Weiwei Duncan

acgbs3@r.postjobfree.com / ***** Franklin Road Apt 120, Southfield, MI, 48034

Highly motivated and detail-oriented chemist has extensive lab training in organic chemistry, analytical

chemistry, biochemistry.

Skills

Lab Techniques

High-Pressure Liquid Chromatography (HPLC), LC-Mass Spectrometry, Protein purification, Thin

Layer Chromatography (TLC), Ion Exchange Chromatography, UV-spectroscopy, Fourier

Transform Infrared Spectroscopy (FT-IR), NMR spectroscopy, Titration, PH measurement, Ultra-

Pressure Liquid Chromatography (UPLC), optical rotation, analytical method development, data

analysis, organic synthesis, sample preparation, inventory management, equipment

maintenance

Computer Skills

MS Word, MS Excel, MS Powerpoint, EndNote, Chemdraw, ACD NMR processor, Adobe

Photoshop CC, amateur web designer

Education

Wayne State University Sep 2011-April 2014, GPA=3.95

M.S. in Chemistry

University of Science and Technology of China (USTC) Sep 2005-June 2009

B.S. in Biological Sciences

Professional Experience

Wayne State University (May 2012-April 2014)

Graduate Research Assistant

- Finished organic synthesis of a series of 4'-O-Paromomycin derivative antibiotics. The

antibiotics were purified with TLC, HPLC, ion-exchange chromatography and characterized

with high resolution LC-MS, NMR.

- Created and maintained sample inventory; Prepared and Shipped Samples to our

collaborator for pharmaceutical profile characterization (activity, toxicity, ect).

- Responsible for the maintenance of LC-MS, HPLC equipments, lab chemical inventory

management, chemical reagent purchase, training intern students.

- Initiated a collaboration project at the interface of organic chemistry and analytical chemistry

with another research group and lead the project between several team members.

- Finished organic synthesis and purification of a series of carbohydrate synthesis

intermediates with HPLC; Prepared the sample for mass spectrometry characterization.

- Developed a quantitative analytical method to do quality test of carbohydrate synthesis

intermediates using both LC-Mass Spectrometry cone voltage fragmentation method and

collision induced collision (CID).

- Data analysis of the experiment results with Microsoft Excel.

Wayne State University (Sep 2011-April 2012)

Graduate Teaching Assistant

- Taught an advanced organic lab for two groups of undergraduate students, who were mostly

in pre-medical or pre-pharmacy programs. Students were trained with basic lab skills like

filtration, recrystallization, gas chromatography, etc.

- Gave quiz lectures on organic chemistry class for three groups of undergraduate students.

Portland State University (Aug 2010-Aug 2011)

Research Assistant Intern

- Finished organic synthesis of salophene to detect tumor biomarkers.

- The organic compound was purified with TLC, liquid chromatography and characterized with

LC-MS and NMR.

Laboratory of Biomacromolecule Crystallography USTC (Jul 2008-June 2009)

Intern

- Finished protein expression of hPRS2 in E.coli system.

- Purified the protein with metal-affinity chromatography, size-exclusion HPLC, Hydrophobic

Interaction Chromatography subsequently.

- Prepared the sample in buffer solution; screened crystallization condition of the protein

sample.

Publications

-“Synthesis, Antiribosomal and Antibacterial Activity of 4’-O-Glycopyranosyl Paromomycin

Aminoglycoside Antibiotics” Chen, W.; Matsushita, T.; Shcherbakov, D.; Boukari, H.; Vasella, A.;

Böttger, E.; Crich, D. Medchemcomm, 2014.

-Zhihua Yang, Weiwei Chen, David Crich, Mary Rodgers, “The Effects of Linkage

Stereochemistry and Protecting Groups on Glycosidic Bond Stability of Sodium Cationized

Glycosyl Phosphates” ASMS conference 2014, No1674.

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