arto d. krikorian, M.Sc. http://www.linkedin.com/pub/arto-

krikorian/85/64/215

**-** ** ******

Astoria, NY 11105 acfc60@r.postjobfree.com

Cell: 646-***-****

OBJECTIVE

OBJECTIVE

Seeking a challenging opportunity where my synthetic/analytical/problem

solving skills and abilities can be fully utilized to contribute and foster

the growth & prosperity of the company. Open to apply my highly analytical

skills and scientific background in different domains. Willing to work at

the level of a B.Sc. chemist with efforts to branch out into related areas.

SUMMARY

. M.Sc. level Research Chemist with over 6 years of industrial laboratory

experience.

. In-depth experience with Analytical Laboratory method development and

techniques.

. Thorough familiarity in purification and characterization of organic

compounds (HPLC/UPLC/MPLC including chiral media, mass directed HPLC

purification, LC-MS, FTIR, MS, UV, crystallization, flash chromatography,

preparative TLC, NMR 1-D/2-D).

. Co-inventor of five U.S. patents and applications; member of the American

Chemical Society

. Extensive experiences with multi-step organic synthesis from milligrams

to hundred grams scale using a wide range of modern synthetic methods.

. Experience designing medicinal chemistry target molecules with

understanding of the program SARs and biological data interpretation.

. Experienced in Natural products and Biologically active compounds

synthesis.

. Impact on early and late stage projects including different therapeutic

areas such as: Atherosclerosis/Cardiovascular, Diabetes/Obesity,

Respiratory/Immunology.

. Effective team player willing to compromise for the good of the team.

. Ability to multitask, manage, balance and prioritize work, strong

organizational skills with attention to detail.

. Proficient in chemical database programs, literature searches, MS Word,

Excel, PowerPoint, ChemDraw, ISIS/Draw and the internet.

PROFESSIONAL EXPERIENCE

mErck research laboratories, Rahway, NJ 2007 - 2013

Research Chemist / Scientist - Discovery Chemistry

. Worked on a cross-site team involving design, multi-step synthesis, scale-

up, extraction, isolation, purification and characterization of small

molecules as development candidate for the drug discovery programs.

. Active collaboration along with target design/synthesis led to the

discovery of several lead compounds tested in pre-PCC assays including

safety animal models.

osi pharmaceuticals, inc., Farmingdale, NY 2006 - 2007

Senior Research Associate - Cancer Chemistry

. Member of the High Throughput Synthesis group focusing on early space

leads and target validation along with synthesis, isolation and

characterization of small molecules for in vitro / in vivo studies.

department of chemistry,

university of new brunswick, New Brunswick, Canada 2001 - 2005

Research Associate (2005)

Graduate Research Assistant (2001 - 2004)

Project directed towards the total synthesis of biologically active

Manzamine analogs.

Graduate Teaching Assistant (2001 - 2004)

Teaching assistant for chemical engineering, general and organic chemistry

undergraduate laboratory courses. Supervision of summer students (2002,

2003).

institute of organic chemistry

Bulgarian academy of sciences, Sofia, Bulgaria 1999

Research Chemist

Natural products synthesis involving extraction, isolation, purification

and identification of biologically active products.

EDUCATION

M.Sc., Organic Chemistry, 2004

University of New Brunswick, Department of Chemistry, Fredericton, Canada

Thesis: "Synthetic Studies Towards the Manzamine Alkaloids"

Advisor: Professor David I. MaGee

The manzamine alkaloids are complex polycyclic marine-derived natural

products which exhibit a diverse range of bioactivities including

cytotoxicity, anti-tuberculosis, anti-malarial and anti-insecticidal

activities. An asymmetric synthesis of an advanced intermediate was

achieved in 21 steps with very good overall yield and stereoselectivity.

B.Sc., Chemistry & Physics

Sofia University, Department of Chemistry, Sofia, Bulgaria, 1998

research skills

Hands on experience with multi-step organic synthesis using a wide range of

modern synthetic methods.

. Involved in:

- Catalytic Asymmetric Synthesis.

- Stereoselective Hydrogenation.

- Organometallic Chemistry.

- Heterocyclic Chemistry.

- Parallel Synthesis&High Speed Analoging (HSA).

- Medicinal Chemistry.

- Scale-up of synthetic intermediates and final compounds.

- Ability to utilize SAR interpretations for designing novel molecules.

. In-depth experience with Analytical Laboratory techniques:

- HPLC/MPLC purification.

- TLC analysis&preparative TLC.

- LC-MS analysis.

- Flash Chromatography.

- NMR (1-D, 2- D).

- FTIR, MS, UV, optical rotation.

publications

Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-

cyclohexanecarboxylic Acid Moiety

Shuwen He, Qingmei Hong, Ravi P. Nargund, Zhicai Wu, Arto D. Krikorian,

Jeffrey T. Kuethe, Robert J. DeVita, Jian Liu, Deodial Guiadeen, Shirly, Pinto et al.

Discovery and Preclinical Sciences, Merck Research Laboratories, 2000

Galloping Hill Road, Kenilworth, New Jersey 07033, United States

ACS Med. Chem. Lett., 2013, 4 (8), pp 773-778

patents

Preparation of novel benzimidazole derivatives as DGAT-1 inhibitors

By Krikorian, Arto D.;Devita, Robert J.; Yu, Yang; Liu, Jian; He, Shuwen;

Miller, Daniel J.; Wu, Zhicai; Yang, Ginger; Xu-Qiang; Hong, Quingmei; Lai,

Zhong; et al

PTC Int. Appl. (2013), WO 201-***-**** A2 20130906

Preparation of triazolylpyridine derivatives and analogs for use as DGAT-1

inhibitors

By Devita, Robert J.; He Shuwen; Liu, Jian; Krikorian, Arto D.; Cernak,

Timothy A.; Yang, Ginger Xu-Qiang; Wu, Zhicai; Yu, Yang; Shen, Dong-Ming;

Lai, Zhong; et al

PTC Int. Appl. (2013), WO 201-***-**** A1 20130627

Preparation of imidazole derivatives as DGAT-1 inhibitors

By Liu, Jian; Balkovec, James M.; Krikorian, Arto D.; Miller, Daniel J.;

Guiadeen, Deodial; Yang, Ginger Xu-Qiang; Jian, Tianying; Wu, Zhicai; Yu,

Yang; Nargund, Ravi P.; et al

PTC Int. Appl. (2013), WO 201-***-**** A1 20130523

Preparation of imidazopyridinylphenylpyridinylpiperidinylacetic acid

derivatives and analogs for use as DGAT-1 inhibitors

By Liu, Jian; Balkovec, James M.; Krikorian, Arto D.; Guiadeen, Deodial;

Yang, Ginger; Jian, Tianying; Wu, Zhicai; Yu, Yang; Nargung, Ravi P.;

Vachal, Petr; et al

PTC Int. Appl. (2012), WO 201-***-**** A1 20120719

Preparation of imidazole derivatives as DGAT-1 inhibitors

By Liu, Jian; Balkovec, James M.; Krikorian, Arto D.; Guiadeen, Deodial;

Yang, Ginger; Jian, Tianying; Wu, Zhicai; Yu, Yang; Nargung, Ravi P.;

Vachal, Petr; et al

PTC Int. Appl. (2012), WO 201-***-**** A2 20120405

poster presentations

Krikorian A.D., MaGee D. I. "Synthetic Studies on the Manzamine Alkaloids."

- presented at the IUPAC Conference, Ottawa, August, 2003

REFERENCES

Jian Liu, Ph.D.

Principal Scientist,

RY Discovery Chemistry,

Merck Research Laboratories, Rahway, NJ

732-***-****

acfc60@r.postjobfree.com

Jeff Hale, Ph.D.

Associate Vice President,

RY Discovery Chemistry,

Merck Research Laboratories, Rahway, NJ

acfc60@r.postjobfree.com

Deodial Guiadeen

Sr. Scientist,

RY Discovery Chemistry,

Merck Research Laboratories, Rahway, NJ

acfc60@r.postjobfree.com

Dr. David MaGee

Professor of Chemistry,

University of New Brunswick,

Department of Chemistry

506-***-****

acfc60@r.postjobfree.com

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