SHEETAL VALI, PHD

*** ******* ***** ******, *********, TX 76092 • 214-***-**** • acd7ci@r.postjobfree.com

• VISA STATUS: US PERMANENT RESIDENT (GREEN CARD) • FULL CV AVAILABLE AT:

HTTPS://WWW.LINKEDIN.COM/IN/SHEETALVALI

PROFESSIONAL SCIENTIST IN BIOMEDICAL RESEARCH, WITH OVER 10 YEARS OF EXPERIENCE IN

ACADEMIC AND FDA REGULATED PHARMACEUTICAL INDUSTRY RESEARCH AND DEVELOPMENT

EXPERIENCE.

EDUCATION

2006-2010 DOCTOR OF PHILOSOPHY (PHARMACEUTICS), BHARATI VIDYAPEETH UNIVERSITY, INDIA

2001-2003 MASTER OF SCIENCE (PHARMACEUTICS), BHARATI VIDYAPEETH UNIVERSITY, INDIA

1997-2001 BACHELOR OF SCIENCE (PHARMACY), MARATHWADA UNIVERSITY, INDIA

PROFESSIONAL EXPERIENCE

2011-2014 • POSTDOCTORAL RESEARCHER II • DEPT. OF PHYSIOLOGY • UT SOUTHWESTERN MEDICAL

CENTER, DALLAS, TX

DEVELOPED PEPTOIDS AS THERAPEUTICS FOR ALZHEIMER'S DISEASE.

DEVELOPED HIGHLY SPECIFIC BINDING PROTEIN AND PEPTOID FOR TARGETING THE HUMAN

HUNTINGTIN (HTT) PROTEIN.

TECHNICAL SKILLS:

PEPTOID CHEMISTRY: SYNTHESIS, LIBRARY BUILDING AND SCREENING.

BIOCHEMISTRY AND MOLECULAR BIOLOGY: PCR, DNA SEQUENCING, CLONING, EXPRESSION,

PURIFICATION, REFOLDING, WESTERN BLOTTING AND SDS-PAGE.

ANALYTICAL CHEMISTRY: MOLECULAR SIZE EXCLUSION CHROMATOGRAPHY, ISOTHERMAL

TITRATION CALORIMETRY, HPLC, XRD, MASS SPECTROSCOPY AND FLUORESCENCE MICROSCOPY.

CRYSTALLOGRAPHY: PROTEIN CRYSTALLOGRAPHY, X-RAY CRYSTALLOGRAPHY INCLUDING

SYNCHROTRON DATA COLLECTION, DATA PROCESSING AND REFINEMENT USING CCP4 SUITE AND

COOT SOFTWARE.

MENTORING EXPERIENCE: MENTORED AND SUPERVISED RESEARCH TECHNICIANS, GRADUATES &

UNDERGRADUATE STUDENTS AND SUMMER INTERNS.

PHARMACEUTICAL EXPERIENCE

2006-2010 • DOCTORAL WORK • DEPT. OF PHARMACEUTICS • BHARATI VIDYAPEETH UNIVERSITY •

INDIA

DOCTORAL DISSERTATION TITLED “DESIGN AND EVALUATION OF NANOPARTICULATE DRUG

DELIVERY SYSTEM” AND FOCUSED ON METAL NANOPARTICLES, BIO-IMAGING, AND IN VITRO AND IN

VIVO DRUG DELIVERY APPLICATIONS.

DEVELOPED GOLD NANOPARTICLES AS A VEHICLE FOR THE DELIVERY OF DOXORUBICIN

HYDROCHLORIDE IN VARIOUS HUMAN CANCER CELL LINES.

EXAMINED THE CELLULAR UPTAKE (CANCER CELL LINE) AND IN VIVO ORAL TOXICITY (WISTAR

RATS) OF GOLD NANOPARTICLES.

DEVELOPED SILVER NANOPARTICLES DISPERSION AND GELS AS ANTIMICROBIAL AGENT FOR

TOPICAL APPLICATION.

TECHNICAL SKILLS:

NANOPARTICLES: SYNTHESIS USING GOLD AND SILVER.

ANALYTICAL CHEMISTRY: UV, FTIR, DSC, HPLC, DLS, MASS SPECTROSCOPY, FLUORESCENCE

SPECTROSCOPY, LYOPHILIZER AND PARTICLE SIZE ANALYZER.

CELLULAR IMAGING: FLUORESCENCE MICROSCOPY, CONFOCAL MICROSCOPY.

IPR: PATENT LITERATURE AND DRAFTING.

PUBLISHED FOUR FIRST AUTHOR PEER-REVIEWED PAPERS INCLUDING PERSPECTIVE ARTICLE

FEATURED ON COVER PAGE.

PHARMACEUTICAL INDUSTRY EXPERIENCE

2003-2005 • RESEARCH ASSOCIATE (R&D) • LUPIN PHARMACEUTICALS INC. • INDIA

DESIGN AND DEVELOPMENT OF DRUGS FOR INDIA MARKET AND ANDA FOR REGULATED

MARKETS.

INSTRUMENTAL IN COMPLETING SEVERAL PROJECTS FROM PROJECT INITIATION TO PILOT

BATCH TO MEET CLINICAL AND REGULATORY NEEDS; PROJECTS INCLUDED TABLETS (CONVENTIONAL,

CONTROLLED RELEASE, SUSTAINED RELEASE, ENTERIC COATED), CAPSULES, TABLETS-IN-CAPSULE,

SYRUPS, SUSPENSIONS (LIQUIDS AND DRY POWDER), CREAMS AND OINTMENTS.

PERFORMED STABILITY STUDIES AS PER THE ICH GUIDELINES.

TECHNICAL SKILLS:

INSTRUMENTATION: TABLET COMPRESSION, TABLET COATING, RAPID MIXER GRANULATOR,

FLUIDIZED BED PROCESSOR, CAPSULE FILLING, DISSOLUTION APPARATUS, UV, FTIR, DSC AND HPLC.

LEADERSHIP EXPERIENCE

EXECUTIVE BOARD MEMBER, POSTDOCTORAL ASSOCIATION AT UT SOUTHWESTERN.

CO-CHAIR SOCIAL COMMITTEE, POSTDOCTORAL ASSOCIATION AT UT SOUTHWESTERN.

DEPARTMENT REPRESENTATIVE, DEPT. OF PHYSIOLOGY, POSTDOCTORAL ASSOCIATION AT UT

SOUTHWESTERN.

PUBLICATIONS

1. SHEETAL VALI, ET. AL. AΒ42-BINDING PEPTOIDS AS AMYLOID AGGREGATION INHIBITORS AND

DETECTION LIGANDS. ACS CHEMICAL NEUROSCIENCE, 2013, 4, 952-962 (I.F.: 3.871, C.I.: 4).

HTTP://PUBS.ACS.ORG/DOI/ABS/10.1021/CN400011F

2. SHEETAL DHAR, ET. AL. GELLAN GUM CAPPED SILVER NANOPARTICLES DISPERSION AND

HYDROGELS: CYTOTOXICITY AND IN VITRO DIFFUSION STUDIES.

NANOSCALE, 2012, 4, 563-567 (I.F.: 6.233, C.I.: 6).

HTTP://PUBS.RSC.ORG/EN/CONTENT/ARTICLELANDING/2012/NR/C1NR10957J/UNAUTH

3. SHEETAL DHAR, ET. AL. CYTOTOXICITY OF SOPHOROLIPID-GELLAN GUM-GOLD NANOPARTICLES

CONJUGATES AND THEIR DOXORUBICIN LOADED DERIVATIVES TOWARDS HUMAN GLIOMA AND HUMAN

GLIOMA STEM CELL LINES.

NANOSCALE, 2011, 3, 575-580 (I.F.: 6.233, C.I.: 17).

HTTP://PUBS.RSC.ORG/EN/CONTENT/ARTICLELANDING/2011/NR/C0NR00598C

HIGHLIGHTED: NANO EHS A VIRTUAL JOURNAL. HTTP://ICON.RICE.EDU/VIRTUALJOURNAL.CFM

4. SHEETAL DHAR, ET. AL. BIOCOMPATIBLE GELLAN GUM REDUCED GOLD NANOPARTICLES:

CELLULAR UPTAKE AND SUBACUTE ORAL TOXICITY STUDIES.

JOURNAL OF APPLIED TOXICOLOGY, 2011, 31, 411-420 (I.F.: 2.597, C.I.: 12).

HTTP://ONLINELIBRARY.WILEY.COM/DOI/10.1002/JAT.1595/ABSTRACT

5. VARSHA POKHARKAR, SHEETAL DHAR, ET. AL. EFFECT OF PENETRATION ENHANCERS ON GEL

FORMULATION OF ZIDOVUDINE: IN VIVO AND EX VIVO STUDIES.

PDA JOURNAL OF PHARMACEUTICAL SCIENCE & TECHNOLOGY, 2010, 64, 337-347 (C.I.: 4).

HTTP://JOURNAL.PDA.ORG/CONTENT/64/4/337.ABSTRACT

6 SHEETAL DHAR AND VARSHA POKHARKAR. FORMULATION DEVELOPMENT OF MUCOADHESIVE

MATRIX TABLET FOR METFORMIN

HYDROCHLORIDE: IN VITRO AND IN VIVO EVALUATION.

RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY, 2010, 3, 483-489.

HTTP://RJPTONLINE.ORG/PDF/RJPT_3_2_2010_CONTENT.PDF

7. VARSHA POKHARKAR, SHEETAL DHAR, ET. AL. ACUTE AND SUBACUTE TOXICITY STUDIES OF

CHITOSAN REDUCED GOLD NANOPARTICLES: A NOVEL CARRIER FOR THERAPEUTIC AGENTS.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2009, 5, 233-239 (I.F.: 5.256, C.I.: 22).

HTTP://WWW.ASPBS.COM/JBN/

8. VARSHA POKHARKAR, ABHISHEK KHANNA, VINOD VENKATPURWAR, SHEETAL DHAR, LEENATA

MANDPE. TERNARY COMPLEXATION OF CARVEDILOL, Β-CYCLODEXTRIN AND CITRIC ACID FOR

DEVELOPING MOUTH DISSOLVING TABLET FORMULATION.

A CTA P HA RMA CE UTI CA, 2 00 9, 59, 12 1 -13 2 (I.F.: 1.162, C.I.: 19).

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%3A 2 & FRO M=1 95 64 1 41

9. SHEETAL DHAR, ET. AL. NATURAL GUM REDUCED/STABILIZED GOLD NANOPARTICLES FOR DRUG

DELIVERY FORMULATIONS.

CHEMISTRY EUROPEAN JOURNAL, 2008, 14, 102**-***** (COVER PAGE ARTICLE, I.F.: 5.831, C.I.: 64).

HTTP://ONLINELIBRARY.WILEY.COM/DOI/10.1002/CHEM.200801093/ABSTRACT

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