Ian David Tomlinson, PhD, MSc, BSc, MRSC

Apartment 109, 2112 Fairfax Avenue ~ Nashville, Tennessee 37212 USA

Home: 615-***-**** ~ aco33e@r.postjobfree.com

QUALIFICATIONS PROFILE

Organic Chemistry ~ Medicinal Chemistry ~ Biological Chemistry ~

Environmental Science

Highly determined and innovative professional with a strong research

background in organic and medicinal chemistry combined with unique

expertise in the development of drug conjugates for quantum dots published

in peer-reviewed journals. Brings a highly results-driven approach with a

keen ability to drive creative solutions to research challenges. Self-

directed problem solver who works well independently. Holds a PhD degree in

Biological Chemistry with a master's in Environmental Diagnostics. Willing

to relocate. Additional expertise includes:

Drug Conjugates for Quantum Dots Fluorescent Substrate Development

High Throughput Assays Ligand Development

Process Development & Synthesis Biologically Active Molecules

Alzheimer's / Neuroscience Environmental Diagnostics

EDUCATION & CREDENTIALS

MSc, Environmental Diagnostics, 1999 - Cranfield University, Beds, UK

PhD, Biological Chemistry, 1989 - The University Of Essex, Colchester,

Essex, UK

BSc (Hons), Biological Chemistry, 1985 - The University Of Essex,

Colchester, Essex, UK

6 'O' Levels / 4 'A' Levels, 1982 - Bosworth College, Desford,

Leicestershire, UK

PROFESSIONAL EXPERIENCE

Vanderbilt University, The Department Of Chemistry, Nashville, TN, USA

(1999 - Present)

Research Assistant Professor (2004-Present)

Research Associate (2000-2004)

Postdoctoral Research Fellow (1999-2000)

Oversee daily management of organic/medicinal chemistry aspects while

serving on a multidisciplinary team comprised of physical chemists and

pharmacologists. Conceived and implemented a methodology for attaching

drugs and peptides to fluorescent nanocrystals. Manage design and synthesis

of biologically active ligands. Lead a group of student researchers engaged

on this project.

Key Achievements:

. Spearheaded the development of a fluorescent probe used as a

fluorescent assay in high throughput assays for the biogenic monoamine

transporters, such as the serotonin transporter (SERT) dopamine

transporter (DAT) and the norepinephrine transporter (NET). Received

U.S. patent and currently on the market.

. Innovated multiple novel probes which may be conjugated to fluorescent

substrates such as quantum dots with further usage for imaging

membrane distribution and dynamics of the monoamine transporters.

. Produced several articles published in peer-reviewed journals.

. Overcame the challenges of non-specific binding of quantum dot to cell

membrane surfaces by integrating polyethylene glycol linkers in

ligands.

LAMAS Resources Ltd., Corby, Kettering, UK (5/1999 - 8/1999)

MSc Project Placement

Conducted analysis of process parameters of thermophillic fermentation of

putrecible waste.

Key Achievements:

. Identified improvements to plant operating procedures that lowered

process costs.

Ian David Tomlinson, PhD, MSc, BSc, MRSC

Page 2 of 5

Key Organics Ltd, Camelford, Cornwall, UK (1/1998 - 10/1998)

Senior Scientist

Performed synthesis of compounds for a compound library and custom

synthesis.

ASTRA Arcus AB, London, UK & S dertalje, Sweden (1989 - 1997)

Scientist (1996-1997) S dertalje, Sweden

Implemented synthesis of compounds with affinity for the serotonin

transporter (SERT) and the 5HT1 receptor.

Scientist, Neuroscience Research Unit (1989-1996) London, UK

Played a key role in the development of compounds to treat Alzheimer's

disease which were inhibitors of the enzyme acetyl choline esterase.

Key Achievements:

. Received patent for a drug that was structurally similar to many

current Alzheimer's treatments.

Rhone Poulenc Rhorer, Ongar, Essex, UK (5/1988 - 8/1988)

Industrial Placement in Chemistry

Rhone Poulenc Rhorer, Ongar, Essex, UK (1/1987 - 4/1987)

Industrial Placement in Biochemistry

The University Of Newcastle, The Department of Agricultural Biology,

Newcastle, UK (1985 - 1986)

Junior Research Assistant

RESEARCH SKILLS

. Multi-step organic synthesis, HPLC, preparative HPLC, GC, GC-Mass Spec,

MALDI mass spectroscopy, GC-IR, IR, UV-Vis, NMR, TLC, preparative

. Pegilation, gel electrophoresis, size exclusion chromatography, ion

exchange chromatography, aseptic techniques, PCR, affinity chromatography

. Chemx, Hyperchem, Chem Draw, Isis Draw, Alchemy

. Microsoft Word, Microsoft Excel, Microsoft PowerPoint, BIDS

. QSAR analyses using the method developed by Hansch and Simplex method

. ISIS Base, Belstein, Scifinder, Chembase, Microsoft Access

. Experience operating a thermophillic digester of putrescible organic

waste.

REFERENCES

. Anthony P. Gies

Senior Analytical Chemist

The Dow Chemical Company

2301 N. Brazosport Blvd. B-1219

Freeport, TX 77541-3257

Phone: 979-***-****

E-mail: aco33e@r.postjobfree.com

. Professor Todd Georgio

Chair of Biomedical Engineering

Vanderbilt University

E-mail: aco33e@r.postjobfree.com

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