Tariq Adwan * of *

Tariq S. Adwan

*** ****** **, ********, ** 18509. accu9r@r.postjobfree.com. 570-***-****

Education:

University of Colorado Denver, Aurora, CO 80045, USA

Ph.D. Cell Biology, Stem Cells and Development Program. 08/11.

Thesis lab: Dr. Mary Reyland’s Lab, Department of Craniofacial Biology.

GPA: 3.87/4.00.

Misericordia University, Dallas, PA 18612, USA

B.S. Major: Biology; Minor: Chemistry. 05/05.

GPA: 3.66/4.00.

Language Skills: Fluent in written and spoken Arabic.

Research Experience:

• Craniofacial Biology Department, University of Colorado Denver, Aurora, CO. 07/06-08/11.

Ph.D. Thesis dissertation project. Advisor: Dr. Mary Reyland.

o Thesis title: Remodeling of Inter- and Intra-Molecular Interactions: A Mechanism for Nuclear

Import of PKCδ.

o Evaluated the role of tyrosine phosphorylation in regulating nuclear import of PKCδ and apoptosis.

o Defined a novel mechanism that retains PKCδ in the cytoplasm of resting cells and regulates its

nuclear import in response to apoptotic stimuli.

• Biology Department, Misericordia University, Dallas, PA. 09/04-05/05.

Research Assistant. Supervisor: Dr. Angela Asirvatham.

o Explored the role of A-Kinase Anchoring proteins (AKAPs) in heregulin-stimulated proliferation of

Schwann cells.

o Confirmed the presence of AKAP-95 in Schwann cells and showed that AKAP-95 localizes to the

nucleus in response to heregulin treatment.

• Orthopedic Surgery Department, Thomas Jefferson University, Philadelphia, PA. 06/04-08/04

Summer Research Fellow. Supervisor: Dr. Vickram Srinivas.

o Explored the effects of hypoxia on Trail-induced apoptosis in U2OS Osteosarcoma cells.

o Showed that hypoxia decreases the efficiency of Trail-Induced apoptosis.

• Chemistry Department, Misericordia University, Dallas, PA. 05/03-05/04

Research Assistant. Supervisor: Dr. Larry Pedersen.

o Screened medicinal plants, collected during a trip to Nicaragua, for cytotoxic compounds with the

goal of identifying anticancer agents.

o Extracted the leaves, fractionated the extracts using column chromatography and measured the LD50

of the various fractions using Brine Shrimp assay.

• Israeli Aerospace Medical Institute, Tel Aviv, Israel/Planetary Society, Pasadena, CA. 12/02-05/03

Co-Investigator. Supervisor: Dr. Iran Shenkar and Dr. David Warmflash.

o Participated in designing and preparing the experiment aimed at studying the formation of thin layer

of microbial cells on inorganic crystalline surfaces, in the weightless and radiation-intensive

conditions that prevail in space.

o The experiment orbited the earth on board the ill-fated STS-107 Columbia Shuttle.

Tariq Adwan 2 of 3

Biology Department, Bethlehem University, Bethlehem, West-Bank. 06/03-08/03

•

Research Assistant. Supervisor: Dr. Moien Kanaan.

o Explored the contribution of Connexin-26 (GJB2) deletion mutation to hearing loss in a deaf

Palestinian population’s sample.

o Showed that GJB2 deletion mutation contributed to hearing loss in 11% of the sample population.

Research Techniques:

• Molecular Biology: Subcloning and plasmid construction, site directed mutagenesis, PCR and primer

design, transient transfection (FuGene6 and Lipofectamine), bacterial cell transformation, luciferase

reporter assay, protein purification, GST-pull down, co-immunoprecipitation, Western blot, protein

kinase activity assay, zymogen assay, protein arrays, protein and DNA gels, and chromatography.

• Cell Biology: Aseptic technique, bacterial cell culture and selection methods, cell lines/primary cell

culture, cellular apoptosis assays (MTT and TUNEL), immuno-fluorescent staining/microscopy, flow

cytometry, cell migration and invasion, subcellular fractionation, and Brine Shrimp assay.

• In Vivo Animal Handling: Mouse injections, surgery and isolation of primary cells.

Awards, Honors and Grants:

• Recipient, National Research Service Award, Pre-doctoral Fellowship, NIDCR/NIH, 02/09-08/11.

• 1st place, Best Poster Award, Cell and Developmental Biology Retreat, 09/07.

• Recipient, Misericordia University Board of Trusties Award. Annually awarded to one student

exemplifying the College’s academic, leadership and service ideals, 05/05.

• Recipient, Judith Ellis Academic Scholarship, 09/03-05/05.

• Dean’s list, Misericordia University, 01-03.

• Recipient, Sisters of Mercy Peace Scholarship, awarded for proven leadership skills and an outstanding

record of peace building activities. 09/02-05/05.

• Recipient, McAuley Award Given by Misericordia University for an outstanding service and

leadership record. 09/01-05/05.

Work Experience:

• Faculty of Medicine, An-Najah National University, Nablus, West bank. 08/12-08/13.

Assistant Professor.

o Courses taught: Cell Biology, Biochemistry, and Clinical Biochemistry with lab.

• Craniofacial Biology Department, University of Colorado Denver, Aurora, CO. 10/11-08/12.

Post-Doctoral fellow. Advisor: Dr. Mary Reyland.

o Deciphering the mechanisms by which PKCδ is activated in response to apoptotic stimuli.

o Performing functional assays to identify tyrosine kinases that phosphorylate PKCδ in apoptotic cells.

o Using subcellular localization techniques to track where PKCδ localizes in apoptotic cells.

• Continuing Education Department, Misericordia University, Dallas, PA. 05/02-07/05.

Conference Staff. Supervisor: Theresa Hollock.

o Worked as a conference staff in charge of preparing conference rooms and managing A/V equipment

to ensure conference sessions went uninterrupted.

o Worked as a receptionist at the guesthouse.

o Transported conference guests to their destinations on/off campus, and served as their tour guide on

campus tours and surrounding area.

Publications:

• Tariq S. Adwan, Angela M. Ohm, David N.M. Jones, Michael J. Humphries and Mary E. Reyland.

Regulated Binding of Importin-α to PKCδ in response to Apoptotic Signals Facilitates Nuclear Import.

J Biol Chem (2011) 286, 357**-*****.

• Michael J. Humphries, Angela M. Ohm, Jerome Schaack, Tariq S. Adwan and Mary Reyland. Tyrosine

Phosphorylation In The Regulatory Domain Of PKCδ Controls Nuclear Localization And Apoptosis.

Oncogene (2008) 27, 3045–3053.

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“My Responsibility”, an essay Published in “The Interdependence Handbook” page 62. Edited by Sondra

•

Myers and Benjamin R. Barber. Published in 2004 by The International Debate Education Association, 400 West 59th

Street, New York, NY 10019.

Posters and Presentations:

• Tariq Adwan and Mary Reyland. Invited Speaker: Remolding Of Molecular Interactions: A

Mechanism For Nuclear Import Of PKCδ. FASEB Conference. Steamboat, CO 07/12.

• Tariq Adwan and Mary Reyland. Poster presented: C-terminal Proline-Rich Motif: A Potential Role in

Tyrosine Phosphorylation and Nuclear Import of PKCδ. FASEB Conference. Carefree, AZ 07/09.

• Tariq Adwan and Mary Reyland. Poster Presented: The Role of A C-Terminal Proline –Rich Motif in

Tyrosine Phosphorylation and Nuclear Import of PKCδ. American Association for Cancer Research

100th Annual Meeting. Denver, CO 04/09.

• Tariq Adwan and Mary Reyland. Poster presented: PKCδ: An Important Regulator of Salivary Gland

Apoptosis. 25th Annual Dental Research Day. Aurora, CO 02/09.

• Tariq Adwan and Mary Reyland. Poster presented: The Mechanism Regulating Nuclear Translocation

of PKCδ in Salivary Acinar Cells. Gordon Research Conference. Galveston, TX 02/09.

• Tariq Adwan and Mary Reyland. Poster Presented: Tyrosine Phosphorylation Regulates Nuclear

Localization of PKCδ. FASEB conference. Palm Springs, CA, 08/07.

• Tariq Adwan and Larry Pedersen. Poster Presented: Phytochemical Analysis Of Weldelia Trilobata.

227th National Meeting of the American Chemical Society. Anaheim, CA, 03/04.

Leadership Activities:

• Organizer, Cell Biology, Stem Cells and Development Program Annual Retreat. 01/09-09/09.

• Organizer, “A Vision for the Future of the Health Sciences: From Independence to Interdependence”.

01/09-09/09.

• Member, Admissions Committee, Cell Biology, Stem cells and Development Program. 12/08-12/09.

• Organizer, Cell Biology, Stem Cells and Development Program Student Run Journal Club 09/08-09/09.

• Vice President of Diversity, University of Colorado Student Senate. 04/08-04/08.

• Senator, University of Colorado, Student Senate. 09/06-09/08.

• Resident/Member, Misericordia University Leadership House. 09/04-05/05.

• Participant, “Diversity Student Leadership”. Wilkes-Barre, PA. 12/01.

• President, Misericordia University Pre-Med Club. 09/03-05/05.

• Guest Speaker, "Democracy in the 21st Century", Misericordia University, Dallas, PA 05/03.

• Guest Speaker, “Palestinian Israeli Conflict” Jewish Community Center, Asbury Park, NJ 06/02.

• Participant, Intercollegiate Leadership, Wilkes-Barre, PA. 01/02-05/02.

References:

Dr. Mary E. Reyland

Cancer Biology Program, Director

University Of Colorado Anschutz Medical Campus

Phone: 303-***-****. E-mail: accu9r@r.postjobfree.com

Dr. Steve M. Anderson

Department of Pathology, Vice Chair for Research

University Of Colorado Anschutz Medical Campus

Phone: 303-***-****. E-mail: accu9r@r.postjobfree.com

Dr. David N. Jones

Department of Pharmacology, Professor

University Of Colorado Anschutz Medical Campus

Phone: 303-***-****. E-mail: accu9r@r.postjobfree.com

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