Bao Q. Vuong, PhD

*** *. **** **. #**, New York, NY 10024

212-***-**** • aceeic@r.postjobfree.com

US Citizen

Objective

I am seeking opportunities to utilize my doctoral and postdoctoral training in molecular

immunology and undergraduate education in chemical engineering to discover and create unique

solutions to human diseases.

Education

2004 PhD, Columbia University, Department of Microbiology

1999 MPhil, Columbia University, Department of Microbiology

1998 MA, Columbia University, Department of Microbiology

1995 BS, Cornell University, School of Chemical and Biomolecular Engineering

Research & Professional Experience

2006-Present Post-doctoral Fellow, Memorial Sloan-Kettering Cancer Center,

Jayanta Chaudhuri laboratory

2004-2005 Scientific Associate, Ogilvy Healthworld

1997-2004 Graduate Student, Columbia University, Thesis advisor: Paul Rothman

1996-1997 Research Technician, Cornell University, Steve Ealick laboratory

1995-1996 Research Technician, Cornell University, Jane Gibson laboratory

1992-1995 Research Technician, Cornell University, Volker Vogt laboratory

Scientific & Technical Skills

Laboratory – flow cytometry, immunofluorescence, confocal and phase contrast microscopy,

mammalian cell purification and culture, ES cell culture, protein purification (Akta FPLC),

immunoblotting, ELISA, blotting (Southern, northern), sucrose gradient fractionation, ChIP,

EMSA, cloning, gene transfer and targeting, qPCR, DNA/RNA purification and expression

analysis, retroviral/lentiviral gene transduction

Computer software – Microsoft Office, Endnote, Adobe Photoshop, Adobe Acrobat, Prism

Bioinformatics software – DNAstar, Ingenuity

Other Activities

Professional memberships – New York Academy of Sciences, American Association for the

Advancement of Science

Alumni and volunteer activities – Cornell Externship Advisor, Cornell Alumni Admissions

Ambassador Network, New York Cares, Top Honors (2010-11 Tutor of the Year)

Hobbies – Running (2011 NYC marathon, 2013 Marine Corps Marathon), Camping, Hiking,

Skiing, Photography

Publications

1. Simin Zheng, Bao Q. Vuong, Bharat Vaidyanathan, Jia-Yu Lin, Feng-Ting Huang, and

Jayanta Chaudhuri. RNA-mediated targeting of AID to DNA during class switch

recombination. Manuscript under review at Nature.

2. James A. Dowdle, Monika Mehta, Elizabeth M. Kass, Bao Q. Vuong, Akiko Inagaki, Dieter

Egli, Maria Jasin, and Scott Keeney. Mouse BAZ1A (ACF1) is dispensable for double-

strand break repair but is essential for averting improper gene expression during

spermatogenesis. PLoS Genet. 2013 Nov;9(11):e1003945.

3. Bao Q. Vuong, Kayleigh Herrick-Reynolds, Bharat Vaidyanathan, Joseph Pucella, Anna J.

Ucher, Nina Donghia, Xiwen Gu, Laura Nicolas, Urszula Nowak, Numa Rahman, Matthew

P. Strout, Kevin Mills, Janet Stavnezer, and Jayanta Chaudhuri. A DNA break- and

phosphorylation-dependent positive feedback loop promotes immunoglobulin class switch

recombination. Nat Immunol. 2013 Nov;14(11):1183–9.

(News and Views, “You break it, you fix it: functions for AID downstream of

deamination”, Nat Immunol. 2013 Nov;14(11):1112–4)

4. Bao Q. Vuong and Jayanta Chaudhuri. Combinatorial Mechanisms Regulating AID-

Dependent DNA deamination: Interacting Proteins and Post-translational Modifications.

Semin Immunol. 2012 Aug;24(4):264-72.

5. Bao Q. Vuong, Mieun Lee, Shaheen Kabir, Cristina Irimia, Stephania Macchiarulo, G.

Stanley McKnight, and Jayanta Chaudhuri. Specific recruitment of protein kinase A to the

immunoglobulin locus regulates class-switch recombination. Nat Immunol. 2009

Apr;10(4):420-6.

(News and Views, “AID and RPA: PKA makes the connection local”, Nat Immunol. 2009

Apr;10(4):367-9)

6. Hwei-Ling Cheng , Bao Q. Vuong , Uttiya Basu , Andrew Franklin, Bjoern Schwer, Jillian

Astarita, Ryan T. Phan, Abhishek Datta, John Manis, Frederick W. Alt, and Jayanta

Chaudhuri. Integrity of the AID serine-38 phosphorylation site is critical for class switch

recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A. 2009 Feb

24;106(8):2717-22. ( Equal contribution)

7. Jayanta Chaudhuri, Uttiya Basu, Ali Zarrin, Catherine Yan, Sonia Franco, Thomas Perlot,

Bao Vuong, Jing Wang, Ryan T. Phan, Abhishek Datta, John Manis, and Frederick W. Alt.

Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism.

Adv Immunology. 2007;94:157-214.

8. Bao Q. Vuong, Lisa McKeag, Julie A. Losman, Jianze Le, Alexander S. Banks, Scott Fay,

Peter Chen, and Paul Rothman. Regulation of Cytokine Signaling. Cell Signaling in

Vascular Inflammation. Ed. Jahar Bhattacharya. Humana Press, 2005.

9. Bao Q. Vuong, Teresita Arenzana, Brian M. Showalter, Julie A. Losman, X. Peter Chen,

Justin Mostecki, Alexander S. Banks, Andre Limnander, Neil Fernandez, and Paul B.

Rothman. SOCS-1 localizes to the Microtubule Organizing Complex-associated 20S

proteasome. Mol Cell Biol. 2004 Oct; 24(20):9092-101.

10. Julie A. Losman, X. Peter Chen, Bao Q. Vuong, Scott Fay, and Paul B. Rothman. PP2A

regulates the stability of Pim protein kinases. J Biol Chem. 2003 Feb 14; 278(7):4800-5.

11. Feng Cong, Jean Tang, Byung J. Hwang, Bao Q. Vuong, Gilbert Chu, and Stephen P. Goff.

Interaction between UV-DDB proteins and the c-Abl tyrosine kinase. J Biol Chem. 2002

Sept 20; 277(38):34870-8.

12. X. Peter Chen, Julie A. Losman, Simone Cowan, Elizabeth Donahue, Scott Fay, Bao Q.

Vuong, Martijn C. Nawijn, Danielle Capece, Victoria L. Cohan, and Paul Rothman. Pim

serine/threonine kinases regulate the stability of Socs-1 protein. Proc Natl Acad Sci U S A.

2002 Feb 19; 99(4):2175-80.

13. Hong Jiang, Kristina Foltenyi, Masaki Kashiwada, Liz Donahue, Bao Vuong, Boyd Hehn,

and Paul Rothman. Fes mediates the IL-4 activation of insulin receptor substrate-2 and

cellular proliferation. J Immunol. 2001 Feb 15; 166(4):2627-34.

14. Min Zhou, Matthew J. Pugmire, Bao Q. Vuong, and Steven E. Ealick. Cloning, Expression

and Crystallization of Pyrimidine Nucleoside Phosphorylase from Bacillus

Stearothermophilus. Acta Crystallographica. Section D, Biological Crystallography Jan

1999; 55(Pt 1):287-90.

15. Ladislau C. Kovari, Cory A. Momany, Faith Miyagi, Sukyeong Lee, Stephen Campbell, Bao

Vuong, Volker M. Vogt, and Michael G. Rossman. Crystals of Rous Sarcoma Virus Capsid

Protein Show a Helical Arrangement of Protein Subunits. Virology 1997 Nov 10; 238(1):79-

84.

Contact this candidate