J O N AT H A N P O P O V I T C H

**** ***** ****** ****** *****: 609-***-****

Philadelphia, PA 19123 Email: acpsvw@r.postjobfree.com

R ADIOPHARMACEUTICAL DEVELOPMENT CHEMIST

Certified radiology safety officer and chemist inventing products and streamlining processes. Adept at laboratory

management and extensively trained in safety, equipment maintenance, synthesis, cGMP pre-clinical and clinical

studies. Lead research and production labs while overseeing safety in daily operations for 30 radioactivity users on site

and around the world.

AREAS OF EXPERTISE

Organic & Inorganic Chemistry HPLC Purification Texture Analyzer

TLC Analysis & Purification NMR Analysis GLP/GMP Environment

Compound Optimization Pilot Lab Production Infrared Classification

Chemical Synthesis Design Procedures Chromatology

KEY SKILLS ASSESSMENT

EXPLORATORY INVESTIGATION - Aseptic manipulation of injectable pharmaceuticals.

MOTIVATED - Request additional responsibilities to better serve company needs.

PROFESSIONAL EXPERIENCE

2011 - Present

AVID RADIOPHARMACEUTICALS, ELI LILLY & COMPANY, Philadelphia, PA

RADIOPHARMACEUTICAL DEVELOPMENT CHEMIST & RADIATION SAFETY OFFICER

Manufacture clinical radiopharmaceuticals for injection delivery systems for imaging the progression of Alzheimer’s disease.

Support exploratory investigational new drug (eIND) and traditional investigational new drug (IND) studies.

Synthesize radioactive 18F compounds using different radiosynthesizers, and manual synthesis to develop potential brain

imaging compounds. Author pertinent manufacturing SOPs as well as radiation safety SOPs. Ensure data quality and accuracy

of laboratory notebook entries, reports, SOPs, and batch records in compliance with cGMPs and SOPs.

Prepare and analyze pre-clinical radioactive 125I compounds through manual synthesis. Oversee radiation safety aspects of

everyday operations and manage associated documents and archives. Perform manual aseptic compound sampling in Class 100

sterile clean room to ensure injectable product is sterile and safe for human use. Utilize visual management tools to clearly

display critical safety, production, and laboratory operations.

KEY ACHIEVEMENTS:

Safety leader for research and production labs.

Successfully synthesized eIND clinical materials that have never been injected into human patients.

FMC CORPORATION, Ewing Township, NJ 2010 - 2011

DEVELOPMENT SCIENTIST

Mentored and trained personnel in patented process for pilot and manufacturing duties. Controlled and maintained an R&D

encapsulation process for carrageenan (non-animal gelatin substitute) formulations. Evaluated possible processes to enter the

pharmaceutical market by obtaining approval for GMP and GLP processes. Verified all specifications for equipment and raw

products met customer requirements. Analyzed product properties such as disintegration, hardness/burst tests, pH, elasticity,

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Jonathan Popovitch

color, gradient profiles, viscosity, and particle size.

KEY ACHIEVEMENTS:

Designed start-up procedures for manufacturing of the scaled-up encapsulation process for facilities in the United

States and overseas.

Determined possible process and encapsulation parameters by mixing temperature, pressure, shear, time, encapsulation

speed, injection time, and delay time.

Monitored full plant operations of extraction process of carrageenan from raw material.

DREXEL UNIVERSITY, Philadelphia, PA 2009 - 2011

INORGANIC SYNTHETIC CHEMIST

Handled projects independently. Analyzed newly formed compounds using X-ray crystallography. Prepared scientific journal

articles. Interpreted X-ray crystallographic structures.

KEY ACHIEVEMENTS:

Developed numerous synthesis experiments in their entirety including creation of unique organic ligands and metal

complexes utilizing various metal to ligand combination reactions, assisting graduate students with their theses and

resulting in a publication.

Authored new rhodium complex research paper published in the “Journal of Chemical Crystallography,” resulting in

synthesizing a new compound.

AMICUS THERAPEUTICS, Cranbury, NJ

2008

ORGANIC SYNTHETIC CHEMIST (CO-OP)

Assisted in pre-clinical Parkinson's chemical research. Purified compounds using method that included flash columns, gradient

columns, and reverse phase columns. Conducted thin layer chromatography research analysis to ensure materials were within

the expected range and purity of synthesized compound. Conducted analytical chemistry experiments using NMR, High

Pressure Liquid Chromatography, and Mass Spec. Presented weekly updates.

KEY ACHIEVEMENTS:

Developed full synthetic route to a desired target compound; results were pending upon return.

Carried out numerous organic reactions such as Grignard additions, Suzuki coupling, and demethylating using boron

tribromide, resulting in possible drug compound for Parkinson’s Disease.

JOHNSON MATTHEY, West Deptford, NJ

2007

REFINING AND DEVELOPMENT CHEMIST (CO-OP)

Led independent projects and managed multiple projects, including reporting. Implemented scale-up chemical procedures and

processes for pilot plant operations. Created products and conducted analytical experiments according to customer

specifications.

KEY ACHIEVEMENTS:

Developed procedures and experiments to be implemented on larger scale production process such as ruthenium

recovery from a 10,000-gallon batch of a failed production run, saving the company almost $3 million.

EDUCATION & TRAINING

Bachelor of Science, Chemistry, Drexel University, Philadelphia, PA, 2010

Certified Radiation Safety Officer, DOT & IATA Class 7 HAZMAT/ Radioactive material shipments,

Dade Moeller Radiation Safety Academy, 2012 and 2015

MEMBERSHIPS & P UBLICATIONS

VICE PRESIDENT, AMERICAN CHEMICAL SOCIETY, DREXEL CHAPTER

Popovitch J, Addison A, Butcher R, Prushan M (2011). The 1,8-bis(2'-pyridyl)-3,6-dithiaoctane complex of rhodium(III).

Journal of Chemical Crystallography. 2010

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