Zhihui (Jay) Zhang, Ph.D.

Home address: Working address:

The HallStar Company

**** * ******** *****

**** *. **** ******

New Berlin, WI 53151

Bedford Park, IL 60637

Tel: 404-***-**** (cell)

Email: acdfem@r.postjobfree.com

Email: acdfem@r.postjobfree.com

SUMMARY

Accomplished chemist with strong knowledge and experience in chemical synthesis, formulation, process development

and technology transfer; Proven track record of innovations in new product development; Strong skills of project

management; Knowledge and experience in statistical experimental design and analysis (DoE) and continuous

improvement (Kaizen).

Process chemistry expertise in process development and optimization as well as technology transfers to manufacture

site or CMO/CRO.

Synthetic organic chemistry extensive experience in synthesizing small molecules, developing methodology and solving

challenging synthetic problems.

Polymer chemistry industrial experience in preparation and modification of polymer materials to address customers’

need for sustainable products.

Experience in modern analytical techniques (NMR, MS, LC, HPLC, GC, GC/MS, UV-Vis, IR, etc.).

Experience in working with manufacturing and marketing to commercialize new products; Experience of working with

sales and customers to qualify new or existing products.

Excellent communication skills (verbal & written), able to work and communicate with team members of other

disciplines and with different levels of expertise.

Authored 3 filed patent applications, 10+ journal papers and conference presentations

WORK ELIGIBILITY

U.S. Permanent Resident

WORK EXPERIENCE

Senior Research Chemist

The HallStar Company, Chicago, IL 01/2013-Present

Planned, performed and directed research projects for successful commercialization of products: idea generation, product

synthesis, purification, characterization, formulation testing, technology transfer to manufacturing and support of

manufacturing and sales. Coordinated research groups to meet project objectives and managed laboratory personnel

involved in product development.

Lead small molecule discovery project to identify novel chemical ingredients in next generation cosmetic products

(Patent).

Manage the project of design and synthesis of film forming polymers with novel photochemical property in support of

developing innovative materials.

Postdoctoral Scholar

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University of Chicago, Chicago, IL 01/2011-12/2012

Developed a general approach for the preparation of unprotected and N-protected organometallic amino acids

and directly incorporated them into peptides and proteins.

Established catalytic activities of several metalopeptides in organic reactions.

University of Pennsylvania, Philadelphia, PA 11/2009-12/2010

Collaborated with Wistar Institute to design and synthesize two steroid-derived analogues as metabolically stable

inhibitors of hedgehog signaling. The lead compounds were more potent than original Cyclopamine in a few cancer cell

lines.

Collaborated with Department of Medicine to investigate the synthesis of heteroalkane-bridged bisquinoline analogues

and a structure-activity analysis using autophagy and cytotoxicity assays as the biological reporters of activity. This work

identified the lead compound, Lys01, as a 10-fold more potent autophagy inhibitor than previous analogues.

Graduate Research Assistant

Emory University, Atlanta, GA 08/2004-08/2009

Discovered a new synthetic approach to amide and peptide constructions through in situ carboxyl activation using a

silatropic switch strategy (Patent).

Developed the 2nd- generation of Liebeskind-Srogl cross coupling reaction involving Cu (I) catalyzed carbon carbon

bond forming process in the presence of strongly binding thiolate ligands.

Achieved the first metal catalyzed cyanation of boronic acids under cyanide-free and pH neutral conditions through

Pd(0)-catalyzed cross-coupling of boronic acids and thiocyanates.

Developed a mild protocol for amide formation through Cu(I)-mediated cross-coupling of organostannanes or boronic

acids and hydroxamic acid derivatives under non-basic and non-oxidizing conditions.

Lanzhou University, Lanzhou, China 09/2001-06/2004

Invented a concise preparation of optically pure -hydroxy- -amino acids from chiral tricyclic iminolactone derived

from natural camphor (Patent).

Synthesized and characterized a variety of heterocyclic compounds containing cinchopheny for biological evaluations.

PATENTS

1. Zhang, Z.; Bonda, C. A, Hu, S. R. “Photostabilization of Aryl Substituted Propenoic Amides and Thioesters.”

Provisional patent filing (2013).

2. Liebeskind, L. S.; Wu, W.; Zhang, Z.; Li, H.; Angus A. Lamar. “Process for the Formation of Amide, Peptide Bonds,

and Glycopeptide Bonds.” Series Number 13/280,991 (2011).

3. Xu, P.-F.; Zhang, Z.; Li, S. “Method for Preparation of Template for the Synthesis of -Hydroxy- -Amino Acids and Its

Derivatives.” Chinese Patent, Series Number 03134969.2 (2004).

EDUCATION

08/2009

Ph.D. Organic Chemistry, Emory University, Atlanta, USA

06/2004

M.S., Organic Chemistry, Lanzhou University, China

06/2001

B.S., Chemistry, Lanzhou University, China

AWARDS AND HONORS

2009

Osborne R. Quayle Award for Excellence in Chemical Research, Emory University

2004

Hai Zheng Distinguished Graduate Fellowship, Lanzhou University

1998-2001

Annual Outstanding Undergraduate Scholarships, Lanzhou University

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PUBLICATIONS AND PRESENTATIONS

1. Zhang, Z.; Yang, H.; Zhang, C.; Lewis, J. C. “Synthesis and Catalytic Activity of Organometallic Amino Acids and

Metallopeptides.” Organometallics 2012, 31, 7328.

2. McAfee, Q.; Zhang, Z.; Samanta, A.; Levi, S. M.; Ma, X.-H.; Piao, S.; Lynch, J. P.; Uehara, T.; Sepulveda, A. R.; Davis,

L. E.; Winkler, J. D.; Amaravadi, R. K. “Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces

the phenotype of a genetic autophagy deficiency.” Proc. Nat. Acad. Sci. USA 2012, 109, 8253.

3. Zhang, Z.; Lindale, M. G.; Liebeskind, L. S. “Mobilizing Cu(I) for Carbon-Carbon Bond Forming Catalysis in the

Presence of Thiolate. Chemical Mimicking of Metallothioneins.” J. Am. Chem. Soc. 2011, 133, 6403.

4. Wu, W.; Zhang, Z.; Liebeskind, L. S. “In Situ Carboxyl Activation Using a Silatropic Switch: A New Approach to Amide

and Peptide Constructions.” J. Am. Chem. Soc., 2011, 133, 14256.

5. Zhang, Z.; Baubet, V.; Ventocilla, C.; Xiang, C.; Dahmane, N.; Winkler, J. D. “Stereoselective Synthesis of F-ring

Saturated Estrone-Derived Inhibitors of Hedgehog Signaling Based on Cyclopamine.” Org. Lett., 2011, 13, 4786.

6. Li, Q.; Yang, S.-B.; Zhang, Z.; Li, L.; Xu, P.-F. “Diastereo- and Enantioselective Synthesis of β-Hydroxy-α-Amino Acids:

Application to the Synthesis of a Key Intermediate for Lactacystin.” J. Org. Chem. 2009, 74, 1627–1631.

7. Zhang, Z.; Yu, Y.; Liebeskind, L. S. “N-Amidation by Copper-Mediated Cross-Coupling of Organostannanes or Boronic

Acids with O-Acetyl Hydroxamic Acids.” Org. Lett. 2008, 10, 3005.

8. Zhang, Z.; Liebeskind, L. S. “Palladium-Catalyzed, Copper (I)-Mediated Coupling of Boronic Acids and

Benzylthiocyanate. A Cyanide-Free Cyanation of Boronic Acids.” Org. Lett. 2006, 8, 4331.

9. Xu, P.-F.; Zhang, Z.; Hui, X.-P.; Zhang, Z.-Y.; Zheng, R.-L. “Synthesis of Triazoles, Oxadiazoles and Condensed

Heterocyclic Compounds Containing Cinchophen and Studies on Biological Activity of Representative Compounds.”

J. Chin. Chem. Soc. 2004, 51, 315-319.

10. Zhang, Z.; Liebeskind, L. S. “New Metallothionein Mimic Copper-Catalyzed Cross-Coupling of Thioester and Boronic

acid.” 236th ACS National Meeting, Philadelphia, PA, August 17-21, 2008, ORGN-689.

11. Zhang, Z.; Liebeskind, L. S. “Copper(I)-Mediated Amination of Organostannanes with Hydroxylamine Derivatives.”

234th ACS National Meeting, Boston, MA, August 19-23, 2007, ORGN-732.

12. Zhang, Z.; Liebeskind, L. S. “New Cyanation Reaction of Boronic Acids.” 231st ACS National Meeting, Atlanta, GA,

March 26-30, 2006, ORGN-320.

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