H ICHAM NAIMY

** ********* ****** *** * • BOSTON, MA 02116 • PHONE 857-***-****• acemtg@r.postjobfree.com

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EDUCATION

2005–2011 Boston University, Boston, MA

Ph.D. in biochemistry (GPA 3.92)

2003-2005 New York University, New York, NY

MS in Biology (GPA 4.0)

E XPERIENCE

2011-Present, Shire Pharmaceuticals, Lexington, MA

S enior S cientist J anuary 2014- Present

S cientist 2011-December 2013

Department of non-clinical and bioanalytical/biomarker development

Developed a liquid chromatography/Mass spectrometry (LC/MS) based assay to analyze glycosaminoglycans that represent

the key pharmacodynamic efficacy biomarkers for various mucopolysaccharidosis clinical programs.

Guided the transfer of technology developed in-house to CROs and managed the validation process according to

regulatory agencies guidelines.

Represented my department in the clinical trial team meetings.

Interpreted data generated from clinical sample analysis.

Collaborated on various projects with different departments involved in the drug development pipeline from discovery

research to preclinical and clinical development.

Designed experiments, wrote protocols and reports.

Authored a manuscript for publication (in progress).

Presented findings in seminars and conferences.

Excellent technical writing, communication and presentation skills.

2005–2011, Boston University School of Medicine, Boston, MA

Graduate research assistant

Department of Biochemistry

Studied the structure-function relationship of cell-surface heparan sulfate co-receptors in order to elucidate the mechanisms

by which they regulate growth factors signaling.

Wrote peer-reviewed articles for publication in scientific journals.

Prepared slides and posters to present data in scientific conferences.

2004– 2005, New York University, New York, NY

R esearch Assistant

Assisted in the identification of a novel transcription factor involved in early embryonic patterning of Drosophila

melanogaster using a yeast two hybrid assay.

Mastered molecular biology techniques such as cloning, expressing recombinant proteins in E.coli, nucleic acid separation by

gel electrophoresis, western blots and DNA mobility shift assay.

2004–2005, New York University, New York, NY

T eaching Assistant

Conducted weekly laboratory lectures and designed experiments for the Evolutionary Biology course.

PUBLICATIONS

The non-reducing end of heparan sulfate binds fibroblast growth factor-2 (FGF2) with high affinity and promotes its

signaling.

Hicham Naimy, Jo Ann Buczek-Thomas, Matthew A. Nugent, Nancy Leymarie and Joseph Zaia.

The journal of biological chemistry. 2011 June 3;286(22):19311-9

Screening for anticoagulant heparan sulfate octasaccharides and fine structure characterization using tandem mass

spectrometry.

Hicham Naimy, Nancy Leymarie, and Joseph Zaia

Biochemistry. 2010 May 4;49(17):3743-52.

Improved hydrophilic interaction chromatography LC/MS of heparinoids using a chip with postcolumn makeup

flow.

Staples GO, Naimy H, Yin H, Kileen K, Kraiczek K, Costello CE, Zaia J.

Analytical Chemistry. 2010 Jan 15;82(2):516-22.

A chip-based amide-HILIC LC/MS platform for glycosaminoglycan glycomics profiling.

Staples GO, Bowman MJ, Costello CE, Hitchcock AM, Lau JM, Leymarie N, Miller C, Naimy H, Shi X, Zaia J.

Proteomics. 2009 Feb;9(3):686-95.

Characterization of Heparin Oligosaccharides Binding Specifically to Antithrombin III Using Mass Spectrometry.

Hicham Naimy, Nancy Leymarie, Michael J. Bowman, and Joseph Zaia

Biochemistry. 2008 Mar 11;47(10):3155-61

CONFERENCE AND POSTERS

The Gordon proteoglycans conference, 2013

The non-reducing end of heparan sulfate binds fibroblast growth factor 2 with high affinity and activates its

signaling. 2011

Hicham Naimy, Nancy Leymarie and Joseph Zaia.

Glycobiology Conference.

Characterization of heparan sulfate N -sulfated domains binding fibroblast growth factor-2. 2010

Hicham Naimy, Nancy Leymarie and Joseph Zaia.

Proteoglycan Gordon conference

Tandem mass spectrometry for characterization of protein binding heparan sulfate octasaccharides. 2009

Hicham Naimy, Nancy Leymarie and Joseph Zaia.

American society for Mass spectrometry Conference

AWARDS

Shire excellence award, 2013

Glycobiology conference student award, 2010

Myrna and Carl Franzblau student travel award, 2009

MEMBERSHIPS

American medical writers association

American Society for Mass Spectrometry

Society for Glycobiology

Member of the Biochemistry program admission committee

LANGUAGES

Fluent in spoken and written, English, French and Arabic

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