Uma Kotipalli

** ******* ****

Brantford, ON N*T 0H1

Phone : 519 - 304 - 1624, Cell: 519 - 771

- 1425

Email: acc5xk@r.postjobfree.com

OBJECTIVE

To utilize my education, knowledge and experience in the chemical industry

and contribute as a " Chemist-II"

EDUCATION

M.Sc. (Industrial Chemistry) 1997

Andhra University, India

B.Sc. (Chemistry, Physics, Mathematics)

1995

Andhra University, India

SUMMARY OF SKILLS

> Highly motivated process R&D chemist, with more than 17 years

experience in industry at reputed organizations.

> Proven skills in synthesis and process development of APIs.

> Strong analytical interpretation capability, in NMR, LC-MS, HR-MS, GC-

MS, UV-VIS and IR

> Collected extensive literature of new molecules from websites and

scientific databases and search engines.

> Quality control analysis related to research and development

experiments including TLC, Preparative HPLC, moisture content, melting

range and determined product specification

> In-depth experience of safe handling all toxic and corrosive chemicals

> Successfully conducted laboratory experiments to manufacture API, and

delivered the compounds to support further studies / technology

transfer

> Familiar with cGMPs, ICH guidelines and ensured compliance with all

applicable regulation and SOPs

> Evaluated impurity profile of approved pharmaceutical ingredients,

chemical process technology and equipment

> Maintained lab documentation as per GLP and FDA Guidelines

> Hands on experience for the Active Pharmaceutical Ingredients of

ROSUVASTATIN CALCIUM, ATROVASTATIV CALCIUM PG SOLVATE, LUBIPROSTONE,

NILOTINIB HCl, VILAZODONE HCl BEZOATE SOLAVTE, RUFINAMIDE, PAROXETINE

MESYLATE, MONTELUKAST SODIUM, PANTAPRAZOLE, LAMIVUDINE, LORATADINE,

MIRTAZAPINE, PIOGLITAZONE, ALFUZOSIN, VENLAFAXINE HCl, CELECOXIB and

multiple steps of Cancer therapeutic drugs and intermediates.

> Hands on experience the Synthetic Reactions of Grignard, Aldol, Swern

Oxidation, Wittig, Suzuki Coupling, Buchwald Coupling, Silylation,

Chlorination, Bromination, Mesylation, Selective Reductions,

Oxidation, Protection, Deprotection, Benzylation, Esterification,

Hydrolysis, Acetylation, Methylation, and Cyanation etc

> Knowledge of purification techniques by using different solvents and

chromatography separation of compounds by using ordinary and pressure

columns

> Prepared and reviewed product labeling, batch records, specification

sheets, and test methods for compliance with applicable regulations

and policies for both in-house and vendor samples

> Maintained documents, lab note books, analytical results and SOPs

> Prepared documents related to process development like, reference

standard reports, process development reports, process flow diagrams

etc

> Prepared presentation for meetings. Posses good written and oral

communication skills

> Evaluated impurity profile of approved pharmaceutical ingredients,

chemical process technology and equipment

> Developed and modified laboratory exercised to satisfy safety and

pollution inspections

> Knowledge of MS Office, higher speed typing certification, Chem draw,

ACD Chem sketch, ISIS MDL draw

EMPLOYMENT HISTORY

Chemist-I R&D: APOTEX Pharmachem Inc, Brantford, ON, Canada 2006 -

Present

(8 years)

Research Technician: LORUS Therapeutics Inc, Toronto, ON, Canada 2005 -

2006

(8 months)

Scientist: BIOCON Limited, Banagalore, India

2002 - 2005

(2 years 10 months)

Research Executive: CIPLA Limited, Banagalore, India

2001 - 2002

(1 year 3 months)

Assistant Officer R&D: MATRIX Laboratory Limited, India

1997 - 2001

(3 years 9 months)

PATENTS AND PUBLICATIONS

1) ATORVASTATIN Calcium Propylene Glycol Solvate prepared from Racemic

Propylene Glycol:

United States Patent US 7,834,195,B2 Issued: Nov16, 2010

2) Methods of Making LUBIPROSTONE and Intermediates thereof:

USPTO Application #201******** Issued: 03/15/12

3) More efficient Palladium Catalyst for Hydrogenolysis of Benzyl Groups:

Synthetic Communications, 36: 925-928, 2006 (Prasad Subramaniam)

REFERENCES AVAILABLE UPON REQUEST

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