Jay P. Patel
**-** ****** ******, ****** Village, NY 11427, 614-***-****, aca1y4@r.postjobfree.com
Residential Status: Permanent Resident (Green card)
Professional Goal
To take a stimulating, innovative and leadership role to excel in the field of chemistry, and to implement the expertise and proficiency gained to develop novel molecules.
Education
Ph.D. Medicinal/Organic Chemistry
St. John’s University, New York, Jan. 2009-May 2013
Advisor: Dr. Vijaya L. Korlipara
Research project: Design, synthesis and biological evaluation of bioisosteric analogues of
dasatinib as Src, Bcr/Abl and Abl T315I protein tyrosine kinase inhibitors.
MS Medicinal/Organic Chemistry
St. John’s University, New York, Jan. 2006-Dec. 2008
Advisor: Dr. Vijaya L. Korlipara
Research project: Design, synthesis and biological evaluation of OSI-930 analogues as dual
inhibitors of c-kit and KDR tyrosine kinase.
Bachelor of Pharmacy
Gujarat University, India, June 2001-May 2005
Professional Experience
Assistant Professor of Chemistry (Part-time), St. John’s University, New York (Sept. 2013-
Present)
Ø Instructor for General Chemistry, Organic Chemistry, Biochemistry, Medicinal Chemistry
and Biomedical courses for undergraduate Pharm. D. students
Ø Prepared and presented lectures for respective courses as well as conducted and evaluated
quizzes and final examinations for students
Ø Successfully learned and applied concept of Process Oriented Guided Inquiry Learning
(POGIL) while conducting recitation sections with undergraduate students
Doctoral Researcher, St. John’s University, New York (Jan 2009-May 2013)
Ø Accomplished extensive research in oncology drug discovery through SAR studies and lead
optimization
Ø Successfully performed complex organic synthesis through method development, route
selection and route optimization
Ø Efficiently characterized small and large molecules using modern analytical techniques
Ø Developed and optimized in vitro assays to evaluate biological activity of anti-cancer agents
Ø Effectively established protocol for in vivo assays and conducted assays to determine
hypoglycemic effects of compounds synthesized in laboratory
Ø Manuscript writing for publication and poster presentation for scientific conferences
Student/Internship, Astellas Pharma US, Inc. (May 2006-Aug 2009)
Ø Developed a novel system for reductive amination reactions
Ø Worked on improvement of yields through variety of reductive amination reactions
Ø Process discovery, development and optimization
Ø Proposed and developed analogues of OSI-930 to improve its pharmacokinetic profile
through application of medicinal chemistry strategies
Ø Presentation of data to scientists at OSI on bi-weekly basis
Professional/Laboratory Skills
Chemistry
• Hands-on experience in multistep complex organic synthesis, structure based and fragment based
drug design, affinity probes, and high speed analoging chemistry
• Detailed and up-to-date knowledge of current organic chemistry synthesis techniques
Analytical
• Skilled in isolation and characterization of bioactive compounds using analytical techniques such as flash column chromatography, HPLC, LC/MS/MS, GC-MS, FT- IR and NMR
• Expert in collecting, analyzing and interpretation of data as well as effective troubleshooting skill
Computational
• Comprehensive knowledge of computational chemistry
• Structure based drug design using Glide Docking, Induced Fit Docking, and Virtual Screening
Biology
• Experienced in conducting in vitro and in vivo studies
• Hand-on experience in cell culturing and bioassay techniques such as MTT assay, XTT assay,Z’LYTE assay, ELISA and DNA gel electrophoresis
Personal/Professional
• Proven record in scientific writing of manuscripts and poster presentations
• Effective working individually, in a team, or collaborating with outside groups
• Excellent interpersonal, analytical and problem solving skills
Publications
Jay Patel, Zhe-Sheng Chen, Vijaya L. Korlipara; Design, synthesis and biological evaluation of bioisosteric analogues of dasatinib as Src, Bcr/Abl and Abl T315I protein tyrosine kinase inhibitors. (Submitted to J. Med. Chem.)
Ye-Hong Kuang, Jay P. Patel, Vijaya L. Korlipara, Zhe-Sheng Chen; OSI-930 analogues as
novel reversal agents for ABCG2-mediated multidrug resistance. Biochemical Pharmacology, 84(2012), 766-774.
Jay Patel, Ye-Hong Kuang, Zhe-Sheng Chen, Vijaya L. Korlipara; Inhibition of c-Kit, VEGFR-
2 (KDR), and ABCG2 by analogues of OSI-930. Bioorganic & Medicinal Chemistry Letters, 21(2011), 6495–6499.
Jay Patel, An-Hu Li, Hanquing Dong, Mark J. Mulvihill, Vijaya L. Korlipara;
Polymethylhydrosiloxane (PMHS)/Trifluoroacetic acid (TFA):A novel system for reductive
amination reactions. Tetrahedron Letters, 50 (2009), 5975-5977.
Poster Presentations
Jay Patel, Ye-Hong Kuang, Vijaya L Korlipara, Zhe-Sheng Chen; Analogues of OSI-930 as
potent ABCG2-mediated multidrug resistance reversal agents. National AACR meeting, April-
2011, Orlando, FL.
Jay Patel, Vijaya L. Korlipara; Design, synthesis and evaluation of OSI-930 analogues as dual inhibitors of c-kit and KDR tyrosine kinase. National ACS meeting, Aug-2009, Washington DC.
Jay Patel, An-Hu Li, Hanquing Dong, Mark J. Mulvihill, Vijaya L. Korlipara;
Polymethylhydrosiloxane (PMHS)/Trifluoroacetic acid (TFA):A novel system for reductive
amination reactions., National ACS meeting, August-2006, Boston, MA.
Professional affiliations and activities
Member, American Chemical Society (ACS)
Member, American Association of Cancer Research (AACR)
Member, American Association of Pharmaceutical Society (AAPS)
Member, Society of Toxicology
References
Dr. Vijaya L. Korlipara
Professor of Pharmaceutical Sciences and Director, Institute for Biotechnology
Pharmaceutical Sciences
St.Albert’s Hall, Room 301
Queens, NY 11439
aca1y4@r.postjobfree.com
Dr. Tanaji T. Talele
Associate Professor
Pharmaceutical Sciences
St.Albert’s Hall, Room G010B
Queens, NY 11439
aca1y4@r.postjobfree.com
Dr. Zhe-Sheng Chen
Professor
Pharmaceutical Sciences
St.Albert’s Hall, Room SB24C
Queens, NY 11439
aca1y4@r.postjobfree.com