Chunli Huang

Scotch Plains, NJ acd8eu@r.postjobfree.com

908-***-**** www.linkedin.com/in/chunlihuang

SUMMARY

Self-motivated, goal-oriented Chemist with R&D laboratory working experience in

pharmaceutical industry. Thorough knowledge of pharmaceutical processes and

established SOPs. Extensive analytical skills and hands-on experience in small scale

sample handling and report writing with proven accuracy and precision. Exceptional

ability in following and performing procedures, delivering results and maintaining

accurate notebooks with strong attention to detail. Recognized by management for

efficient operation and collaboration on tight timelines. Seeking an Analytical

Technician position to support and contribute to the successful fulfillment of ongoing

projects.

TECHNICAL SKILLS

Solid knowledge and integrate techniques in operating NMR for sample analysis and

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characterization, familiar with computer software to process and obtain NMR spectra

Analytical laboratory method development using modern chromatography, spectroscopic

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instruments for sample analysis/testing, including HPLC, UPLC, and LCMS

Quick learner and able to work independently with multitasking and problem solving skills

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Proficiency with Acrobat, MS Word, Excel, PowerPoint and other documentation skills

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Excellent listening, strong written and verbal communication/organizational skills

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PROFESSIONAL EXPERIENCE

MERCK& CO., INC. 2009-2013

Merck Research Laboratories, Discovery and Preclinical Science, Kenilworth, New Jersey

Scientist (2012-2013)

Associate Scientist (2009-2012)

Investigated various series of targets and made project-driven contributions on MK-8931 (currently

in Phase III Clinical Trials) BACE Inhibitor program for treating Alzheimer’s Disease.

• Routinely provided quality control of research materials and intermediates by following

guidelines precisely. Conducted the analysis and characterization of numerous samples and

final products using NMR and LCMS in support of study designs and timely submissions.

• Demonstrated “Can Do” attitude, especially in trouble shooting a key procedure that

allowed significantly improved access to new leads at an early stage. Increased the yield

from 0 to 90%. Saved the team much time and efforts both internally and externally.

• Collaborated with different functional groups and improved work efficiency at least two

folds. Accelerated and assisted team to make a clear go/no-go decision in a timely manner.

• Validated various research procedures, including a 16-step preparation of a very potent yet

complex series of molecules by solving challenging problems for some key steps.

• Presented a poster with promising results at Women in Chemistry Symposium.

• Drafted and reviewed technical packages efficiently for competitor compounds in a timely

manner. Followed instructions and procedures precisely and accurately.

• Managed the logistics of timely delivery of samples/intermediates across sites and to

international CRO companies through collaboration with shipping department.

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SCHERING-PLOUGH CORPORATION 2003-2009

Schering-Plough Research Institute (SPRI), Kenilworth, New Jersey

Associate Scientist (2005-2009)

Assistant Scientist (2003-2005)

• Played an instrumental role in the SAR development of CB1 Antagonist for treating

Obesity. Prepared numerous target molecules of various series with good potency. Prepared

the predecessor and contributed significantly to the discovery of Sch-792816 which was

chosen by Animal Health and currently under clinical trials for canine obesity.

• Investigated and advanced the CB2 Inverse Agonist project for the treatment of Multiple

Sclerosis. Developed a practical, preparative chiral HPLC separation and obtained the key

intermediate in sufficient quantities in support of SAR development. Prepared many

derivatives that culminated in the discovery of the lead target and resulted in a patent.

• Facilitated and ensured timely delivery of a potential candidate with sufficient quantities for

further testing. Contributed and prepared many intermediates for project team use.

• Participated in the design, preparation and characterization of target molecules of Glucagon

Antagonist for Diabetes. Assisted the identification of a core structure to improve potency.

NOVARTIS PHARMACEUTICAL CORPORATION 2002

Department of Metabolic and Cardiovascular Diseases, Summit, New Jersey

Scientist II

Engaged in the preparation and characterization of enzyme inhibitors for the treatment of Diabetes.

• Routinely used analytical HPLC for purity analysis and method development. Frequently

performed preparative HPLC separation to ensure the purity and quality of final products.

• Wrote biweekly/monthly reports and presented results at project meetings.

EDUCATION

M.S. in Medicinal & Biological Chemistry, The University of Toledo, Toledo, Ohio.

M.S. in Medicinal Chemistry, East China University of Science and Technology (ECUST),

Shanghai, P.R.China.

B.E. in Pharmaceutical Technology, ECUST, Shanghai, P.R.China.

SUPPLEMENTAL EDUCATION AND TRAINING

In-House Courses and Trainings at Merck & Co., Inc., 2009-2013

• OSHA Lab Standard • Occupational Exposure Band (OEB) System Training

• Good Documents • Electronic Laboratory Notebook (ELN) for Chemists

• Intellectual Property 101 • Pharmacology of Drug Discovery

• Overview of In Silico ADMET • Neuroscience for Chemists

HONORS AND AWARDS

Shining Performance Awards at Merck & Co., Inc., 2009 and at Schering-Plough Corportion, 2006.

"Sunshine Engineering" Scholarship sponsored by Jiuhuan Company, Inc., P.R.China, 1995.

"Outstanding Graduate" awarded by Bureau of Shanghai Higher Education, P.R.China, 1993.

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Chunli Huang

PROFESSIONAL ADDENDUM

PROFESSIONAL AFFILIATION

American Chemical Society

PATENT AND PUBLICATIONS

Shankar, Bandarpalle B.; Gilbert, Eric J.; Rizvi, Razia K.; Huang, Chunli; Kozlowski, Joseph A.;

McCombie, Stuart W.; Shih, Neng-Yang. ”Preparation of Cannabinoid Receptor Ligands. “ PCT

Int. Appl. 2006, WO 200-***-****/USP 581837/EU 05766578.8-2101/1768667.

Gilbert, Eric; Huang, Chunli; Stamford, Andrew; Cumming, Jared; Greenlee, William; Kennedy,

Matthew; Parker,Eric; Kuvelkar, Reshma; Cox, Kathleen; Voight, Johannes; et al. “ Pyrrolidine-

fused iminoheterocycles as BACE1 inhibitors for the treatment of Alzheimer's disease.” Abstracts of

Papers, 244th ACS National Meeting & Exposition, Philadelphia, PA, United States, August 19-23,

2012(2012), MEDI-101.

Scott, Jack D.; Li, Sarah W.; Gilbert, Eric J.; Huang, Chunli; Cumming, Jared; Iserloh, Ulrich;

Mazzola, Robert D.;Babu, Suresh; Caldwell, John; Chen, Xia; et al. “Novel iminopyrimidinone b-

secretase (BACE) inhibitors: P1-thiophenes.” Abstracts of Papers, 241st ACS National Meeting &

Exposition, Anaheim, CA, United States, March 27-31, 2011(2011), MEDI-36.

Tong, Ling; Shankar, B. B.; Chen, Lei; Rizvi, Razia; Kelly, Joseph; Gilbert, Eric J.; Huang,

Chunli, Yang, De-Yi; Kozlowski, Joseph A.; Shih, N.-Y.; et al. " Expansion of SAR Studies on

TriarylBisSulfone Cannabinoid CB2 Receptor Ligands." Bioorganic & Medicinal Chemistry

Letters, 2010, 20, pp6785-6789.

Gilbert, Eric J.; Zhou, Guowei; Wong, Michael K. C.; Tong, Ling; Shankar, Bandarpalle B.;

Huang, Chunli; Kelly, Joseph; Lavey, Brian J.; McCombie, Stuart W.; Chen, Lei; et al. "Non-

aromatic A-ring Replacement in the TriarylBis-sulfone CB2 Receptor Inhibitors." Bioorganic &

Medicinal Chemistry Letters, 2010, 20, pp608-611.

Gilbert, Eric J.; Miller, Michael W.; Huang, Chunli; Scott, Jack D.; Stamford, Andrew W.;

Greenlee, William J.; Li,Sarah W.; Weinstein, Jay; Kowalski, Timothy J.; Spar, Brian D.; et al.

“Novel 1,2-diarylpiperazines as CB1 antagonists.” Abstracts of Papers, 239th ACS National

Meeting, San Francisco, CA, United States, March 21-25, 2010 (2010),MEDI-209.

Liu, Qinfeng; Inoue, Takayo; Kirchhoff, Jon R; Huang, Chunli; Tillekeratne, L.M.V.; Olmstead,

Kay; Hudson, Richard A. “Chiral Separation of Highly Negatively Charged Enantiomers by

Capillary Electrophoresis.” Journal of Chromatography A, 2004, 1033, pp 349-356.

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