Ruoshi Li 216-***-**** (Cell)

acczck@r.postjobfree.com

*** ******** **., **********, **, 75080

SUMMARY

Highly motivated Ph.D. in Chemical Engineering is seeking a full-time position

related to chemical product design, development, and testing to add valuable

assets as an active member. Diverse research background in Chemical

Engineering, Chemistry, and Materials Engineering. Strong in analytical method

development and results-delivering R&D.

CORE COMPETENICIES

Proven Results-Delivering R&D Achievements:

Key inventor for a novel ultrasonic degradation method of natural polymers

(fully funded by Nestl USA).

Key designer for 3 series of radiolabeling strategies and tracers used in

clinical study (fully funded by NIH).

Key inventor for the first Pd-catalyzed simple arene C-H activations (SP2-SP3

and SP2-SP2), and the first Fe-catalyzed simple arene alkenylation (with 200+

citations).

Technical Writing: Authored 2 patent applications, 7 high-impact peer-reviewed

articles, 5 conference proceedings, 20+ SOPs for reagent preparation/assay

procedure/equipment, and 6 laboratory hygiene and safety plans; reviewed 80+

publications for 18 accredited peer-reviewed journals.

Project Management and Budget Planning: Involved in 8+ projects from NIH, NMSS,

NSF, NSFC, Nestl USA, and Volkswagen China; authored 2 CMC protocols for IND

and RDRC applications with FDA; participated in 4 grant application and

management ($1.5M NIH/NINDS R01; $0.5M NMSS; $0.1M MRF; $30,000 CCTRC).

Teamwork and Leadership: Efficiently cooperate with colleagues of diverse

background in a fast-paced environment; served as a group leader in paint shop

at Volkswagen China and supervised 5 junior engineers; trained 40+ students for

experimental design and process; advised 10+ student for compound synthesis,

isolation, analysis, and characterization.

Laboratory Management: Received professional trainings in GTD and

multi-task/time management; expertise in DOE and laboratory data base

maintenance and update; 6-year experience in supervising laboratory safety and

familiar with QC, FMEA, cGMP, MSDSs, EHS, and OSHA regulations (chemicals,

radiation, laser, small animal, and regular laboratory safeties), 5-year

experience in optimizing lab resources to resolve problems and deliver

solutions to support multiple projects in a timely fashion.

Selected Courses: Transport Phenomena, Transport Principle for Chemical

Process, Chemical Engineering Analysis, Materials Engineering Design,

Thermodynamics, Chemical Reaction Engineering, Materials Engineering Design,

Equipment for Inorganic Materials, Inorganic Materials Processing Technology,

Structures and Properties of Materials, Materials Characterization Methods,

Advanced Organic Chemistry, Advanced Inorganic Chemistry, Applied

Photochemistry.

EDUCATION & CERTIFICATION

Ph.D. in Chemical Engineering, Case Western Reserve University 10/2013

(CWRU), Cleveland, OH

Certificate: Six Sigma Green Belt, Aveta Business Institute, 06/2013

Boardman, OH

M.S. in Chemical Engineering, Case Western Reserve University 05/2013

(CWRU), Cleveland, OH

M.S. in Organic Chemistry, Shanghai Jiao Tong University (SJTU), 05/2008

China

B.S. in Materials Science and Engineering & Computer Science, 06/2004

Tongji University, China

SKILLS & EXPERTISE

Material Characterization: NMR, LC/MS, MS/MS, FT-IR, UV/Vis, SEM, DLS, SEC,

TGA, DSC, GC, HPLC, etc.

Material Preparation: organic/bio-molecular reagent synthesis and preparation,

polymer modification and degradation, polymer extrusion, C-11 & F-18

radiolabelling, peptide labelling.

Data Processing and Analyses: SAS, OriginLab, MATLAB, Microsoft Excel,

Mathematica, Minitab, SPSS.

Professional Applications: SciFinder Scholar, Image-J, MestRe-C, AutoCAD,

ChemOffice Suite, MathType, MathPad, Microsoft Office Suite, LabVIEW, ChemCAD,

C, Pascal.

Language and Communication: Fluent in English and Mandarin, with excellent

communication skills; 20+ presentation experience at academic

conferences/seminars and company meetings.

PROFESSIONAL EXPERIENCE

Research Assistant, Fine Particle Laboratory, CWRU, Cleveland, OH 08/2010 -

10/2013

Discovered the salting-in/out effects on the molecular conformational change,

successfully applied this theory on ultrasonic degradation of polymers in

dissolved or suspended phase. Quantified the rheological properties of

sonication treated solutions, built degradation kinetics models, predicted and

optimized the degradation procedure.

Evaluated the influence of specific functional groups on the molecular chain's

stability and degradation efficiency by preparing modified/denatured polymers,

testing molecular thermal stabilities, calculating degradation kinetics.

Collaborated with Nestl USA on coffee beverage study. Developed an efficient

way on degradation, isolation, and recycling of waste coffee grounds (WCGs),

provided a potential and commercial use of WCGs.

Maintained DLS, zeta potential, UV-Vis, laser counter, viscometry, and

ultrasound equipments. Trained 10+ collaborators from Chemical Engineering,

Chemistry, Physics, Macromolecule Science, Earth Science, etc.

Trouble shoot problems and repaired equipments. Analyzed root causes for

technical problems based on structural-property relationships, proposed action

plans for improvement, provided instructions for analytical methods.

Research Assistant, Case Center for Imaging Research, CWRU, 08/2008 -

Cleveland, OH 07/2010

Designed a novel radiosynthesis strategy of C-11 used for radiolabelling amine

compounds and peptides. Investigated and validated the radiolabeling sites on a

series of peptides through LC/MS and MS/MS analysis.

Developed and synthesized a C-11 labeled radiotracer ([11C]SU11274) used as the

mesenchymal-epithelial transition (MET) receptor for in vivo imaging study

(PET).

Prepared 3 species of C-11 and F-18 labeled novel drugs for the University

Hospitals' in vivo imaging study of myelin pathology and in vivo evaluation of

cancer chemotherapy through PET and MRI.

Cooperated with Siemens' PETNET Solutions in novel radiosynthesis method

development. Developed a radiosynthesis strategy for C-11 labeled benzaldehyde

preparation with less steps, and higher radiochemical yields.

Participated in 4-grant applications (NIH, NMSS, MRF, CCTRC) and assisted

budget planning. Prepared 2 CMC protocols for new drug's IND and RDRC approvals

from FDA.

Managed the radiopharmaceutical lab facility, operated and maintained 10+

equipments, including HPLC, FT-IR, GC, cyclotron, and automatic radiosynthesis

module, etc. Responsible for laboratory safety, prepared 6 hygiene and safety

plans and authored 10+ SOPs. Trained 5 collaborators for radiosynthesis and

purification.

Research Assistant, Transition Metal Catalysis Laboratory, SJTU, 09/2005 -

Shanghai, China 05/2008

Developed and explored the first Pd(II)-catalyzed cross-coupling reaction of

simple arenes via C-H activation with high selectivity, validated the catalysis

mechanism through KIE study, optimized reaction conditions to increase TON.

Developed and explored the first Pd(II)-catalyzed cross-coupling reaction of

p-Xylene via regioselective C-H activation (SP2-SP3/SP2-SP2), validated two

catalysis routes through KIE study.

Developed a novel Fe(III)-catalyzed alkenylation of simple arenes with high

yields to replace noble/rare metal catalysts, explored the reaction scope,

confirmed reaction mechanism through the kinetics and thermodynamics studies.

Participated in NSFC grant application. Responsible for budget planning, new

instrument purchase, testing, and justification reports. Maintained laboratory

facilities, including 2 GCs, HPLC, and 5 laboratory computers, proposed and

implemented lab policies & rules, trained both internal group members and

external users.

Process Engineer, Paint Shop, Shanghai Volkswagen (SVW), 08/2004 -

Shanghai, China 08/2005

Supervised a group of 5 junior engineers/technicians on two projects.

Assisted R&D department in optimizing paint process, reducing photo-oxidative

decomposition of cathodic electrodeposition coatings (CED) caused by

UV-transmission.

Developed analytical methods for eventual QC release testing of active

ingredients and finished products.

Coordinated with chemical vendors to control specific material parameters with

an emphasis on Continuous Improvement.

Built and updated the production data files. Reported to higher management for

project progress and plans. Assisted budget planning and workload management.

Authored progress reports and annual project report.

PATENTS

'Iron Catalyzed Styrene Derivative Synthesizing Process with Active Arene and

Alkyne' 2007, CN200610148226.

'Process for Preparing Arene Bromo-Derivative' 2007, CN200610148225.

HONORS AND SCHOLARSHIPS

Graduate Assistantship, Nestl USA 08/2010 -

10/2013

Graduate Assistantship, National Institutes of Health (NIH) 08/2008 -

07/2010

Dow Chemical Scholarship (Top 1 of 80), The Dow Chemical Company 09/2006 -

07/2007

Graduate Fellowship, Natural Science Foundation of China (NSFC) 09/2005 -

07/2008

Excellent Student Scholarship, Tongji University 09/2002 -

07/2003

PUBLICATIONS

Ruoshi Li; Donald L. Feke* 'Rheological and Kinetics Study of Ultrasonic

Degradation of Xanthan Gum in Aqueous Solutions 1: Effects of Salt', submitted

and under review.

Ruoshi Li; Donald L. Feke* 'Rheological and Kinetics Study of Ultrasonic

Degradation of Xanthan Gum in Aqueous Solutions 2: Effects of Pyruvate Group',

submitted and under review.

Ruoshi Li; Donald L. Feke* 'Rheological and Kinetics Study of Ultrasonic

Degradation of Locust Bean Gum in Salt and Salt-Free Aqueous Solutions',

submitted and under review.

Ruoshi Li; Donald L. Feke* 'Rheological Study of Polysaccharides in

Aqueous/Salt Solutions Subjected to Ultrasonic Fields', 2012 AIChE Fall Annual

Meeting, 2012.

Chunying Wu; Zhe Tang; Wenwei Fan; Wenxia Zhu; Changning Wang; Eduardo Somoza;

Norbert Owino; Ruoshi Li; Patrick Ma; Yanming Wang* "In Vivo PET Imaging of

Mesenchymal-Epithelial Transition (MET) Receptors," J. Med. Chem. 2010, 53,

139.

Y. Rong; R. Li; W. Lu 'Pd(II)-Catalyzed Coupling of p-Xylene via Regioselective

C-H Activation in TFA' Organometallics 2007, 26, 4376. (The Most-Accessed

Article in Jul -Sep of 2007)

R. Li; S. R. Wang; W. Lu 'FeCl3-Catalyzed Alkenylation of Simple Arenes with

Aryl-Substituted Alkynes' Org. Lett. 2007, 9, 2219.

R. Li; L. Jiang; W. Lu 'Intermolecular Cross-Coupling of Simple Arenes via C-H

Activation by Tuning Concentrations of Arenes and TFA' Organometallics 2006,

25, 5973. (The Most-Accessed Article in Oct -Dec of 2006)

Contact this candidate