Cynthia Zizola, PhD

Expert in Cellular Biology, Molecular Biology, Biochemistry.

733W 183 Street, Apt 3G, New York, NY 10033

Phone: 347-***-**** home: 212-***-****.

E-mail: aceo3h@r.postjobfree.com

Objective: to obtain a challenging technical, managerial or scientific writer position in a

prestigious company.

Work Experience

Columbia University in the City of New York

Associate Research Scientist 2003-

2013

My research work in several laboratories in Columbia University was focused on

the study of PPAR in the metabolism of lipids and glucose, applied to nutrition and

cardiology:

• Demonstrated that the pharmacological enhancement of the activity of PPAR

delta partially reverts the skeletal muscle dysfunction and intolerance to exercise

in advanced stages of heart failure. Responsible for two projects at the same

time.

• Investigated the role of Retinol Binding Protein Receptors (CRBPs) in lipid and

glucose metabolism. Characterized the CRBP-III gene promoter and its

regulation by PPAR. Discovered that CRBP-I regulates adipogenesis and the

accumulation of lipid in adipose tissue. Responsible for two projects at the same

time.

• Developed laboratory methods. Designed experiments.

• Provided laboratory training to several students of Masters in Nutrition Program.

• Worked in collaboration with intra e inter laboratory colleagues.

• Collaborated on the evaluation of peer’s articles prior to publication in Scientific

Journals.

• Performed a high amount of laboratory administrative tasks.

During my first year in Columbia University, I was trained in Molecular Biology:

• Performed more than 200 Southern blots for the analysis of generation of

genetically modified animals.

• Performed DNA transfection in several hundreds of embryonic cells.

• Developed new mutated DNA constructs, in order to create transgenic animals.

IBYME-CONICET, Buenos Aires, Argentina

PhD CONICET (functions as NIH in Argentina) fellow. 1996-

2002

• Responsible for a Research Project that led to the publication of two articles in

Scientific Journals and one Doctoral Thesis in Biochemistry. Described the

composition and role of the extracellular matrix during adipogenesis.

Education

School of Pharmacy and Biochemistry, UBA, Argentina

• PhD in Biochemistry; Field, Cellular Biology. 1996-

2002

• Master’s degree in Biochemistry. GPA 3.22 1990-

1995

Teaching experience

CAECE University, Buenos Aires, Argentina

2002

Lecturer, Biochemistry, School of Biology.

School of Pharmacy and Biochemistry, UBA, Argentina

1992-1997

Instructor, Physicochemistry.

Relevant Skills

• Large experience in Molecular Biology: RT-PCR, cloning, mutagenesis, gene silencing

using RNAi, preparation of viral stock, cell infection, transcriptional activity assays, CHIP,

genotyping, western blotting.

• Extensive knowledge and experience in cell culture and in vitro differentiation of adipose

and muscle lineage.

• Experience in HPLC, DNA sequencing, ELISA, fluorescence microscopy, cellular

enzymatic activity and luminescence assays in 96 well plates, immunohistology, RIA.

• Ability to present data in departmental seminars and conferences. Knowledge of

data analysis

• Proficient in English language in writing scientific articles, abstracts and oral

presentations of Projects.

• Proficiency in basic computer and software applications. Word, Excel, PowerPoint, Prism.

• Proficient in Spanish language. Professional in Science and Medical Spanish

terminology.

Publications and Presentations

• Metabolic and structural impairment of skeletal muscle in heart failure.

Zizola CF, Schulze PC. Heart Fail Rev. 2012 Oct 12.

• American Heart Association Scientific Session. November 3-7 2012 Los

Angeles, California. “Activation of PPAR Delta Signaling Corrects Impaired

Skeletal Muscle Oxidative Metabolism in Heart Failure ”. Zizola CF, Paul

Christian Schulze, Columbia University, New York, NY.

• Cellular retinol-binding protein type I (CRBP-I) regulates adipogenesis.

Zizola CF, Frey SK, Jitngarmkusol S, Kadereit B, Yan N, Vogel S. Mol Cell Biol.

2010 Jul;30(14):3412-20.

• Cellular retinol-binding protein type III is a PPARgamma target gene and

plays a role in lipid metabolism. Zizola CF, Schwartz GJ, Vogel S. Am J

Physiol Endocrinol Metab. 2008 Dec;295(6):E1358-68.

• Chronic ethanol consumption increases cardiomyocyte fatty acid uptake and

decreases ventricular contractile function in C57BL/6J mice. Hu C, Ge F, Hyodo E,

Arai K, Iwata S, Lobdell H 4th, Walewski JL, Zhou S, Clugston RD, Jiang H, Zizola CF,

Bharadwaj KG, Blaner WS, Homma S, Schulze PC, Goldberg IJ, Berk PD. J Mol Cell

Cardiol. 2013 Feb 16;59C:30-40

• Role of versican and hyaluronan in the differentiation of 3T3-L1 cells into

preadipocytes and mature adipocytes.Zizola CF, Julianelli V, Bertolesi G,

Yanagishita M, Calvo JC. Matrix Biol. 2007 Jul;26(6):419-30.

• Changes in IGF-I receptor and IGF-I mRNA during differentiation of 3T3-L1

preadipocytes. Zizola CF, Balañá ME, Sandoval M, Calvo JC. Biochimie. 2002

Oct;84(10):975-80.

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