SHEKHAR SRIVASTAVA, PhD.

*** ****** ******, ********, ** 07041 718-***-**** acfuoe@r.postjobfree.com

OBJECTIVE

Highly motivated, dedicated, results-oriented individual with extensive expertise in multiple

therapeutic areas, possessing excellent communication and interpersonal skills seeks a consulting

position focusing on science, strategy and technology in the biotech/pharmaceutical/healthcare sector

PROFESSIONAL EXPERIENCE

2006-present RESEARCH ASSISTANT PROFESSOR, SKIRBALL INSTITUTE, NYU SCHOOL OF MEDICINE, NEW YORK

• Conceptualized, designed and lead investigations on several research projects to evaluate ion

channels across multiple therapeutic areas using innovative research platforms

o Immunology, inflammation, cardiology, colitis, diabetes, and polycystic kidney

disease

• Adept at project management; s killed at multi-tasking and meeting deadlines in a

fast paced environment both independently and in a team based setting

• Possess strong qualitative and quantitative abilities; adept at formulating hypothesis, collecting and analyzing data,

and drawing conclusions

• Strong critical thinking, analytical and trouble shooting skills; proficient in technical

writing and presentation

Proficient at synthesizing scientific data for educational initiatives and

o

developing strategic reports

o Extensive experience in the research, development, writing, and editing of

scientific manuscripts, posters, abstracts, and slide decks

o Authored well-cited publications in peer-reviewed journals

Presented data to both internal and external audience

o

• Mentored lab technicians, post-doctoral and clinical research fellows.

2004-2006 RESEARCH SCIENTIST, DEPARTMENT OF MEDICINE, SKIRBALL INSTITUTE, NYU SCHOOL OF MEDICINE.

• Elucidated novel signaling pathways involving ion channels in cancer, autoimmune diseases

and accelerated atherosclerosis

• Established electrophysiology and imaging platforms and related operating procedures

• Published extensively in prestigious peer reviewed journals

2001.2004 POST DOCTORAL RESEARCH FELLOW, PEDIATRIC CARDIOLOGY, NYU SCHOOL OF MEDICINE, NEW YORK

• Established a novel therapeutic strategy to prevent heart failure in infants

• Investigated the regulation of contractile strength during neonatal development and regulation of ion channels and

exchangers by interacting proteins

• Developed analytical and problem solving skills, as well as excellent verbal and written communication skills

1997-2001 RESEARCH FELLOW, DIVISION OF PHARMACOLOGY, CENTRAL DRUG RESEARCH INSTITUTE, LUCKNOW, INDIA

• Elucidated a mechanism of calcium homeostasis in hamster heart

• Conducted lead identification, validation and optimization as part of cardiovascular drug

discovery

• Established collaborations both internal and external

EDUCATION

• 2002 PhD (Biochemistry) Central Drug Research Institute and Dr. RML Avadh Univ, Faizabad

• 1996 MSc (Biochemistry) Dr. RML Avadh Univ, Faizabad, India

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SELECTED ACADEMIC AND PROFESSIONAL HONORS

2012 Patent for PI3KC2β as a potential new pharmacologic target to treat IgE-mediated

disease.

2012 Robert S. Holzman Award for Best poster, Medicine day, NYU Langone Medical center.

2009 Reversible Histidine phosphatase work cited as “Perspectives” in Science signaling

2007 Publication on phosphorylation of KCa3.1 by a Histidine kinase, Science STKE Editor’s choice

for best paper

2002 Junior Scientist award in Pharmacology from Association of Scientists of Indian Origin in America

1998 Senior Research fellowship award from Council of Scientific and Industrial Research

PUBLICATIONS

• Authored several book chapters and highly cited scientific papers in prestigious peer-reviewed

journal articles (Details in Appendix 1)

APPENDIX 1

SHEKHAR SRIVASTAVA, PhD.

157 Myrtle Avenue, Millburn, NJ 07041 718-***-**** acfuoe@r.postjobfree.com

PUBLICATIONS

Published book chapters and highly cited scientific papers in prestigious scientific publications

Book chapters

1) Salvatore Mancarella, Shekhar Srivastava, Anita Go, Ying-Ying Zhou, William A Coetzee,

Michael Artman. Changes in excitation-contraction coupling during mammalian development:

implications for regulation of contractile function. In: Artman M, Cardiovascular development

and congenital malformations. Blackwell publishing; 2005:190.

2) Srivastava S, Nakamura TY, Coetzee W, Artman M. Role of the sodium-calcium exchanger in

contraction and relaxation in immature ventricular myocytes. In: Singal PK et al., Cardiac

Remodeling and failure. Kluwer Academic Publishers, Boston; 2002:355-363.

Scientific papers

1) Xinjiang Cai, Shekhar Srivastava, Sheena Surindran, Zhai Li, Edward Y Skolnik. Regulation of

the epithelial Ca channel TRPV5 by reversible histidine phosphorylation mediated by NDPK-B

and PHPT1. Molecular Biology of the Cell 2014;25(8):1244-50.

2) Shekhar Srivastava, Xinjiang Cai, Yi Sun, Zhai Li, Edward Y Skolnik. Phosphatidylinositol-3-

kinase C2β and TRIM27 play critical roles in positively and negatively regulating mast cells.

Molecular and Cellular Biology 2012;32(15):3132-9.

3) Xinjiang Cai, Shekhar Srivastava, Yi Sun, Zhai Li, Haiyan Wu, Ljiljana Zuvela-Jelaska, Jun Li,

Rachel S. Salamon, Jonathan M. Backer, Edward Y Skolnik. TRIM27 negatively regulates CD4

T cell activation via the ubiquitination and inhibition of PI3KC2β. Proc Natl Acad Sci U S A.

2011;108(50):20072-7.

4) Olga Zhdanova, Shekhar Srivastava, Lie Di, Leila Tchelebi, Sara Dworkin, Reelina Chatterjee,

Lawrence B. Holzman, Laura Barisoni, and Edward Y Skolnik. Deletion of Drosha In Podocytes

Results In Collapsing Glomerulopathy. Kidney International 2011;80(7):719-30.

5) Lie Di, *Shekhar Srivastava, Olga Zhdanova, Yi Sun, Zhai Li, Edward Y Skolnik. Nucleoside

diphosphate kinase B knockout mice have impaired activation of the K+ channel KCa3.1

resulting in defective T cell activation. Journal of Biological Chemistry 2010;285(50):38765-71.

*co-first author.

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6) Lie Di, Shekhar Srivastava, Olga Zhadnova, Yi Ding, Zhai Li, James Melvin, Heike Wulff,

Maria Lafaille, and Edward Y. Skolnik. Inhibition of the K + Channel KCa3.1 Ameliorates T Cell

Mediated Colitis. Proc Natl Acad Sci U S A. 2010;107(4):1541-6.

7) Shekhar Srivastava, Zhai Li, Santosha Vardhana, Michael l Dustin, Edward Y Skolnik.The class

II Phosphatidylinositol 3 phosphate C2 beta is required for the activation of the K + channel

KCa3.1 and the subsequent activation of CD4 T cells. Molecular Biology of the Cell

2009;17:3783-91.

8) Shekhar Srivastava, Olga Zhadanova, Zhai Li, Mamdouh Albaqumi, Heike Wulff, Edward Y

Skolnik. Protein histidine phosphatase 1 negatively regulates CD4 T-cells by inhibiting the K +

channel KCa3.1. Proc Natl Acad Sci U S A. 2008;105(38):14442-6.

9) Mamdouh Albaqumi, *Shekhar Srivastava, Darren Wallace, Edward Y. Skolnik.

Pharmacological Inhibition of KCa3.1 as a Potential Therapy for Polycystic Kidney Disease.

Kidney Int. 2008;74(6):740-9. *co-first author.

10) Shekhar Srivastava, Steven E Cala, William A Coetzee, Michael Artman. Phospholemman expression is high in

the newborn rabbit heart and declines with postnatal maturation. Biochem Biophys Res Commun

2007;355(2):338-41.

11) Leon Collis, Shekhar Srivastava, William A Coetzee, Michael Artman. Beta-2-adrenergic

receptor signaling stimulates L-type calcium current independent of PKA in neonatal rabbit

ventricular myocytes. Am J Physiol Heart Circ Physiol. 2007;293(5):H2826-35.

12) Shekhar Srivastava, Papiya Choudhury, Zhai Li, Gong Xin Liu, Vivek Nadkarni, Kyung Ko,

William A Coetzee, Edward Y Skolnik. Phophatidylinositol (3) Phosphate indirectly activates

KCa3.1 via 14 amino acids in the carboxyterminus of KCa3.1. Molecular Biology of the Cell

2006;17(1):146-154.

13) XiaoYong Tong, Lisa M Porter, GongXin Liu, Piyali Dhar-Chowdhury, Shekhar Srivastava,

David J Pountney, Hidetada Yoshida, Michael Artman, Glenn I Fishman, Cindy Yu, Ramesh Iyer,

Gregory E Morley, David E Gutstein, William A Coetzee. Consequences of cardiac myocyte-

specific ablation of KATP channels in transgenic mice expressing dominant negative Kir6 subunits.

Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H543-51.

14) Shekhar Srivastava, Kyung Ko, Papiya Choudhury, Zhai Li, Amanda K. Johnson, Vivek

Nadkarni, Derya Unutmaz, William A. Coetzee, Edward Y. Skolnik. The Phosphatidylinositol-3

phosphate myotubularin related protein negatively regulates CD4 T cells. Molecular and Cellular

Biology 2006;26(15):5595-602.

15) Papiya Choudhury*, Shekhar Srivastava*, Zhai Li, Kyung Ko, Mamdouh Albaqumi, Kartik

Narayan, William A. Coetzee, Mark A. Lemmon, and Edward Y. Skolnik. Specificity of

Myotubularin Family of Phosphatidylinositol-3 Phosphatase is Determined by the GRAM/PH

Domain. Journal of Biological Chemistry 2006;281(42):31762-9. *co-first Author .

16) Shekhar Srivastava, Zhai Li, Kyung Ko, Papiya Choudhury, Mamdouh Albaqumi, Amanda K.

Johnson, Ying Yan, Jonathan Backer, Derya Unutmaz, William A. Coetzee, and Edward Y.

Skolnik. Histidine Phosphorylation of the Ca 2+-Activated K+ Channel KCa3.1 by Nucleoside

Diphosphate Kinase B (NDPK-B) is Required for KCa3.1 Channel activation and the

Reactivation of CD4 T Lymphocytes. Molecular Cell 2006;24(5):665-75.

17) Piyali Dhar Chowdhury, Maddison Harrell, Sandra Han, Danuta Jankowska, Lavanya Parachuru,

Alison Morrissey, Shekhar Srivastava, Weixia Liu, Brian Malester, Hidetada Yoshida, William

A. Coetzee. The molecular basis for the regulation of K ATP channels by glycolytically-derived

ATP. Journal of Biological Chemistry 2005;280(46):384**-*****.

18) Shekhar Srivastava, Zhai Li, Lin Lin, Gong Xin Liu, Kyung Ko, William A Coetzee, Edward Y Skolnik. The PI3P

phosphatase myotubularin related protein 6 (MTMR6) is a negative regulator of the Ca 2+-activated K+ channel

KCa3.1. Molecular and Cellular Biology, 2005;25(9): 3630-3638.

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19) Alison Morrissey, Lavanya Parachuru, Monika Leung, Gwendolyn Lopez, TY Nakamura, Xiao

Yong Tong, Hidetada Yoshida, Shekhar Srivastava, Piyali Dhar Chowdhury, Michael Artman,

William A Coetzee. Expression of KATP channel subunits during perinatal maturation in the mouse

heart. Pediatr Res, 2005;58(2):185-92.

20) Shekhar Srivastava, Leon Collis, Anita Go, Salvatore Mancarella, William A Coetzee, Michael

Artman. Paradoxical effect of dofetilide on action potential duration and calcium transient

amplitude in newborn rabbit ventricular myocytes. J Cardiovasc Pharmacol, 2005;45(2):165-174.

21) Go Anita, Srivastava S, Collis L, Coetzee WA, Artman M. Negative inotropic effect of

nifedipine in the immature rabbit heart is due to shortening of the action potential. Pediatric

Research, 2005;57(3):399-403.

22) Ray M, Roy R, Chowdhury PD, Srivastava S, Dubey MP. The hamster heart: a paradox in itself.

Pharmacological Research, 2000;41(3):361-367.

23) Ray M, Srivastava S, Maitra SC, Dubey MP. The hamster heart is resistant to calcium paradox.

Pharmacological Research, 2000;41(4):475-481.

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