Chunyan Wang, PhD

Polymer scientist using a variety of different polymerization methods to

develop multifunctional polymer composites with desired chemical and

physical properties for medical applications.

Seeking a challenging position with an active, forward-looking research

team to create, test and evaluate new polymers for marketable applications.

ADDRESS

University of South Florida

Morsani College of Medicine

Dept. of Molecular Medicine

12908 USF Health Drive

Tampa, FL 33612

accxam@r.postjobfree.com

813-***-**** (cell)

A. RESEARCH EXPERIENCE & QUALIFICATIONS

1. Analytical Techniques

I have more than five years experience in the practical use of advanced

analytical techniques including differential scanning calorimetry (DSC),

dynamic mechanical analysis (DMA), TGA, FTIR, Raman spectroscopy, HPLC,

GC/MS, GPC, NMR, scanning and transmission electron microscopy (SEM-EDXA),

confocal microscopy, live animal fluorescence imaging (Xenogen), spin

coating, spray drying, rheometry, potentiometry, and cyclic voltammetry.

2. Materials Chemistry

In my research projects over the past five years, I have designed, produced

and characterized a variety of natural and synthetic polymers including:

. Chitosan-functionalized mPEG-PLA (ring-opening polymerized) polymeric

nanoparticles for targeted in vivo co-delivery of nucleic acids, drugs

and MRI contrast agents using mouse model of human cancer

. Molecular imprinted polymeric nanoparticles for pH-activated drug

release

. Thermoactive polymeric nanoparticles for controlled, temperature-

inducible drug release

. Photocrosslinkable hydrogel coatings for implantable glucose sensors

. Injectable ROS (reactive oxygen species)-activated chitosan-PEG

hydrogel as stem cell carrier for regenerative medicine

. Small molecular weight polyacrylamide by precipitation polymerization

. Poly(acrylamide-co-styrene) by emulsion polymerization

. Cationic polyacrylamides using Hoffmann degradation of polyacrylamide

or poly(acrylamide-co-styrene)

3. In vitro / in vivo safety testing, pharmacokinetics and evaluation

. determine drug loading and release kinetics, cytotoxicity, cell uptake

and subcellular release of the formulation's payload in vitro

. measure the biodistribution, toxicity, and delivery efficiency of the

drugs and nucleic acids in various formulations in vivo (rodent

models)

. synthesize and characterize biocompatible polymer composites for

implantable biosensors and tissue engineering in vitro and in vivo.

B. EDUCATION & TRAINING

. 2013 - present. Research Associate, joint appointment in Dept. of

Internal Medicine and Nanomedicine Research Center, Morsani College of

Medicine, University of South Florida, Tampa, FL

. 2012 - present. Research Associate, Dept. of Molecular Medicine,

Morsani College of Medicine, University of South Florida, Tampa, FL

. 2010 - 2012. Postdoctoral Scholar, Dept. of Molecular Medicine,

Morsani College of Medicine, University of South Florida, Tampa, FL

. 2009 - 2010. Postdoctoral Scholar, Dept. of Mechanical Engineering,

University of Wisconsin-Milwaukee, Milwaukee, WI

. 2005 - 2008. Received Ph.D. in Polymer Chemistry and Physics,

Chemistry Department, University of South Florida, Tampa, FL

. 2000 - 2003. Received MSc in Polymer Chemistry and Physics, Fujian

Normal University, Fuzhou, Fujian, China.

. 1996 - 2000. BSc in Chemistry Education, Shandong Normal University,

Jinan, Shandong, China

C. TEACHING EXPERIENCE

. 2010 - present. Graduate student mentor in the Department of Molecular

Medicine, Morsani College of Medicine University of South Florida

. 2006 - 2008. Teaching assistant and tutor in Chemistry Department,

University of South Florida (Course: General Chemistry I & II Labs)

. 2006 - 2007. Undergraduate student mentor in the Department of

Chemistry, University of South Florida

D. HONORS

. Award of Excellence for best oral presentation at the 5th annual

Nanoscience Technology Symposium (September 2012), University of South

Florida

. Second place prize for oral presentation at the 6th annual Castle

Conference, University of South Florida (April 2008)

. First place prize for oral presentation at the 3rd annual Meeting in

Miniature of the Tampa Bay Section of the American Chemical Society

(March 2007)

. Fred L & Helen M Tharp Endowed Scholarship (summer 2007 and 2008)

E. PROFESSIONAL AFFILIATIONS

. American Chemical Society (ACS), member since 2008

. American Association for Cancer Research (AACR), member since 2011

. American Heart Association, since 2012

. Co-chair of the 6th Castle Conference, 2008

F. PUBLICATIONS

1. Chunyan Wang, Sowndharya Ravi, Jaya Mallela, Ryan Green, Micheal

Cheung, Shyam S. Mohapatra, Subhra Mohapatra, Enhancing the Mulitilineage

Differentiation of Bone Marrow Derived Mesenchymal Stem Cells in Three

Dimentional PEG-Chitosan-Graphene Based Hydrogel Matrix, prepared for

Tissue Engineering A

2. Mahasweta Das, Chunyan Wang, Raminder Bedi, Subhra Mohapatra and Shyam

Mohapatra, Chitosan-PEI-coated magnetic micelle nanoparticles deliver DNA

to rat brains after mild traumatic brain injury, Nanomedicine,

nanotechnology, biology and medicine, accepted, (IF=6.930)

3. Chunyan Wang, Sowndharya Ravi, Ujjwala Sree Garapati, Mahasweta Das,

Mark Howell, Jaya Mallela, Subbiah Alwarappan, Shyam S. Mohapatra and

Subhra Mohapatra, Multifunctional chitosan magnetic-graphene (CMG)

nanoparticles: a theranostic platform for tumor-targeted co-delivery of

drugs, genes and MRI contrast agents, Journal of Material Chemistry B,

2013, 1, 4396-4405 (IF=6.101)

4. Chunyan Wang, Vignesh Chinnasamy, Ujjwala Sree Garapati, Sowndharya

Ravi, Jaya Mallela, Yvonne Davis, Subhra Mohapatra, A Chitosan-Modified

Graphene Nanogel (CGN) for Noninvasive Controlled Drug Release,

Nanomedicine, nanotechnology, biology and medicine, 2013, 9 (7), 903-11

(IF=6.930)

5. Chunyan Wang, Jaya Mallela, Subhra Mohapatra, Pharmacokinetics of

polymeric micelles for cancer treatment, Current Drug Metabolism, 2013, 14

(8), 900-909 (IF=4.9)

6. Yvonne K. Girard, Chunyan Wang, Sowndharya Ravi, Mark C. Howell, Jaya

Mallela, Mahmoud Alibrahim, Ryan Green, Gary Hellermann, Shyam Mohapatra,

Subhra Mohapatra, A 3D fibrous scaffold inducing tumoroids: a platform for

anticancer drug development, PLOS ONE, in press, (IF=3.73)

7. Howell M, Wang C, Mahmoud A, Hellermann G, Mohapatra SS and Mohapatra S,

Dual-function theranostic nanoparticles for drug delivery and medical

imaging contrast: perspectives and challenges for use in lung diseases,

Drug Delivery and Translational Research, 2013, 3(4), 352-363

8. J. Devkota, C. Wang, A. Ruiz, S. Mohapatra, P. Mukherjee, H. Srikanth,

M.H. Phan, Detection of low-concentration superparamagnetic nanoparticles

using an integrated RF magnetic biosensor, Journal of Applied Physics,

vol.113, 2013, 104***-****** (IF=2.21)

9. Jaya Mallela, Frantz Jean Louis, Shyam S. Mohapatra, Sowndharya Ravi,

Bianca Mulaney, Michael Cheung, Ujjwala Sree Garapati, Vignesh Chinnasamy,

Srinivas Nagaraj, Chunyan Wang, Subhra Mohapatra, Natriuretic Peptide

Receptor-A Signaling Regulates Stem Cell Recruitment during Angiogenesis,

Stem Cells, 2013, 31(7), 1321-1329 (IF= 7.701)

10. Chunyan Wang, Sowndharya Ravi, Gary V. Martinez, Vignesh Chinnasamy,

Payal Raulji, Mark Howell, Yvonne Davis, Mohindar S. Seehra, Subhra

Mohapatra, Dual-purpose Magnetic Micelle Nanoparticles for MRI and Gene

Delivery, Journal of Controlled Release, 2012, 163 (1), 82-92 (IF=7.633)

11. Mark Howell, Jaya Mallela, Chunyan Wang, Sowndharya Ravi, Ujjwala Sree

Garapati,

Subhra Mohapatra, Manganese-loaded Lipid-Micellar Theranostics for

Simultaneous Drug and Gene Delivery to Lungs, Journal of Controlled

Release, 2012, 167(2), 210-218 (IF=7.633)

12. Chunyan Wang, Mark Howell, Payal Raulji, Yvonne Davis, Subhra

Mohapatra, Preparation and Characterization of Molecularly Imprinted

Polymeric Nanoparticles for Modulating NPRA (natriuretic peptide receptor

A), Advanced functional materials, 2011, 21(23):4423-4429, (IF=9.765)

13. Chunyan Wang, Javadi, Alireza; Ghaffari, Mehdi; Gong, Shaoqin, A pH-

Sensitive Molecularly Imprinted Nanospheres/Hydrogel Composite as a

Potential Coating Material for Implantable Biosensors, Biomaterials, 2010,

31(18):4944-51 (IF=7.604)

14. Chunyan Wang, Bazhang Yu, Bernard Knudsen, Julie Harmon, Francis

Moussy, Yvonne Moussy, Synthesis and Performance of Novel Hydrogel Coatings

for Implantable Glucose Sensors,Biomacromolecules, 2008, Vol.9, No.2, P561-

567 (IF= 5.371)

15. Bazhang Yu, Chunyan Wang, Young Min Ju, Leigh West, Julie Harmon,

Yvonne Moussy, Francis Moussy, Use of Hydrogel Coating to Improve the

Performance of Implanted Glucose Sensors, Biosensors and Bioelectronics,

2008, Vol. 23, No. 8, P1278-1284 (IF=5.437)

16. Zonghua Wu, Shaoping Chen, Chunyan Wang, Preparation of Cationic

Polyacrylamide Emulsion, Transactions of China Pulp and Paper, 2005, 20(2),

130-133

17. Chunyan Wang, Zonghua Wu, Effect of Molecular Weights of

Polyacrylamides on Its Hofmann Reaction, Chinese Journal of Applied

Chemistry, 2003, 20(8), 803-805

18. Chunyan Wang, Zonghua Wu, The Synthesis of the Low-molecular-weight

Polyacrylamide by Precipitation Polymerization, Journal of Fujian Normal

University (Natural Science Edition), 2002, 18(4), 61-63

19. Zonghua Wu, Chunyan Wang, Stability of Neutral Rosin Sizing Agents,

Paper Chemicals, 2002, 14(1), 12-13

20. Chunyan Wang, Yangyang Zhang. Preparation of glucosamine sulfate

method. Oceanic Industry of China, 2005

G. BOOK CHAPTERS

1. Chunyan Wang, Minghui Yang, Zhiyong Qian, Li He,Biocompatible

Nanocomposites for Bone Tissue Engineering, Recent Developments in Bio-

Nanocomposites for Biomedical Applications, Nova Science Publisher, 2011

2. Chunyan Wang, Bernard Knudsen, Xueji Zhang, Semiconductor Quantum Dots

for Electrochemical Biosensor, Biosensor Nanomaterials, Wiley-VCH

Publisher, 2011

3. Chunyan Wang, Bernard Knudsen, Xueji Zhang, Nanostructure for Nitric

Oxide Electrochemical Sensing, NanoBiosensing--Principles, Development and

Application, Springer Publisher, 2011

H. Patents

1. Subhra Mohapatra, Chunyan Wang, Multilayer magnetic micelle compositions

and methods for their use, WO2013049531 A2

2. Subhra Mohapatra, Chunyan Wang, Molecularly Imprinted Polymers Having

Affinity for Natriuretic Peptides, WO 201-***-**** A1

3. Subhra Mohapatra, Shyam S. Mohapatra, Yvonne Kathleen Davis, and Chunyan

Wang, Construction of the Multilayered Nanofiber (MN) and Chitosan

Multilayered Nanofiber (CMN) Scaffolds, Application No. 61/723,922

4. Subhra Mohapatra, Shyam S. Mohapatra, Mahasweta Das, Chunyan Wang,

Multilayered multifunctional magnetic micelle nanoparticles for delivery of

DNA to brains of rats with mild traumatic brain injury, No. 13/773,718

5. Subhra Mohapatra, Shyam S. Mohapatra, Mark Christian Howell, Suraj

Kishore Dixit, and Chunyan Wang, Micelle Compositions and Methods for Their

Use; No. 61/602,384

6. Subhra Mohapatra and Chunyan Wang, Noninvasive Remote-Controlled Release

of Drugs from a Nanogel Triggered by Near IR, No. 61/602,378

7. Subhra Mohapatra and Chunyan Wang, Graphene Hydrogels and Methods for

Using the Same, No. 13/775,560

8. Subhra Mohapatra and Chunyan Wang, Graphene-Based Theranostics for Tumor

Targeted Drug/Gene Delivery and Imaging, No. 61/767,572

I. CONFERENCE PRESENTATIONS

Invited Oral Presentations

1. Chunyan Wang, Bazhang Yu, Bernard Knudsen, Francis Moussy, Julie Harmon,

Design and Testing of Implanted Glucose Sensors with Novel Hydrogel

Coatings, The 84th Annual Florida Meeting and Exposition, ACS, Orlando, May

2008

2. Chunyan Wang, Development of Novel Biocompatible Hydrogel Coatings for

Implantable Glucose Sensors, C3B Consortium Lecture Series, Center for

Bioelectronics, Biosensors and Biochips, Advanced Materials Center, 100

Technology Drive, Anderson, SC, Department of Bioengineering and Department

of Chemical and Biomolecular Engineering, Clemson University, SC, March

2009

3. Chunyan Wang, pH Sensitive Biomimetic Nanospheres for Drug Delivery &

Biocompatible Hydrogel Coating for Implantable Biosensor, Department of

Molecular Medicine, Nanomedicine Center, University of South Florida, FL,

April, 2010

Oral Presentations

1. Chunyan Wang, Bazhang Yu, Bernard Knudsen, Francis Moussy, Julie Harmon,

Preparation of novel hydrogels coatings for implantable glucose sensors,

The 3rd annual Meeting in Miniature, Tampa, Florida, March 2007

2. Chunyan Wang, Bazhang Yu, Francis Moussy, Julie Harmon,The Effect of 2,3-

dihydroxypropyl methacrylate (DHPMA) on the Release Rate of Dexamethasone

21- phosphate disodium from Hydrogels, 3nd Annual Interdisciplinary

Graduate Student Symposium, University of South Florida, Tampa, FL, April

13, 2007

3. Chunyan Wang, Bazhang Yu, Julie Harmon, Francis Moussy, Yvonne

Moussy,Preparation of Novel Drug Delivery Vehicles for Implantable Glucose

Sensors, The 83rd Annual Florida Meeting and Exposition, ACS, Orlando, May

2007

4. Chunyan Wang, Bazhang Yu, Shisi Liu, Bernard Knudsen, Yvonne Moussy,

Julie Harmon, Francis Moussy,The in vitro and in vivo Evaluation of

Implanted Glucose Sensors with Hydrogel Coatings, 6th Castle conference,

University of South Florida, April 2008

5. Chunyan Wang, Sowndharya Ravi, Gary V. Martinez, Vignesh Chinnasamy,

Payal Raulji, Mark Howell, Yvonne Davis, Mohindar S. Seehra, Subhra

Mohapatra, Multilayered Multifunctional Magnetic Micelles Nanoparticles (4M-

NPs) for MRI and Gene Delivery, NanoBio Collaborative International

Conference, Mar. 28, 2012, Tampa, FL

6. Chunyan Wang, Vignesh Chinnasamy, Sowndharya Ravi, Jaya Mallela, Yvonne

Girard, Mark Howell, Subhra Mohapatra, A Thermosensitive Graphene Nanogel

(TGN) for Noninvasive Controlled Drug Release, NanoFlorida, Sept. 29, 2012,

Tampa, FL

Poster Presentations

1. Chunyan Wang, Bazhang Yu, Shisi Liu, Bernard Knudsen, Julie Harmon,

Francis Moussy, Yvonne Moussy,The Effect of N-vinyl-2-pyrrolidinone (NVP)

on the Release Rate of Dexamethasone 21-phosphate disodium (DX-21) from

Hydrogels, FCoE-BITT, University of South Florida, October 24, 2007

2. Chunyan Wang, Bazhang Yu, Julie Harmon, Francis Moussy, Effect of

Hydrogels Composition on the Drug Release, FCoE-BITT, University of South

Florida, October 15, 2008

3. Chunyan Wang, Mark Howell, Payal Raulji, Yvonne Davis, Subhra Mohapatra,

Molecularly Imprinted Polymeric Nanoparticles for Atrial Natriuretic

Peptide (ANP) to Modulate Cancer, Research Day, Feb., 2011, University of

South Florida, Tampa, FL,

4. Chunyan Wang, Mark Howell, Payal Raulji, Yvonne Davis, Subhra Mohapatra,

Molecularly Imprinted Polymeric Nanoparticles for Atrial Natriuretic

Peptide (ANP), NanoDDS '11, October 15-16, 2011, Salt Lake City, Utah, USA

5. Chunyan Wang, Sowndharya Ravi, Gary V. Martinez, Vignesh Chinnasamy,

Payal Raulji, Mark Howell, Yvonne Davis, Mohindar S. Seehra, Subhra

Mohapatra, Multilayered Multifunctional Magnetic Micelle Nanoparticles (4M-

NPs) for MRI and Gene Delivery, Research Day, Feb., 2012, University of

South Florida, Tampa, FL

6. Chunyan Wang, Vignesh Chinnasamy, Subhra Mohapatra, Noninvasive Remote-

Controlled Release of Drugs from a Nanogel Triggered by Near IR, Research

Day, Feb., 2012, University of South Florida, Tampa, FL

7. Chunyan Wang, Vignesh Chinnasamy, Subhra Mohapatra, Noninvasive Remote-

Controlled Release of Drugs from a Nanogel Triggered by Near IR, NanoBio

Collaborative International Conference, Mar. 28, 2012, Tampa, FL

8. Chunyan Wang, Sowndharya Ravi, Ujjwala Sree Garapati, Mahasweta Das,

Jaya Mallela and Subhra Mohapatra, Multifunctional Chitosan Magnetic-

Graphene Nanoparticles (CMGs): a Theranostic Platform for Tumor-targeted Co-

delivery of Drug, Gene and MRI Contrast Agent, University of South Florida

Research Day, Feb.22, 2013, Tampa, FL

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