Andrew S. Rosenthal, Ph.D.

**** ******** ** *******, ** 20855 abqsjc@r.postjobfree.com 215-***-****

OBJECTIVE

Seeking a challenging position that will utilize my knowledge and expertise in synthetic organic

chemistry and my proficiency in writing and presenting my work while promoting the goals of the

company

ACCOMPLISHMENTS

Developed potent and highly selective compounds for Ubiquitin specific protease 1 (USP1) inhibition

Synthesized the most selective and potent inhibitor of BLM helicase reported to date

Successfully optimized potent inhibitors of kinases DYRK1A, DYRK1B and CLK4

Presented my research at both the regional and national levels

Designed and synthesized several unique potent antimalarial and anticancer drug candidates

Co authored eight manuscripts (one of which as first author) and three patents

Mentored two summer students in organic synthesis, medicinal chemistry and lab technique

SKILLS

Skilled at working in a multidisciplinary team environment

Experienced at writing peer reviewed scientific manuscripts

Effective at communicating project goals and progress both to colleagues and at professional

meetings

Proficient in advanced organic synthesis and purification techniques

Characterization of organic molecules (1H, 13C, 19F NMR; optical rotation; FT/IR; LC/MS; GC/MS;

UV/Vis; Meltemp; MS (ESI); Preparative and analytical TLC)

EXPERIENCE

National Center for Advancing Translational Sciences (NCATS), formerly NIH Chemical Genomics Center

(NCGC), National Institutes of Health (NIH), Rockville, MD

IRTA Postdoctoral Fellow (advisor: David Maloney, PhD), 2009 present

o Developed potent inhibitors of kinases DYRK1A, DYRK1B (first reported), and CLK4, protease

USP1, and BLM helicase

o Prepared internal scientific reports to secure funding

Rohm & Haas, Springhouse Technical Center, Advanced Biosciences, Springhouse, PA

Summer Intern (advisor: Marlin Kinzey, PhD), 2004

o Worked on ion exchange resin synthesis and column analysis. Prepared ready to sell analytical

columns.

Merck Research Laboratories, Medicinal Chemistry, West Point, PA

Summer Intern (advisor: Cory R. Theberge, PhD), 2003

o Synthesized and purified unique asymmetric organic compounds for a the CGRP receptor

EDUCATION

Johns Hopkins University, Baltimore, MD, 2004 2009

Ph.D. Degree in Organic Chemistry (advisor: Prof. Gary H. Posner), June 2009

o Thesis: Design and Synthesis of Novel Antimalarial and Anticancer Artemisinin Derived Trioxanes

and Thiol Olefin Co Oxygenation (TOCO) Derived Endoperoxides

o Designed and synthesized semi synthetic trioxanes (based on artemisinin) with anti malarial and

anticancer drug activity

o Synthesized totally synthetic trioxanes with antimalarial activity using photochemistry developed

in the Posner lab

o Worked as the liaison between the organic chemists and the biologists running the anti malarial

in vitro assay. Prepared samples and processed data.

o Developed and maintained a lab database of over 1000 synthesized compounds

o Improved and maintained a lab inventory of over 5000 chemicals

M.S. Degree in Organic Chemistry (advisor: Prof. Gary H. Posner), May 2007

Teaching assistant (instructor: Dr. David Klein), 2004 2009

Sarah and Adolph Roseman Achievement Award, 2008 (Recognition of outstanding research

accomplishment in chemistry during the last year of study)

Dickinson College, Carlisle, PA, 2000 2004

Bachelor of Science in Chemistry, Magna Cum Laude, May 2004

o Undergraduate research: Nucleophilic Substitution of ( 6 arene) Chromium Complexes in an

Ionic Liquid Solvent

o Recipient of the Richard M. Sheeley Scholarship (Chemistry), 2004

University of East Anglia, Norwich, UK, Fall 2002 (semester abroad program)

University of East Anglia, School of Chemistry, Norwich, UK

COMMUNITY OUTREACH

Bread Baking and Hands On Science Adventure, Rockville, MD, 2012

Hosted by Johns Hopkins University

Led ~800 elementary school students in preparation of slime

Frontiers in Science and Medicine Day, Rockville, MD, 2011 2012

Sponsored by the Universities at Shady Grove

Led ~600 elementary school students in demonstrations on chemical reactions

Journeys in Engineering, Technology and Science, Rockville, MD, 2011

Sponsored by the Universities at Shady Grove

Led discussion and demonstration for ~50 middle school students and parents

PUBLICATIONS

1. Nguyen, G.H.; Dexheimer, T.S.; Rosenthal, A.S.; Chu, W.K.; Mosedale, G.; Bachrati, C.Z.; Schultz, L.;

Sakurai, M.; Savisky, P.; Abu, M.; Bohr, V.A.; Harris, C.C.; Jadhav, A.; Gileadi, O.; Maloney, D.J.;

Simeonov, A.; Hickson, I.D. A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome

Stability in Human Cells. Manuscript submitted.

2. Rosenthal, A.S.; Dexheimer, T.S.; Jadhav, A.; Simeonov, A.; Maloney, D.J. Structure Activity

Relationships of a Novel Inhibitor of Blm Helicase Manuscript in preparation.

3. He, R.; Mott, B.T.; Rosenthal, A.S.; Genna, D.T.; Posner, G.H.; Arav Boger, R. An Artemisinin Derived

Dimer has Highly Potent Anti Cytomegalovirus (CMV) and Anti Cancer Activities. PLoS One, 2011, 6, 8,

e24334.

4. Rosenthal, A.S.; Tanega, C.; Shen, M.; Mott, B.T.; Bougie, J.M.; Nguyen, D T.; Misteli, T.; Auld D.S.;

Maloney, D.J.; Thomas, C.J. Potent and selective small molecule inhibitors of specific isoforms of Cdc2

like kinases (Clk) and dual specificity tyrosine phosphorylation regulated kinases (Dyrk). Bioorg. Med.

Chem. Lett. 2011, 21, 3152 3158.

5. Arav Boger, R.; He, R.; Chiou, C.J.; Liu, J.Y.; Woodard, L.E.; Rosenthal, A.S.; Brando Jones, L.; Forman,

M.; Posner, G.H. Artemisinin Derived Dimers have Improved Anti Cytomegalovirus Activity Compared

to Artemisinin Monomers. PLoS One, 2010, 5, 4, e10370.

6. Rosenthal, A.S.; Chen, X.; Liu, J.; Singh, N.; Lai, H.; Sasaki, T.; Shapiro, T.A. and Posner, G.H. Malaria

Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Which Are Also

Selectively and Powerfully Cytotoxic to Cancer Cells. J. Med. Chem. 2009, 52, 1198 1203.

7. Hartwig, C.L.; Rosenthal, A.S.; D Angelo, J.G.; Griffin, C.E.; Posner, G.H. and Cooper, R.A. Accumulation

of Artemisinin Trioxane Derivatives Within Neutral Lipids of Plasmodium falciparum Malaria Parasites is

Endoperoxide Dependent. Biochem. Pharm. 2009, 77, 322 326.

8. Posner, G.H.; Rosenthal, A.S.; Kalinda, A.S. Chang, W.; Hess, L.; Woodard, L.; Sinishtaj, S.; Usera, A. R.;

Maio, W.; D Angelo, J. G.; Petersen, K. S.; Stohler, R.; Borstnik, K.; Paik, I. H.; Chollet, J.; Santo Tomas,

J.; Snyder, C.; Rottmann, M.; Wittlin, S.; Brun, R.; Shapiro, T. A. Malaria Infected Mice Are Cured by

Oral Administration of New Artemisinin Derivatives. J. Med. Chem. 2008, 51, 1035 1042.

9. Posner, G.H.; Paik, I H.; Chang, W.; Borstnik, K.; Sinishtaj, S.; Rosenthal, A.S. and Shapiro, T.A. Malaria

Infected Mice Are Cured by a Single Dose of Novel Artemisinin Derivatives. J. Med. Chem. 2007, 50,

2516 2519.

10. Kim, J.; Li, H.B.; Rosenthal, A.S., Sang, D.; Shapiro, T.A.; Bachi, M.D. and Posner, G.H. Ground State

Oxygen in Synthesis of Cyclic Peroxides. Part 1: Benzo Fused Ketals. Tetrahedron. 2006, 62, 4120

4127.

PATENTS

1. Thomas, C.J; Mott, B.T.; Tanega, C.; Shen, M.; Auld, D.; Rosenthal, A.S.; and Maloney, D.J. Preparation

of Quinazolin 4 amine Derivatives as Potent and Selective Inhibitors of Clk or Dyrk1A Kinase Intl.

Patent WO/2011/041655, published April 7, 2011.

2. Posner, G.H. and Rosenthal, A.S. Trioxane Dimer Sulfur Compounds. Intl. Patent WO/2010/009428,

published January 21, 2010.

3. Posner, G.H.; Paik, I H.; Borstnik, K.; Chang, W.; Sinishtaj, S.; Maio, W.A.; D'Angelo, J.G.; Woodard, L.E.;

Kalinda, A.S.; Usera, A.R.; Hess, L.C.; Rosenthal, A.S.; Oh, S. and Baege, A.C. Trioxane dimers

(artemisinin derivatives) having anticancer and antimalarial activities, processes for preparing them,

and pharmaceutical compositions containing them. Intl. Patent WO/2007/067333, published June 14,

2007.

PRESENTATIONS

1. Rosenthal, A.S.; Posner, G.H. Advances in the Anticancer Properties of Semisynthetic Artemisinin

Dimers Abstracts of the 42nd Middle Atlantic Regional Meeting of the American Chemical Society,

College Park, MD, United States, May 21 24 (2011), MARM 241.

2. Rosenthal, A.S.; Tanega, C.; Shen, M.; Mott, B.T.; Austin, C.P.; Auld, D.; Maloney, D.J. and Thomas, C.J.

Potent and selective small molecule in vitro inhibitors of cdc2 like (Clk) and dual specificity tyrosine

phosporylation regulated (Dyrk) kinases. Abstracts of Papers, 241st ACS National Meeting, Anaheim,

CA, United States, March 27 31 (2011), MEDI 326.

3. Rosenthal, Andrew S.; Tanega, Cordelle; Shen, Min; Mott, Bryan T.; Auld, Douglas S.; Inglese, James;

Austin, Christopher P.; Maloney, David J.; Thomas, Craig J. Design and synthesis of substituted 6

arylquinazolin 4 amines as potent and selective inhibitors of members of the CLK and DYRK kinase

families. Abstracts of Papers, 240th ACS National Meeting, Boston, MA, United States, August 22 26

(2010), MEDI 174.

4. Rosenthal, Andrew S.; Chang, Wonsuk; Sinishtaj, Sandra; Borstnik, Kristina; Paik, Ik Hyeon; Shapiro,

Theresa A.; Posner, Gary H. Rational Design of Artemisinin Derived Trioxane Dimers that Cure Malaria

Infected Mice. Abstracts of the 39th Middle Atlantic Regional Meeting of the American Chemical

Society, Collegeville, PA, United States, May 16 18 (2007), MARM 141.

5. Posner, G.H.; Chang, W.; Rosenthal, A.S.; Paik, I H.; Borstnik, K.; Sinishtaj, S.; Usera, A.; Hess, L.;

Woodard, L.; Petersen, K.S. and Shapiro, T.A. Malaria Infected Mice are Cured by New Trioxane Dimers.

Abstracts of the 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene,

Philadelphia, PA, United States, November 4 8 (2007), ASTMH 653.

6. Rosenthal, A.S. An Introduction to Medicinal Chemistry: Current Developments in Malaria Research.

Washington and Jefferson College, Washington, PA, United States, October 4, 2007.

REFERENCES

Prof. Gary H. Posner (abqsjc@r.postjobfree.com) Dr. David J. Maloney

Johns Hopkins University (abqsjc@r.postjobfree.com)

3400 N. Charles St. National Center for Advancing

Dept of Chemistry Translational Sciences/NIH

Baltimore, MD 21218 9800 Medical Center Drive

410-***-**** Building B, Room 3005

MSC:3370

Dr. Craig J. Thomas Bethesda, MD 20892 3370

301-***-****

(abqsjc@r.postjobfree.com)

National Center for Advancing

Prof. Michael S. Holden

Translational Sciences/NIH

9800 Medical Center Drive (abqsjc@r.postjobfree.com)

Building B, Room 3005 Dickinson College

MSC:3370 Department of Chemistry

Bethesda, MD 20892 3370 PO Box 1773, Carlisle, PA 17013

301-***-**** 717-***-****

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