Department of Pharmaceutical Sciences

Xiaomei Bian Texas Southern University

Cell: 832-***-****

Email: acfd57@r.postjobfree.com

Address:***** ***** ***** ****** ** 78717

OBJECTIVE: Seeking a position in health care field

QUALIFICATION SUMMARY

Nano-scale drug formulation development

Itraconazole (synthetic triazole antifungal agent) nanosphere formulation for

intravenous administration sustained release using polymer:

This brand new formulation appears to be a promising injectable itraconazole

formulation for future clinical application.

Novel nanoconstruct of gold nanorods (GNR)/anti-carbonic anhydrase IX antibody

(CA IX) conjugates photothermal treatment of tumor without damage of normal

tissue:

This project recently was awarded NIH grant of $453,000.

Operation knowledge of analytical instrumentation

High pressure liquid chromatography (HPLC/UV):

Liquid chromatography-tandem mass spectrometry (LC/MS/MS):

UV-VIS spectrophotometer:

Zetasizer:

Analytical method development, validation of analytical methods

Outstanding written and verbal communication, multiple project management

Can work under dynamic, fast paced, collaborative environment with efficiency

EXPERIENCE

Research & teaching assistant Texas Southern University, Houston, TX, 2009 ~ 2014

Ph.D Thesis: Development novel nano medicine for drug delivery and cancer photothermal therapy

(Advisor: Dr. Huan Xie)

Developed itraconazole (ITZ)-loaded poly (lactic-co-glycolic acid) (PLGA) nanospheres

(PLGA-ITZ-NS) as a new sustained-release formulation for intravenous administration:

Desired PLGA-ITZ-NS around 200 nm was successfully developed by the

nanoprecipitation and evaporation methods, HPLC and LC-MS/MS method development

for assaying for ITZ in formulation and rat plasma, respectively. Pharmacokinetics study

showed optimal PLGA-ITZ-NS has a similar systemic bioequivalent to Sporanox while

providing a sustained plasma level.

Synthesized gold nanorods (GNRs), prepared and characterized stable GNRs/anti-carbonic

anhydrase IX (GNRs/anti-CA IX) conjugates for photothermal therapy in vitro and vivo study:

Successfully synthesized GNR with size of 30 x 10 nm, and characterized GNRs/anti-CA

IX conjugates; in vitro, binding efficacy of GNR/anti-CA IX to HT29 cells and

photothermal effect on HT29 cells; in vivo, establishing tumors in nude mice, Near

infra-red (NIR) laser photothermal ablation of tumor, which demonstrated great potential

of GNRs/anti-CA IX on localized photothermal treatment of tumor without damage of

normal tissue.

ChuZhou First People’s Hospital, China, 2002~2005

Anesthetist

3-year anesthetist residency experience in a first class general hospital. Working in a large scale

team and highly demanding environment.

SKILLS

Project communication

Written reports, journal articles, oral presentations, posters, multiple project management

Pharmaceutical nanotechnology formulation development

Lyoprotected nanospheres potential for intravenous administration of poorly soluble drugs;

multifunctional (GNR)-based nanoplatform for targeting photothermal therapy

Technical skills

HPLC, LC/MS/MS, ELISA, FreeZone Freeze-Dry Systme, Fluorescent microscopy, Western blotting,

Cancer cell culture, tumor inoculation in nude mice, Zetasizer, UV/Vis

Pharmacokinetic (PK) analysis

Compartment, non-compartment, oral or intravenous analysis

Software

Proficient in Microsoft Word, PowerPoint, Excel and Access; WinNonlin, SYSTAT, SigmaPlot, EndNote

AWARD

Oral presentation 3rd in research week (Awarded by Texas Southern University) 2012

TRAINING

2009

Nanospectra Biosciences, Inc,

Radiation Oncology Program from MD Anderson Cancer Center 2011

Completion of the Complete Cosmetic Chemist Training Program 2013

EDUCATION

Ph.D. Pharmaceutical Sciences Texas Southern University, Houston, TX 2014

B.S. Anesthesiology WanNan medical College, China 2002

PRESENTATION

Bian X, PEG-gold nanorods anti-CA IX conjugates for tumor targeting and therapy. 2012. Texas

Southern University Research Week, Apr, Houston, TX, USA.

Bian X, A A Deorukhkar; S Krishnan; Xie H. Gold nanorods-antibody conjugates for tumor

targeting and therapy. 2012. 13th RCMI International Symposium on Health Disparities, Dec. San

Juan, Puerto Rico.

Bian X, Liang S, Xie H. Development of injectable PLGA-itraconazole Nanospheres for Controlled

release. 2013 AAPS Annual Meeting and Exposition, Nov, San Antonio, TX, USA.

SELECTED PUBLICATIONS

Bian X, Liang S, John J, Hsiao C, Wei X, Liang D, Xie H. Development of PLGA-based

itraconazole injectable nanospheres for sustained release. International Journal of Nanomedicine,

2013:8 4521-4531.

Liang S, Bian X, Ma J, Arogunjo M, Deorukhkar AA, Krishnan S, Xie H, 2013. Development and

validation of a sensitive LC/MS/MS method for the determination of gamma-tocotrienol in rat

plasma: application to pharmacokinetic studies. Biomedical Chromatography, 2013 Jan; 27(1):58-66

Bian X, A A Deorukhkar; S Krishnan; Xie H. PEG-gold nanorods anti-CA IX conjugates for tumor

targeting and photothermal therapy. (Ready to submit)

REFERENCE AVAILABEL UPON REQUEST

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