Jing

Zhu,

Ph.D.

3255

Normandy

Woods

Dr.

#D

acdogg@r.postjobfree.com

Ellicott

city,

MD

21043

Phone

(cell):

513

532

9788

Objective

A research and development position using my expertise in Medicinal chemistry, Biotechnology and

specialty in Neuroscience.

EMPLOYMENT

Research Fellow

The Johns Hopkins University Baltimore, Maryland, USA 08/2008–present

EDUCATION

Ph.D. Chemistry (GPA: 3.9/4.0)

University of Cincinnati – Cincinnati, Ohio, USA 09/2004–06/2008

DISSERTATION: Host-rotaxanes as Binding Agents: The Effects of Wheel Dynamics

B.S. Chemistry (GPA: 3.2/4.0)

The Nanjing Normal University– Nanjing, China 09/1995–07/1999

QUALIFICATIONS AND SKILLS

Ten years of research experience in medicinal chemistry, biochemistry, biology and

neuroscience.

Strong ability to lead and work with cross-functional teams and productive in research.

Created many different types of novel chemical molecules for biological systems, including

neuronprotective drugs, drug delivery reagents and protein mimics and validated their function in

different biochemistry and biology assays.

Led a small molecule drug discovery project. Designed, developed and optimized diverse cell-

based and biochemical primary and secondary assays for early-stage drug discovery.

Skilled in purification and characterization of compounds including peptides, and

fuorescenated dyes using TLC, HPLC, FT-IR, UV/VIS and GC-MS, NMR.

Broad experience in biochemistry and biology techniques and assays: siRNA transfection;

various nucleic acids (DNA, RNA, etc) isolation and characterization; protein purification

and identification; gel electrophoresis including SDS-PAGE, silver and colloidal blue staining

and Imaging. HTS assay; in vitro efficacy and in vivo efficacy; ATP assay; polymerase chain reaction

(PCR); real time PCR; DRG primary culture; cell culture; protein binding target; ECL western blotting;

gene knockdown; design of primers.

Extensive experience in research instruments: Gas Chromatography mass spectroscopy

(GC-MS),High Performance Liquid Chromatography (HPLC), UV/Visible and Fluorescent

Spectrophotometry, 1D/2D NMR, IR, Microscopy, Luminometer, Peltier Thermal Cycler(PTC), RT-

PCR, SmartSpecTM Plus spectrophotometer, nanodrop and Imaging .

Experienced in scientific writing and effective presentation; able to understand, learn and

utilize new knowledge and techniques promptly; comfortable working with a variety of people from

many diverse backgrounds.

Outstanding skills at learning, analyzing and solving problems independently; self-motivated,

well-organized and multitasking; able to be both a team leader and a team player.

Excellent computer skills: proficient with computational softerware as Hyperchem and Gaussian,

analytical and plotting software as Softmax Pro, Openlab, Quantity One, Scaffold 3, MestreNova

and Graphpad Prism and other work related programs.

ACHIEVEMENTS, AWARDS AND PROFESSIONAL AFFILIATIONS

7 publications in prestigious international journals including Annals of Neurology, JOC, BMCL,

Org. Biomol. Chem., J. of PNS.

3 patent under review, 1 paper is preparing.

10 presentations at international conferences including ACS national meetings, meeting of the

Peripheral Nerve Society, Drug Discovery meeting, JHU Neuroscience meeting.

National Travel Award on 2011 PNS meeting and one publication was awarded the hottest

paper of 2007

Award of Training in Neurotherapeutics discovery and development for academic

scientists.(2013)

Jing

Zhu,

Ph.D.

3255

Normandy

Woods

Dr.

#D

acdogg@r.postjobfree.com

Ellicott

city,

MD

21043

Phone

(cell):

513

532

9788

Recipient of the University Graduate Scholarship, Research Assistantship supported by NSF and

Teaching Assistantship from the University of Cincinnati, 2004 to 2008.

High School Chemistry Teaching Certification.

Distinguished High School Teacher.

University Scholarship, Nanjing Normal University, Nanjing, China.

Best High School Student of Jiangyin City.

Memberships of American Chemical Society and American Society of Gene Therapy.

PROFESSIONAL EXPERIENCE (Working experience and projects)

Postdoctoral Fellow –The Johns Hopkins University, Baltimore, MD 08/2008 – Present

Lead a small molecule drug discovery: designed, developed and optimized diverse cell-based and

biochemical primary and secondary assays for early-stage drug discovery, identified novel

neuroprotective agents and evaluated their structure-activity relationship (SAR) and mechanism-

of-action using many biology/biochemistry techniques and related analytical instruments

HPLC, GC-MS, NMR, Fluorescent Spectrophotometry, siRNA transfection, isolation and

characterization of various DNA and RNA, gel electrophoresis including SDS-PAGE, silver and

colloidal blue staining and Imaging.

Published on Annals of Neurology.

Research Assistant – University of Cincinnati, Cincinnati, OH 09/2004 – 05/2008

Focus on synthesizing and characterizing novel agents for biological systems using analytical

instruments and biology/biochemistry techniques including in vitro efficacy, HPLC, GC-MS,

NMR and Fluorescent Spectrophotometry.

Published on Bioorganic & Medicinal Chemistry Letters; Org. Biomol. Chem.; The Journal of Organic

Chemistry.

TEACHING EXPERIENCE

Graduate Teaching Assistant, University of Cincinnati, Cincinnati, OH 09/2004-5/2008

Teach general chemistry and organic chemistry lecture and experiments; Evaluated student

performance through exams, lab efficiency and oral presentation.

Coordinated undergraduate students on special projects and two REU-NSF undergraduate students

on summer projects.

High School Teacher, Jiangyin No. 1 High School, Jiangyin China 09/1999---05/2003

Co-director of high school and chemistry teacher teaching general chemistry.

Director of team for National Chemistry Competition.

Distinguished high school teacher of Jiangyin No.1 High School in 2001, 2002, and 2003.

PUBLICATIONS and PATENT

• Zhu J. and Ahmet Hoke “Ethoxyquin provides neuroprotection via hsp90 to ameliorate

chemotherapy-induced peripheral neuropathy”Annals of Neurology 2013 Dec; 74(6):893-904.

(IF 11.193)

• Zhu, J., McFarland-Mancini, M., Drew, A.F., Smithrud, D.B. “Host-rotaxanes with oligomeric axles

are intracellular transport agents” Bioorganic and Medicinal Chemistry Letters, 19 (2), pp.

520-523. (IF 2.832)

• Zhu, J., House, B.E., Fleck, E., Isaacsohn, I., Drew, A.F., Smithrud, D.B. “A host-rotaxane

derivatized with carboxylic acids efficiently delivers a highly cationic fluoresceinated peptide”

Bioorganic and Medicinal Chemistry Letters, 17 (18), pp. 5058-5062. (IF 2.832)

• Zhu, J. “Host-rotaxanes model proteins that promote ligand association through a favorable

change in configurational entropy” Organic and Biomolecular Chemistry, 5 (18), pp. 2992-

2999. (IF 3.762)

Jing

Zhu,

Ph.D.

3255

Normandy

Woods

Dr.

#D

acdogg@r.postjobfree.com

Ellicott

city,

MD

21043

Phone

(cell):

513

532

9788

• Wang, X.; Zhu, J.; Smithrud, D. B. “Synthesis and investigation of Host-[2] Rotaxanes that Bind

Metal Cations” J. Org. Chem., 2010, 75 (10), pp 3358–3370. (IF 4.002)

• Zhu J. and Hoke A.“Identification of a neuroprotective compound to ameliorate chemotherapy-

induced peripheral neuropathy” J. of PNS, 2011, volumn 16, S158-S159. (IF 3.622)

• Zhu J. and Hoke A.“Identification of a neuroprotective compound to ameliorate chemotherapy-

induced peripheral neuropathy” J. of PNS, 2013. Volumn 18, S130-S131. (IF 3.622)

• Zhu, Jing; Chen, Weiran; Hoke, Ahmet, “An Unbiased Phenotypic Screen Identifies Ethoxyquin as

an Hsp90 Activity Modulating Neuroprotective Compound For Peripheral Neuropathies” Annals of

Neurology, 2012, 72, Supplement: 16, S70-S70. (IF 10.746 )

• Zhu J., Wei Ran Chen and Ahmet Hoke “Ethoxyquin and derivatives for treatment of peripheral

neuropathies and other neurodegenerative disorders” USA patent (14127326).

• Zhu J., Wei Ran Chen and Ahmet Hoke “Ethoxyquin and derivatives for treatment of peripheral

neuropathies and other neurodegenerative disorders” Europe patent (under review).

• Zhu J., Wei Ran Chen and Ahmet Hoke “Ethoxyquin and derivatives for treatment of peripheral

neuropathies and other neurodegenerative disorders” India patent (under review).

MEETING PRESENTATIONS

National:

Zhu J. and Hoke A.“Identification of a neuroprotective compound to ameliorate chemotherapy-

induced peripheral neuropathy” (2013) PNS meeting, Saint-Malo, France.

Zhu J.; Ahmet A. (2011). Identification of a Neuroprotective Compound to Ameliorate

Chemotherapy- Induced Peripheral Neuropathy. National Drug Discovery Meeting, Baltimore, MD.

Zhu J.; Ahmet A. (2011). Identification of a Neuroprotective Compound to Ameliorate

Chemotherapy- Induced Peripheral Neuropathy. PNS meeting, Potomac, MD.

HOKE; J. ZHU. (2011). Identification of a Neuroprotective Compound to Ameliorate Chemotherapy-

Induced Peripheral Neuropathy. National Neuroscience, Washington D.C.

Zhu J.; Smithrud, D. B. (2008). A Host-Rotaxane derivatized with a crown-6 as high selective metal

binding agent, 235nd ACS National Meeting, New Orleans, LA.

Zhu J.; Smithrud, D. B. (2007). Rotaxane dynamics in cellular transport. 233nd ACS National

Meeting, Chicago, Il.

Regional:

Zhu J. (2009). Development of Novel Therapies for Peripheral Neuropathies. Neuroscience meeting,

The Johns Hopkins University, MD.

Zhu J.; Smithrud, D. B. (2008). A Host-Rotaxane derivatized with a crown-6 as high selective metal

binding agent. Nighth Annual Graduate Poster Forum, University of Cincinnati, OH.

Zhu J.; Smithrud, D. B. (2007). Creating transporters to test the dynamic effects in intracellular

delivery, University of Cincinnati, Cincinnati, OH.

Zhu J.; Smithrud, D. B. (2007). Rotaxane dynamics in cellular transport. Eigth Annual Graduate

Poster Forum, University of Cincinnati, OH.

Zhu J.; Smithrud, D. B. (2006). Rotaxane dynamics in cellular transport. Oesper Symposium,

University of Cincinnati, Cincinnati, OH.

Zhu J.; Smithrud, D. B. (2006). Creating transporters to test the dynamic effects in intracellular

delivery. Seventh Annual Graduate Poster Forum, University of Cincinnati, OH.

Zhu J., Smithrud, D. B.; Stone, V. (2005). Novel [2]-Rotaxanes as Protein Mimetics. Oesper

Symposium, University of Cincinnati, Cincinnati, OH.

Zhu J.; Smithrud, D. B. (2005). Rotaxanes as Protein Mimetics. Sixth Annual Graduate Poster Forum,

University of Cincinnati, OH.

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