010 Jun;45(6):2291-8.

Paula S, Abell J, Deye J, Elam C, Lape M, Purnell J, Ratliff R, Sebastian K, Zultowsky J, Kempton RJ.

Design, synthesis, and biological evaluation of hydroquinone derivatives as novel inhibitors of the

sarco/endoplasmic reticulum calcium ATPase. Bioorg Med Chem. 2009 Sep 15;17(18):6613 -9.

Deye J, Elam C, Lape M, Ratliff R, Evans K, Paula S. Structure-based virtual screening for novel

inhibitors of the sarco/endoplasmic reticulum calcium ATPase and their experimental evaluation.

Bioorg Med Chem. 2009 Feb 1;17(3):1353-60.

Lape M, Elam C, Versluis M, Kempton R, Paula S. Molecular determinants of sarco/endoplasmic

reticulum calcium ATPase inhibition by hydroquinone-based compounds. Proteins. 2008 Feb

15;70(3):639-49.

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