Gary Michael Lee *** Hiller Street

Belmont, CA **002

abohln@r.postjobfree.com

650-***-****

SENIOR RESEARCH SCIENTIST

Process Research and Development - Organic Synthesis - Asymmetric Molecules

- Method Development - Regulated Environments

Senior Scientist in the Pharmaceutical Industry with an emphasis on Process

Research and Development. Experienced Researcher with "hands-on"

experience in bench to pilot plant development as well as chemical

production. My passions include conceptual design, process optimization,

and production of the first kilogram of API.

Selected Accomplishments

. Developed stereoselective routes to CNS target SCH 39166 that resulted

in a more efficient/high throughput process.

. Developed an enantioselective reaction through a novel "chiral

aziridinum" intermediate.

. Prepared Toxicology/Phase I batches of the pro-drug of NOXAFIL.

. Established an alternative route to RO5006819 that led to a 40% more

efficient process.

. Developed an efficient method to construct the triazolone headpiece in

an NNRTI program.

. Key contributor to the downstream process of CodeXolTM.

Professional Experience

CODEXIS INC, Redwood City, CA

Scientist July 2011-October 2012

. Developed and explored recovery/upgrading processes for CodeXolTM, a

bio-based process for the manufacture of detergent alcohols from

lignocellulosic biomass.

. Composed DSP Technical Transfer document for a pilot facility(1500 L)

in Rivalta (Italy).

. Performed DSP on 650 L scale for production samples.

. Execute fermentations (e.coli.) on 30 L scale.

ROCHE PALO ALTO LLC, Palo Alto, CA

Research Scientist II 2001-March 2010

. Prepared/developed catalytic homogenous/heterogeneous catalysts for

catalytic hydrogenation and reductive amination processes.

. Produced APIs and intermediates thereof to be utilized in

Pharmaceutical Development.

. Created process designs for NCE and evaluated their process potential.

. Developed chemical transformations to be run safely/efficiently and

reproducibly in fixed reactors.

. Composed Pilot Plant Procedures and complete Batch Records to meet

cGMP requirements.

. Performed large-scale reactions under cGMP in fixed reactors in Kilo

Lab and Pilot Plant.

. Demonstrated use of automation equipment and performed structural

identification by spectrophotometric analysis.

SCHERING PLOUGH RESEARCH INSTITUTE, Kenilworth, NJ

Senior Scientist 1995-2001

Associate Principal Scientist 1991-1995

. Designed and developed safe and economical processes to experimental

Active Pharmaceutical Ingredients (APIs).

. Produced APIs and intermediates thereof to be utilized in

Pharmaceutical Development.

. Wrote Pilot Plant Procedures and complete Batch Records to meet cGMP

requirements.

. Acted as an "in-house" consultant for issues related to process

chemistry and engineering, QA/QC, safety, stability and formulation.

. Supervised a junior level chemist.

. Supervised summer interns.

. Used automated reaction technology.

. Studied Statistical Design.

. Worked cross-functionally within organization to achieve common goals.

Previous Experience.

SYVA COMPANY, Cupertino, CA

Chemist 1

. Responsibilities included the preparation of drug derivatives and drug-

enzyme conjugations as components in medical diagnostic assays.

Education

Postdoctorate

Yale University, New Haven, CT

Advisor: Harry H. Wasserman

Research Focus: The Chemistry of Vicinal Tricarbonyls.

Ph.D. in Chemistry

The Pennsylvania State University, University Park, PA

Advisor: Steven M. Weinreb

Thesis title: Investigations into the Transition Metal Catalyzed

Cyclization of Unsaturated ?-Mono Chloro Esters, Acids and Olefinic

Polychloromethyl Derivatives.

B.S. in Chemistry

The University of California, Berkeley, CA

Publications and Patents

James P. Davidson, Keshab Sarma, Dan Fishlock, Michael H. Welch, Sunil

Sukhtankar, Gary M. Lee, Michael Martin, Gary F. Cooper, "A Synthesis of

3,5-Disubstituted Phenols" OPRD 2010, 14, 477.

Dinesh Gala, Andrew J. Goodman, Gary Lee, Hongbiao Liao, Martin L.

Schwartz, Suhan Tang, David J. S. Tsai, Wenxue Wu, "Preparation Of

Pharmaceutical Salts", US 7,534,884 B2, 2009.

Humberto Bartolome Arzeno, Gary M. Lee, Michael Martin, Keshab Sarma, Jiang

Zhu, "Process For Preparing Triazolones", WO 2008/145563 A2, 2008/US

2009/0012304 A1, 2009.

Dinesh Gala, Andrew J. Goodman, Gary Lee, Hongbiao Liao, Martin L.

Schwartz, Suhan Tang, David J. S. Tsai, Wenxue Wu, "Preparation Of Salts Of

4-[4-[(1R)-4[-(Trifluoromethyl)phenyl]-2-Methoxyethyl]-(3S)-Methyl-1-

piperazinyl]-4-Methyl-1-[(4,6-Dimethyl-5-pyrimidinyl)carbonyl]", US

6,943,251 B2, 2005.

William Leong, Minzhang Chen, Bosco A. D'sa, Man Zhu, Tong Xiao, Xiongwei

Shi, Suhan Tang, Dinesh Gala, Andrew J. Goodman, Christopher M. Nielsen,

Gary M. Lee, Juan A. Gamboa, Andrew D. Jones, "Synthesis Of Piperidine and

Piperazine Compounds As CCR5 Antagonists", WO 03/084950 A1, 2003/US

6,992,189 B2, 2006.

Wenxue Wu, Hongbiao Liao, David J. S. Tsai, David R. Andrews, Dinesh Gala,

Gary M. Lee, Martin Lawerence Schwartz, Timothy L. McAllister, Xiaoyong Fu,

Donal Maloney, Tiruvettipuram K. Thiruvengadam, Chou-Hang Tann, "Stereo

selective Akylation Of Chiral 2-Methyl-4-Protected Piperazines", WO

03/084942 A2, 2003/US 6,872,826 B2, 2005.

Dinesh Gala, Andrew J. Goodman, Gary Lee, Hongbiao Liao, Martin L.

Schwartz, Suhan Tang, David J. S. Tsai, Wenxue Wu, "Process For The

Preparation Of Compositions Having An Increased Amount Of Pharmaceutically

Active Salts Of Rotamers", WO 03/048153, 2003.

G. M. Lee, J. Eckert, D. Gala, M. Schwartz, P. Renton, E. Pergament,

M. Whittington, D. Schumacher, L. Heimark, P. Shipkova, "Synthesis of

Injectable Antifungal SCH 59884", OPRD 2001, 5, 622.

Robert Aslanian, Gary M. Lee, Radha Iyer, N.-Y, Shih, John J.

Piwinski, Richard W. Draper and Andrew T. McPhail "An Asymmetric

Synthesis of the Novel H3 Agonist -(3R, 4R)-3-(4-imidazolyl)-4-

methylpyrrolidine

Dihydrochloride (SCH 50971)", Tetrahedron Asymmetry 2000, 11, 3867.

Richard W. Draper, Donald Hou, Radha Iyer, Gary M. Lee, Jimmy T.

Liang, Janet L. Mas, Wanda Tormos, Eugene Vater, Frank Gunter,

Ingrid Mergelsberg and Dominik Scherer, "Novel Stereo selective Synthesis

of

the Fused Benzazepine Dopamine D1 Antagonist(6aS,13bR)-11-Chloro-

6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphtha[2,1-b]azepin-12-ol

(SCH 39166): 1. Aziridinium Salt Based Syntheses", OPRD 1988, 2, 175.

Richard W. Draper, Donald Hou, Radha Iyer, Gary M. Lee, Jimmy T.

Liang, Janet L. Mas, Eugene Vater "Novel Stereoselective Synthesis

of the Fused Benzazepine Dopamine D1 Antagonist

(6aS,13bR)-11-Chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-

benzo[d]naphth[2,1-b]azepin-12-ol (Sch 39166): 2. L-Homophenylalanine-

Based

Syntheses", OPRD 1998, 2, 186.

Donald Hou, Richard W. Draper, Gary M. Lee and Jan L. Mas, "Process For

Preparing Benzazepine Intermediates For The Synthesis of D1 Antagonists",

U.S. Patent 5,670,666,1997.

Donald Hou, Richard W. Draper, Gary M. Lee, Janet L. Mas, "Process For

Preparing Benzazepine Intermediates For The Synthesis Of D1 Antagonists",

U.S. Patent 5,461,147,1995.

Harry H. Wasserman and Gary M. Lee, "The Chemistry of Vicinal

Tricarbonyls", Tetrahedron Lett. 1994, 35, 9783.

Gary M. Lee and Steven M. Weinreb, "Transition Metal Catalyzed

Intramolecular Cyclizations of (Trichloromethyl)alkenes", J. Org. Chem.

1990, 55, 1281.

James C. Phelps, David E. Bergbreiter, Gary M. Lee, Rosanna Villani

and Steven M. Weinreb, "A Polyethylene-Bound Ruthenium (II) Catalyst for

Inter- and Intramolecular Kharasch Reactions", Tetrahedron Lett. 1989, 30,

3915.

Gary M. Lee, M. Parvez and Steven M. Weinreb, "Intramolecular Metal

Catalyzed Kharasch Cyclizations of Olefinic ?-Halo Esters And Acids",

Tetrahedron 1988, 44, 4671.

Contact this candidate