Yuangen Chen

ACADEMIC APPOINTMENTS

Assistant Professor Department of Neurosurgery, the Mount

Sinai School of Medicine

New York, NY 10029

(September, 2007- Present)

Research Associate Department of Microbiology and Immunology,

New York Medical

College New York, NY 10595

(2001-2005)

Associate Professor Division of Gastroenterology, Huashan

hospital, Shanghai, China

(1996-1998)

Assistant Professor Division of Gastroenterology, Huashan

hospital, Shanghai, China

(1994-1996)

HOSPITAL APPOINTMENTS

Attending staff (IOM) Department of Neurosurgery, the Mount Sinai

Hospital

New York, NY 10029 (December,

2007- Present)

Assistant Attending Department of Neurosurgery, the Mount

Sinai Hospital

New York, NY 10029

(September, 2005- Dec. 2007)

Research Coordinator Department of Neurosurgery, Mount Sinai

School of Medicine

New York, NY 10029 (January,

2005-Sept.2005)

Associate Professor Division of Gastroenterology, Huashan

hospital, Shanghai, China

(1996-1998)

Assistant Professor Division of Gastroenterology, Huashan

hospital, Shanghai, China

(1994-1996)

EDUCATION

Ph.D. Division of Gastroenterology, Huashan hospital, Shanghai, China

(1994)

M.D. Jiangxi Medical College, Jiangxi, China (1986)

POSTDOCTORAL TRAINING

Postdoctoral fellow Department of Microbiology and Immunology,

New York Medical

College, New York (1998-

2001)

Residency Department of Medicine, Dongxiang Hospital, Jiangxi,

China (1986-1989)

HONORS/AWARDS

ABNM Member eligible (written part exam passed)

ASNM Member American Society of Neurophysiological Monitoring

(2005-Present)

CNIM Certificate (#1132) (2006-2016)

95-96's Excellent Physician Hushan Hospital, Shanghai, China

(1996)

Top Prize the third national award of Omeprazole research,

Chinese Digestive Association,

Wuhan, China (1995)

EXPERIENCES (2005, Jan.-Present)

Supervising intraoperative monitoring of brain, spinal cord, and peripheral

nervous system during neurosurgical procedures using somatosensory evoked

potentials (SSEPs), brainstem auditory evoked potentials (BAEPs), motor

evoked potentials (MEPs), electroencephalogram (EEG), as well as free-run

and electrically-triggered electromyography (EMG) for monitoring segmental

motor nerve root function

PUBLICATIONS

Peer Reviewed Original Contributions

1. Kumar A, Chen Y, Lin HM, Deiner S. Elevated preoperative blood

pressure predicts the intraoperative loss of SSEP neuromonitoring

signal during spinal surgery. J Clin Monit Comput. 28:187-192(2013)

2. Tadi K, Ashok BT, Chen Y, Banerjee D, Wysocka-Skrzela B, Konopa J,

Darzynkiewicz Z, Tiwari RK. Pre-clinical evaluation of 1-

nitroacridine derived chemotherapeutic agent that has preferential

cytotoxic activity towards prostate cancer. Cancer biology & therapy.

Oct.6(10):1632-1637(2007)

3. Ashok B.T., Tadi K, Garikapaty, V.P.S., Chen Y., Huang Q., Banerjee

D., Konopa J., Tiwari R.K. Preclinical toxicological examination of a

putative prostate cancer-specific 4-methyl-1-nitroacridine derivative

in rodents. Anticancer Jan;18(1):87-94(2007)

4. Tadi K, Chang Y, Ashok B.T., Chen Y, Moscatello A, Schaefer S.D.,

Schantz S.P., Policastro A.J., Geliebter J, Tiwari R.K. 3,3'-

Diindolylmethane, a cruciferous vegetable derived synthetic anti-

proferative compound in thyroid disease. Biochem Biophys Res Commun.

Nov 25;337(3):1019-25 (2005)

5. Suriano R, Ghosh S.K., Ashok B.T., Mittelman A, Chen Y.G., Banerjee

A, Tiwari R.K. Differences in Glycosylation Patterns of Heat Shock

Protein, gp96: Implications for Prostate Cancer Prevention. Cancer

Res. Jul 15; 65(14): 6466-75 (2005)

6. Garikapaty, V.P.S., Ashok, B.T., Chen, Y.G., Mittelman, A.,

Iatropoulos, M., and Tiwari R.K. Anti-carcinogenic and anti-

metastatic properties of indole-3-carbinol in prostate cancer. Oncol

Rep. Jan; 13(1):89-93 (2005)

7. Chen, Y.G., Ashok, B.T., Liu, X., Garikapaty, V.P.S., Mittelman, A.

and Tiwari, R.K. Induction of heat shock protein, gp96, by immune

cytokines. Cell Stress & Chaperones 8(3), 242-248 (2003)

8. Ashok, B.T., David, L., Chen, Y.G., Garikapaty, V.P.S., Chander, B.,

Kanduc, D., Mittelman, A. and Tiwari, R.K. Peptide mimotopes of

oncoproteins as therapeutic agents in breast cancer. Int. J. Mol.

Med. 11: 465-471 (2003)

9. Ashok, B.T., Chen, Y.G., Liu, X., Garikapaty, V.P.S., Seplowitz, R.,

Tschorn, J., Roy, K., Mittelman, A. and Tiwari, R.K. Multiple

molecular targets of indole-3-carbinal, a chemopreventive

antiestrogen in breast cancer. Eur. J. Cancer Prev. 11: S86-S93

(2002)

10. Ashok, B.T., Chen, Y.G., Liu, X., Bradlow, H.L., Mittelman, A. and

Tiwari, R.K. Abrogation of estrogen mediated cellular and

biochemical effects by indole-3-carbinol.

Nutrition and Cancer. 41: 180-187 (2002)

11. Wang, L., Lu, W., Chen, Y.G., Zhou, X.M. and Gu, J.R. Comparision of

gene expression between normal colon mucous and colon

carcinoma by means of messenger

RNA differential display. World Journal of Gastroenterology.

15(4): 26-27 (1999)

12. Wang, L., Lu, W., Chen, Y.G., et al, Establishment of the technique

of mRNAs differential display for human normal colon

mucous and colon cancer. Chinese Journal

of Experimental Surgery. 15(4): 306-307 (1998)

13. Wang, L., Lu, W., Chen, Y.G., Identification of differences between

normal and carcinomatous colorectal mucosa by mRNA differential

display. Acta Academiae Medicinae Shanghai. 25(6): 49 (1998)

14. Chen, Y.G., Lu, W., Lin, S.Y., The effect of endothelin on acute

gastric mucosa damage. Shanghai Medicine. 21(5): 261-263

(1997)

15. Chen, Y.G., Lu, W., Lin, S.Y., The effect of endothelin on gastric

mucosa Na/K ATPase

activity. Journal of Shanghai Medical University. 16:189-191

(1997)

16. Chen, Y.G., Lu, W., Lin, S.Y., The effect of Sodium nitroprusside on

endothelin-induced

gastric mucosa injury. Acta Academic Medicine Shanghai.19 (5):

266-268 (1996)

17. Wang, L., Chen, Y.G., Lu W., Preventive effect of CBS against acute

gastric mucosa injury in rats. Chinese J Gastroenterol.

1(2): 98-102 (1996)

18. Chen, Y.G., Lu, W., The effect of colloidal bismuth subcitrate on

ethanol induced gastric mucosa damage. Acta Academic

Medicine Shanghai. 22(supplement):125- 127 (1995)

Books

Lu, W., Chen, Y.G., Hematemesis and Hematochezia. Shanghai

Scientific and

Technological Publishing House. ISBN 7-5323-5179/R.1306 (Book

1999 in Chinese)

ABSTRACTS AND MEETING PRESENTATIONS

The 5th International Symposium on Intraoperative Neurophysiological

Monitoring (IONM)

(November 6-18, 2006, New York)

18th Annual Meeting (ASNM) (May 3-6, 2007, Chicago)

19th Annual Meeting (ASNM) (May 2-4, 2008, Chicago)

21th Annual Meeting (ASNM) (May 4-6, 2010, Vancouver)

23th Annual Meeting (ASNM) (May 5-7, 2012, Salt Lake City)

1. Chen, Y.G., Suriano, R., Liu, X.Y., Tadi, K., Ashok, B.T., Garikapaty,

V.P.S., Narayanan, R., and Tiwari, R.K. Genomic and proteomic

profiling of the molecular targets of a novel anti-prostate cancer

drug 1-nitroacridine. Proceedings of the American Association for

Cancer Research 45:264 (2004)

2. Tadi, K., Chen, Y.G., Ashok, B.T., Garikapaty, V.P.S., Banerjee, D.,

Wysocka-Skzrela, B., Konopa, J., and Tiwari, R.K. Capridine (C-1748):

A novel 1-nitroacridine derivative targets the cyclin dependent

kinase, cdk4, and the tumor suppressor gene, p16 in prostate cncer.

Proceedings of the American Association for Cancer Research 45:223

(2004)

3. Garikapaty, V.P.S., Ashok, B.T., Chen, Y.G., Mittelman, A., and

Tiwari, R.K. Anti-prostate cancer activity of Indole-3-carbinol (I3C)

and Diindolylmethane (DIM) is by inhibition of the Akt signal.

Proceedings of the American Association for Cancer Research 45:178

(2004)

4. Suriano, R., Ghosh, S.K., Chen, Y.G., Ashok, B.T., Banerjee, A., and

Tiwari, R.K. Glycosylation patterns associated with heat shock

protein, Gp96, contributes to its tissue specificity. Proceedings of

the American Association for Cancer Research 45:372 (2004)

5. Chen, Y.G., Ashok, B.T., Garikapaty, V.P.S., Banerjee, D., Konopa, J.,

Miller, D.G., Iotropoulos, M and Tiwari, R.K. Pre-clinical toxicology

and pathology of capridine, a novel anticancer agent in dogs.

Proceedings of the American Association for Cancer Research 44:372

(2003)

6. Narayanan, R., Tiwari, P., Wysocka-Skzrela, B., Konopa, J., Chen,

Y.G., Ashok, B.T. Mutagenicity of 1-nitro-9 hydroxyalkylamino acridine

derivatives using Ames test. Proceedings of the American Association

for Cancer Research 44:372 (2003)

7. Chen, Y.G., Ashok, B.T., Garikapaty, V.P.S., Liu, X.Y., Szostek, A.,

Wysocka-Skrzela,B., and Tiwari R.K. Pre-clinical studies of 1-

nitroacridine derivatives: Effective anti-tumor agents for prostate

cancer. Proceedings of the American Association for Cancer Research

43:77 (2002)

8. Chen, Y.G., Ashok, B.T., Garikapaty, V.P.S., Mittelman, A., and Tiwari

R.K. Cytokines mediated regulation of heat shock protein gp96.

Proceedings of the 17th Annual Scientific Meeting of the Society for

Biological Therapy, San Diego, CA, November 7-10. J. Immunother. 25

(6): S29 (2002)

9. Garikapaty, V.P.S., Ashok, B.T., Chen, Y.G., Lai, J., Mittelman, A.,

and Tiwari R.K. Anti-tumor activity of indole-3-carbinol in prostate

cancer. Proceedings of the American Association for Cancer Research

43:641 (2002)

10. Ashok, B.T., Chen, Y.G., Garikapaty, V.P.S., Mittelman, A., and Tiwari

R.K. Single chain antibodies (scFv) isolated from a phage display

library as a tool to identify unique gp96 associated peptide antigens.

Proceedings of the American Association for Cancer Research 43:969

(2002)

11. Ashok, B.T., Chen, Y.G., Mittelman, A. and Tiwari, R.K. synthetic

peptide mimotopes reacting to single chain antibodies (scFv) directed

against tumor rejection antigen gp96 as novel immunogens. Proceedings

of the American Association for Cancer Research 42:680-681 (2001)

12. Liu, X., Chen, Y.G., Ashok, B.T., Tschorn, J.,Roy, K.,Mittelman,A and

Tiwari R.K.

Modulation of gene expression by dietary factors in human breast

cancer. Proceedings of

the American Association for Cancer Research 42:655 (2001)

13. Chen, Y.G., Xinyan Liu, Abraham Mittelman, and Tiwari, R.K. Cytokine

mediated

regulation of the heat shock protein gp96. Proceedings of the

American Association for

Cancer Research 41:191 (2000)

14. Ashok, B.T., Chen, Y.G., Liu, X., Mittelman, A. and Tiwari, R.K.

Phyotantiestrogen: Cellular and molecular effects in breast cancer.

Proceedings of the American Association for Cancer Research 41:660

(2000)

15. Ashok, B.T., Chen, Y.G., Liu, X., Mittelman, A. and Tiwari, R.K.

Identification of prostate cancer associated immunogens using

synthetic combinatorial single chain (scFv) phage display antibody

library. Proceedings of the American Association for Cancer Research

41:698-699 (2000)

16. Chen, Y.G., Noronha, J., Yedavelli, S.P.K., Mittelman, A. and Tiwari,

R.K. The peptide chaperone gp96 is associated with HLA class I.

Proceedings of the American Association for Cancer Research 40:566.

(1999)

17. Ashok, B.T., Yedaveli, S.P.K., Chen, Y.G., Mittelman, A. and Tiwari,

R.K. Identification of novel tumor rejection antigenic epitopes using

synthetic single chain (scFv) combinatorial phage display antibody

library. Proceedings of the 4th World Congress on Advances in Oncology

and 2nd International Symposium on Molecular Medicine organized by the

International Journal of Oncology, Oncology Reports and International.

Journal of Molecular Medicine, Athens, Greece, October 7-9R (1999)

18. Chen, Y.G., Lu, W., Lin, S.Y., The effect of Omeprazole on endothelin-

induced gastric mucosa injury. Journal of Gastroenterology and

Hepatology. 10(supplement4): A168 (1995)

Reference: on demand

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