Miss. Gitanjeli Prasad, Ph.D.

*** **** ******, *** ***, Cambridge, MA, 02141

Phone: 413-***-****

aca71n@r.postjobfree.com

CAREER PROFILE

Chemistry professional with cross functional expertise in organic, bio-analytical techniques and hands-on experience in Chemistry and Manufacture Controls (CMC) in pharmaceutical industry.

EDUCATION

University of Massachusetts Amherst Aug 2008-May 2013

Ph.D., Department of Chemistry

Thesis title: Reactive heterocycles for investigating mechanisms of polyketide biosynthesis

Institute of Chemical Technology, Mumbai Sept 2003-May 2007

Bachelor of Technology, Department of Dyestuff and Intermediates

SUMMARY OF SKILLS

Expertise in use of LC/MS, U/HPLC, Prep LC, SDS-PAGE, SEC, CE, NMR, UV/Vis, GC, FT-IR for

purification, characterization and analysis of small molecules, proteins and peptides

Proficient in analytical method development for small molecules and proteins/peptides

Analytical method validation for HPLC and LC-MS methods

Small molecule synthesis and organic chemistry principles

Chemistry and Manufacturing Controls (CMC)documentation and regulatory affairs

Experienced in using instrumentation of Waters Empower, Shimadzu, Chromatography Data Software

(CDS), ACD Labs NMR software, MS Office, ChemDraw software

WORK EXPERIENCE

Post-Doctoral Scientist, Chemistry and Manufacture Controls (CMC) - Boston Biomedical Inc., Cambridge,

MA

June 2013-present

Extensive use of HPLC, Mass spectrometry, UV/Vis spectroscopy to perform testing of materials for

analytical compliance of quality to support manufacturing activities

Analytical method development and method validation for Active Pharmaceutical Ingredients, drug

products, impurities, in-process materials etc. in compliance with cGLP practices

Analytical testing of samples for solubility, dissolution profile, stability, impurity profiling and chemical

development activities

Working closely with Contract Research Organizations (CRO) and Contract Manufacturing Organizations

(CMO) to assist with in-house R&D efforts and upto commercial scale manufacturing

Manage CMC aspect documentation and timeline of GMP manufacturing activities

Perform extensive documentations of drug in clinical development including drafting, reviewing and

updating of SOPs, validation protocols, batch records, and QA reports

Work on CMC related document preparation and submission for regulatory authorities

Gitanjeli Prasad Resume

Doctoral Dissertation Aug 2008-May 2013

Developed series of novel small molecules for site-specific labeling of polyketide synthases

Extensive use of HPLC and Mass spectrometry for bio-analytical analysis of labeled polyketide synthase

proteins

Designed a novel mechanism-based ex-vivo fluorescence assay for mechanistic interrogation of key

enzymatic steps in polyketide biosynthesis. Demonstrated that this technique provides a simple,

reproducible and visual platform for functional analysis of enzymatic events

Performed extensive analytical method development to enhance sensitivity and resolution on LC/MS

to observe large proteins and peptides

Used mass spectrometry to perform structural and functional analysis of newly sequenced Fluvirucin B1

synthase proteins

Utilized and optimized SDS-PAGE, SEC, FPLC, dialysis techniques for purification and separation of PKS

protein complexes

Technical Promoter of Dyes and Textile Auxiliaries -Huntsman International June 2007- June 2008

Specialized in troubleshooting with latest Colorimetric instruments in laboratory

Collaborated with diverse and multi-ethnic teams of Research/Applications and Marketing to explore

new strategies for product development

Pioneered and implemented project ‘Innovation’ for ‘Change Management’ with Human Resources and

Marketing. Achieved 5 % increase in sales by revolutionizing company strategies across all departments

Summer Intern - Clariant Chemicals May 2006- July 2006

Worked in Process Chemistry division. Scaling up synthetic routes efficiently in pilot plant for dyes and

intermediates

Trained in other departments such as Quality Control, Production, EH&S and Effluent Treatment

PUBLICATIONS

Prasad, G., Borketey, L.S., Lin, T., Schnarr, N.A., ‘A Mechanism-Based Fluorescence Transfer Assay for

Examining Ketosynthase Selectivity’. Org. Biomol. Chem, 2012, 10, 6717-6723

Prasad, G., Amoroso, J. W., Borketey, L. S., Schnarr, N. A., ‘N-Activated β-Lactams as Versatile Reagents

for Acyl Carrier Protein Labeling’. Org. Biomol. Chem, 2012, 10, 1992-2002

Amoroso, J. W., Borketey, L. S., Prasad, G., and Schnarr, N. A., ‘Direct Acylation of Carrier Proteins with

Functionalized β-Lactones’. Org. Lett., 2010, 12, 2330-233

Lin, T., Borketey, L. S., Prasad, G., Waters, S. A., and Schnarr, N. A. ‘Sequence, cloning, and analysis of

the fluvirucin B1 polyketide synthase from actinomadura vulgaris’. ACS Synth. Biol. 2013

PRESENTATIONS AND AWARDS

Represented UMass Amherst with oral presentation at Chemical Biology Interface (CBI) Joint Retreat,

Amherst, June 2012.

Selected and presented oral presentation titled, ‘Reactive Heterocycles for investigating mechanisms of

Polyketide Biosynthesis’ at Graduate Research Symposium, ACS-Organic Division, Boulder, CO. July

2012.

Poster presentation at ACS Boston (2011) titled, ‘Tunable acyl carrier protein acylation with N-

protected β-lactams’

William E. McEwen Fellowship Award for Outstanding Poster presentation, 2012

William E. McEwen Fellowship Award for Outstanding Poster presentation, 2011

Gitanjeli Prasad Resume

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