Mahesh M. Bhide Ph.D.

Contact: Email: acealj@r.postjobfree.com

Residence: 29, Electric Avenue, East Greenbush, NY-12061, Phone: 330-***-****

(Home), 518-***-****(Cell)

Objective:

I am a result oriented formulation expert having extensive experience in formulation

development, project management and manufacturing with a strong knowledge of

Topical drug delivery (Cream, ointment and Gels), Transdermal drug delivery, solid

oral and Nano/micro particle based drug delivery, looking for a suitable industrial

position in formulation R and D or Manufacturing.

Expertise:

Topical drug delivery (Ointment, Gels and creams),

Emulsion formulation

Excipient screening

Modified drug delivery systems (Nanoparticles, Microparticles, Liposomes)

Polymeric drug delivery

Spray drying

cGMP Manufacturing

Well familiar with CFR-Title 21, CFR part 210, CFR part211, ICH and FDA guidelines

Patent search

Analytical instruments (Hands on):

UV, DSC, IR, NMR, Particle size analyzer, Optical microscope, Polarized microscope,

Confocal microscope, Hot stage microscope, Gel electrophoresis, Flow cytometer

Limited hands on with: HPLC, RTPCR

Industrial Experience:

Principal Scientist @ Eurofins Lancaster labs:

1.

02/2013 to 02/2014

• Worked hands on early development topical dosage (Semisolid) forms

(Cream, gel and ointments)

• Worked on API-excipient compatibility, solubility and process parameters

• Worked on development of proof of concept

• Worked on candidate selection documents

• Designed, validated and implemented formulation related experiments

and procedures

• Carried out pre-formulation and formulation development studies

• Hands on with Hot-Stage microscopy and PLM

• Working knowledge of type II and IV dissolution apparatus

• Developed and managed project plans for early development

formulations

• Provided support to the client on technical needs

• Maintained positive communication with cross functional groups such as

analytical, skin biology and marketing

• Presenting the data during departmental meetings

• Well aware of ICH and FDA guidelines

• Well aware of DOE approach

Deputy Manager (Formulation Technology) @ Dr. Reddy’s Laboratories Ltd.,

2.

Hyderabad, India (10/2010 – 05/2011)

Literature and Patent Search to develop Platform Technologies.

•

Design a patent non infringing routes for Developing novel Drug

•

Delivery Systems,

Collaborated with the internal team for scale up

•

Worked on depot injection (Suspension formulation)

•

Hands on experience with the particle size reduction

•

(Nanosizing)using bead mills

In depth knowledge of GMP/GLP procedures

•

Deputy Manager (Novel Drug Delivery Systems) @ Bio Plus Pvt. Ltd, India

3.

(10/2008- 02/2010)

Developed Novel drug delivery systems (Using Dendrimers and PLGA

•

polymers)

Planed, validated and executed the formulation strategies

•

Carried out pre-formulation and formulation studies

•

Worked on modified release solid oral dosage (Using enteric coating

•

polymers)

Hands on experience with wurster coating, Wet and dry granulation

•

and tablet compression

Carried out content uniformity, hardness and Friability testing

•

Hands on experience with spray drying

•

R @D Chemist/Production supervisor @ Johnson and Johnson India (Ltd) (1997-

4.

2001)

•Worked on transdermal drug in adhesive formulations

•Selection of backing material, release linear and compatible adhesives

•Film coating on backing material

•Analysis of content uniformity and release profile

Worked in cGMP transdermal formulation Manufacturing facility

•

Maintained the plant equipments

•

Planned and coordinated with other departments, executing daily,

•

monthly production targets in process manufacturing plant

Prepared the Batch records

•

Coordinated with internal and external auditing agencies

•

Other responsibilities include troubleshooting,

•

directing/motivating/training team of 25 shift personnel

Education Details:

Ph.D.: Chemistry

The University of Akron, Ohio, USA (08/2001 to 05/2006)

Research Project: “Formulation of polymeric Transdermal system for

Nitric Oxide Delivery.”

Transdermal system was formulated encapsulating an API in electrospun

nanofibers

Project was sponsored by Johnson and Johnson, UK and Ethicon USA

Successfully developed and tech. transferred sponsor’s site.

Masters in Science (Organic Chemistry) from Mumbai University

•

(05/1993 to 05/1995)

Patent: Debridement method using Nitric Oxide donor devices and compositions

(US 201********)

Research Experience

Post Doc Fellow : University of Rochester Medical Center, Rochester, USA (10/2006 –

•

10/2007), worked on following Research Project:

Research Project: drug delivery to liver macrophages using

biodegradable microparticles

Synthesized biodegradable polymers like polyketal polymer

•

Proficient with drug delivery techniques like micro and nano particle

•

encapsulated formulations using polyketal and PLGA polymers

Proficient in liposome preparation and encapsulation of active reagents

•

Extensively worked on anti cancer agent and gene delivery using

•

microparticles

Hands on in vivo dose response studies with rodents

•

Hands on knowledge of flow cytometry

•

Adjunct Instructor (Organic Chemistry, Adjunct): College of Saint Rose

(Albany, NY 08/2011 – 01/2013)

Organic Chemistry and lab courses

Advanced Organic Chemistry course: A special course

Adjunct Instructor (Pharmaceutics): Albany college of Pharmacy (Albany,

NY 08/2011-01/2013)

Taught Pharmaceutics I and II (M.Pharm and Pharm D. students)

•

(M.Pharm class strength: 7-8 students. Pharm D class strength:

200)

Taught Polymers in pharmaceutics as a special topic to M.Pharm students

•

Set exams

•

Graded exam

•

Advice students

•

Used interactive tools such as Blackboard for uploading notes, homework

•

and grades

Publications and Presentations:

Poster Presentation: PETIM Dendrimer as a novel drug delivery carrier, at

•

Nanotech India 2009 conference, Kochi, India

• Poly Propyl Ether Imine (PETIM) dendrimer: A novel non-toxic dendrimer

for sustained drug delivery, The European Journal of medicinal Chemistry

• Double blind, randomized, placebo controlled clinical trial for the

treatment of diabetic foot Ulcers, using nitric oxide releasing patch:

PATHON, Sandra Y Silva, Ligia C Rueda, Gustavo A Márquez, Marcos López,

Daniel J Smith, Carlos A Calderón, Juan C Castillo, Jaime Matute, Christian F

Rueda-Clausen, Arturo Orduz, Federico A Silva, Piyaporn Kampeerapappun,

Mahesh Bhide, Patricio López-Jaramillo, Trials 2007, 8:26

Polyketal copolymer: A new acid sensitive delivery system for treating

•

acute liver failure,

Stephen C.Yang, Mahesh Bhide, Nick Crispe, Robert Pierce, Niren Murthy,

Bioconjugate Chem, 19(6): 1164-9

Controlled release of nitric oxide from electrospun nanofibers transdermal

•

matrices. Abstracts, 35th Great Lakes Regional Meeting, ACS, Chicago, IL

Electro-spun Polyethylenimine diazeniumdiolates for the controlled delivery

•

of nitric oxide. Abstracts of Papers, 229th ACS National Meeting, San Diego,

CA

Achievements & Awards

Honored by including in Inventors wall of fame at The University of Akron,

•

OH

On Editorial board of Journal of Pharmaceutical investigation

•

Published a book (ISBN-NR: 978-3-639-19603-0)

•

Others

Professional References are available on request

Contact this candidate