Medical Development
Resume:
Yuanming Zhang, MD, MS
ADDRESS: Barnes-
Jewish Hospital
Washington University in St. Louis
Department of Pathology and Immunology
St. Louis, MO 63110
Tel: Work: 314-***-****
Mobile: 484-***-****
Fax: 314-***-****
E-mail: abkqem@r.postjobfree.com
ABP BOARD STATUS Certified in AP/CP on
8/2/2012
EDUCATION:
Fellowship
Hematopathology Fellow
July 1st 2012-June 30th 2013 Barnes-Jewish
Hospital
(Ranked #6 hospital in US in 2012)
(The nation's 2nd largest bone marrow transplant center)
(High case volume with complex in-house and consult cases)
Washington University in St. Louis
Department of Pathology and Immunology
St. Louis, Missouri
Anticipated completion: June 2013
Residency
July 2008-June 2012 State University
of New York at Stony Brook Medical Center
Pathology Residency Program
Anatomic Pathology and Clinical Pathology track
Stony Brook, New York
Performance during residency 2012 Resident in-service
exam summary for PGY-4
Overall percentile nationwide: 99
Cytopathology percentile nationwide: 99
Surgical pathology percentile nationwide: 95
Hematopathology percentile nationwide: 95
Chief resident: Jan.2011-June 2011
Medical School
Sept. 1990-July 1995 Beijing Medical
University
(NKA: Peking University Health Science Center)
Beijing, China
Bachelor of Medicine
Graduate school
Sept.1999-Dec.2001 University of
Pennsylvania
Cell and Molecular Biology Group
Microbiology and Virology Program
Philadelphia, PA
Masters of Science
July 1995-June 1998 Institute of
Epidemiology and Microbiology
Beijing, China
Masters
of Pathogenic Biology (Bacteriology)
AWARDS/HONORS:
1990-1991 First
class scholarship for Excellent Student of Beijing Medical
University
1991-1992 First
class scholarship for Excellent Student of Beijing Medical
University
1992-1993 Guanghua
Scholarship (The highest scholarship in
Beijing Medical University) for Excellent Student of Beijing Medical
University
1993-1994 Guanghua
Scholarship (The highest scholarship in
Beijing Medical University) for Excellent Student of Beijing Medical
University
June 1995 Gold
medal for "Excellent Graduate" of Beijing Medical University
(Top 5% of all graduates of BMU received this honor in 1995).
ECFMG CERTIFICATION: Certified on 3/30/2007
RESEARCH AND PUBLICATIONS:
Yuanming Zhang, Ihsane Ouansafi, Wayne Tam, John P. Leonard,
Attilio Orazi. Diffuse variant
of lymphocyte predominant Hodgkin lymphoma: a diagnostic challenge.
Journal of Hematopathology (15 August 2012), pp. 1-6
Tove' C. Bolken, Sylvie Laquerre, Yuanming Zhang, Thomas R. Bailey,
Daniel C. Pevear,
Shirley S. Kickner, Lindsey E. Sperzel, Kevin F. Jones, Travis K.
Warren, S. Amanda Lund, Dana L.
Kirkwood-Watts, David S. King, Amy C. Shurtleff, Mary C. Guttieri,
Yijun Deng, Maureen Bleam and
Dennis E. Hruby, Identification andcharacterization of potent
small molecule inhibitor of hemorrhagic
fever New World arenaviruses. Antiviral research. 2006 Feb 69(2): 86-
97.
3. Yuanming Zhang, and Jeffrey M. Bergelson.
Adenovirus receptors. Journal of Virology. 2005. 79: 121**-*****
4. Yuanming Zhang, John C. Rassa, Maria Elena deObaldia, Lorraine
M. Albritton, and Susan R. Ross.
Identification of the Receptor Binding Domain of the Mouse Mammary
Tumor Virus Envelope Protein.
Journal of Virology. 2003 77: 104**-*****.
5. S. Hein, V. Prassolov, Yuanming Zhang, Ivanov D, Lohler J, S.
Ross, and C. Stocking.
Sodium-Dependent Myoinositol Transporter 1 Is A Cellular Receptor
For Mus Cervicolor M813
murine leukemia virus .Journal of Virology, 2003 May;77(10):5926-
32.2.
6. John Rassa, Jennifer Meyers, Yuanming Zhang, Rama Kudaravalli,
Susan R. Ross. 2002.
Murine retroviruses activate B cells via Toll-like receptor 4.
Proceedings of the National Academy of Sciences(PNAS), 99(4): 2281-
2286.
7. Carolyn A. Cuff, Devashish Kothapalli, Ijeoma Azonobi, Sam Chun,
Yuanming Zhang,
Richard Belkin, Christine Yeh, Anthony Secreto, Richard K. Assoian,
Daniel J. Rader, and Ellen Pur .
2001.The adhesion receptor CD44 promotes atherosclerosis by
mediating inflammatory cell recruitment
and vascular cell activation. The Journal of Clinical Investigation,
108 (7): 1031-1040.
POSTERS AND ABSTRACTS:
Yuanming Zhang, Sonya Hwang, Michael Pearl, Carmen Tornos. Clusters
of non-neoplastic
epithelial signet ring cells in cervical curettages, a source of
diagnostic error: Report of 6 cases.
CAP 2012, September 9-12, 2012, Manchester Grand Hyatt, San Diego,
California
2. Yuanming Zhang, Peihong Hsu, Ann-Leslie Zaslav, Marc Golightly,
Fengshuo Lan, Youjun Hu.
Immunophenotypical and Cytogenetic Alterations of Adult Precursor B-
cell Lymphoblastic Leukemia at
Relapse with Unusual Presentation. CAP 2011, Sept.11-14, Grapevine
(Dallas/Ft. Worth), Texas.
3. Yuanming Zhang, Roberto Bergamaschi, Philip Kane and Meenakshi
Singh.
Granulomatous inflammation presenting as ileocecal mass with bladder
and abdominal wall involvement.
CAP'09 The pathologists' meeting. Washington DC. October 11-14,
2009.
4. Yuanming Zhang, Cheryl Kinney, Yun Seung Kyung, Shantha Raju,
Mike Naso, Margie Ciancio,
Pam Hawley-Nelson, Mark Anderson, Bernie Scallon, Subinay Ganguly,
Gordon Moore, Cam Ngo,
and Haimanti Dorai. Development of Low Fucose Host Expression
Systems to Generate Antibodies with
Enhanced Antibody-Dependent Cellular Cytotoxicity Activity.
Centocor R&D Inc. (Johnson and Johnson) Poster Day. Radnor, PA,
July 19, 2006.
Yun Seung Kyung, Yuanming Zhang, Justin Weaver, Hillary Millar,
Claudia Tulanoswski,
Cam Ngo and Haimanti Dorai. Development of Low Fucose Host
Expression Platform to Generate
Antibodies with Enhanced Antibody-Dependent Cellular Cytotoxicity
Activity.
Centocor R&D Inc. (Johnson and Johnson) Poster Day. Radnor, PA,
July 19, 2006.
Yuanming Zhang, Susan Pichla, Mark Drinker and Jeffrey Bergelson.
Development of Ad5-based
vaccination vectors. Children's Hospital of Philadelphia Poster Day.
2005.
Yuanming Zhang, Amy C. Shurtleff Mary C. Guttieri, Maureen R.
Kealey, Gillian R. Kunze,
Thomas R. Bailey, Jodie C. Hamrick, Theodore J. Nitz, Yijun Deng,
Daniel C. Pevear and Sylvie Laquerre.
Identification and characterization of potent and specific small
molecule inhibitors of hemorrhagic fever
New World Arenaviruses.
American Society of Microbiology Biodefense Meeting. Baltimore, MD,
March 2004.
Andrea Cuconati, Yuanming Zhang, Amy Shurtleff, Gael LeHenaff,
Gillian Kunze,
Maureen Kealey, Thomas Bailey, Dan Pevear, and Sylvie Laquerre.
Discovery of Antiviral Drugs
Against Old-World Arenaviruses.
American Society of Microbiology Biodefense Meeting. Baltimore, MD,
March 2004.
Sylvie Laquerre, Srikrishna Chetty, Yuanming Zhang, Robert Direnzo,
David Rys, C line Simon,
Gillian Kunze, Tina Tull, Christopher Burns, Philip Wyde, Daniel
Pevear and Theodore J. Nitz.
In Vitro and In Vivo Studies of An Efficacious Small Molecule Fusion
Protein Inhibitor of RSV.
American Society of Virology Meeting. Baltimore, MD, July 2003.
Rassa, J. C., Meyers, J. L., Yuanming Zhang, Kudaravlli, R., and
Ross, S.R. Mouse Mammary
Tumor Virus Activation of B Lymphocytes is Mediated by Toll-like
Receptors.
Keystone Meeting on Innate Immunity. Taos, NM. February 2002.
11. Rassa, J. C., Meyers, J. L., Yuanming Zhang, Kudaravalli, R.,
and Ross, S.R. MMTV Activation of B
Lymphocytes is Mediated by Toll-Like Receptors.
Retrovirus Meeting. Cold Spring Harbor, NY. May 2001.
12. Rassa, J. C., Meyers, J. L., Yuanming Zhang, Kudaravalli, R.,
and Ross, S.R. MMTV Activation of B
Lymphocytes is Mediated by the LPS Receptor Toll-Like Receptor 4
(TLR-4).
12th International Workshop on Retroviral Pathogenesis. Annapolis,
MD. October 2000.
PATENTS:
One of the Main Inventors of the International Patent:
Modified Treponema Pallidum Outer membrane Protein, its Immunoassay
Use and Immunoassay Kit.
One of the Main Inventors of the U.S. Patent:
Sulfonyl Semicarbazides, Semicarbazides and Ureas, Pharmaceutical
Compositions Thereof, and
Methods for Treating Hemorrhagic Fever Viruses, Including Infections
Associated with Arena Viruses.
INTRADEPARTMENTAL PRESENTATIONS:
Hematopathology
Nov. 2009 Hematopathology tumor board
Feb. 2010-Mar.2010 Resident review sessions on lymphoma and
leukemia cases
3/17/2010 Clinical conference: Epstein-Barr virus-related
lymphoid malignancies.
2/16/2010 Journal club: Starczynowski DT, et al.
Identification of miR145 and miR146a as
mediators of the 5q- syndrome
phenotype. Nature Medicine, Sep.2009, 16:49-58
12/29/2010 Clinical conference: Diffuse variant of
lymphocyte predominant Hodgkin lymphoma:
a diagnostic challenge.
1/18/2011 Journal club: Immunohistochemical
detection of ZAP70 in chronic lymphocytic leukemia
predicts immunoglobulin heavy
chain gene mutation status and time to progression.
Modern Pathology (2010) 23, 1518-1523.
8/3/2012 Journal club: Essential thrombocythemia versus
early primary myelofibrosis: a multicenter
study to validate theWHO
classification. Blood, 2011 117: 5710-5718
7/2012-present Present weekly for lymphoma, leukemia and bone
marrow transplant conference
Non-hematopathology
Sept. 2008 Unknown slide conference, Metastatic Merkel
cell carcinoma.
7/20/2009 Journal club: Isabelle Mercier, et al. Genetic
Ablation of Caveolin-1 Drives
Estrogen-Hypersensitivity and the
Development of DCIS-Like Mammary Lesions.
American Journal of Pathology.
2009;174:1172-1190.
7/15/2009 Clinical conference: Renal Medullary
Carcinoma: Is There Any Hope?
Jan. 2010-June 2010 Colorectal tumor board
2012. Soft tissue tumor board
11/30/2011 Clinical conference: Selective Review of Bone
Tumors.
2/21/2012 Journal club: TP53 mutations in serous tubal
intraepithelial carcinoma and concurrent pelvic
high-grade serous carcinoma-evidence
supporting the clonal relationship of the two lesions.
J Pathol 2012; 226: 421-426, Feb.2012
TEACHING EXPERIENCE:
Medical student teaching
2008, gross anatomy
2009, gastrointestinal pathology, liver
cirrhosis
2010, endocrine pathology, adrenal
PROFESSIONAL ASSOCIATIONS
College of American Pathologists.
Membership since 2008.
United States and Canadian Academy
of Pathology. Membership since January, 2010.
American Society of Clinical
Pathology, Membership since May, 2010.
COMMITTEE MEMBERSHIP:
Surgical review committee of SUNY at
Stony Brook Medical Center (since 01/2010)
ASCP resident representative of SUNY at Stony
Brook Medical Center (since 05/2010)
EMPLOYMENT HISTORY:
Centocor R&D Inc., a Johnson and Johnson company
June 2005-June 2008
Senior Associate Scientist. Cell
Biology, Pharmaceutical Development
Development high-yield CHO cell
line for production of therapeutic monoclonal antibodies.
Development of Low Fucose Host
Expression Systems to Generate Antibodies with
Enhanced Antibody-Dependent
Cellular Cytotoxicity Activity Against Tumor Cells.
Drexel University College of Medicine
Aril 2005-June 2005
Research Associate, Development of
anti-West Nile Virus compound inhibitors.
Children's Hospital of Philadelphia
April 2004- April 2005
Research Fellow, Dept. of
Immunology and Infectious Diseases
Adenovirus 5-based gene therapy
vector for HIV vaccine and other Vaccines.
ViroPharma Incorporated, Exton, PA
Nov. 2002- Mar. 2004
Scientist, Discovery Department
Supervisory activity: Supervised
3 full-time co-op students.
Bioassay development for bio-
defense projects and SARS-CoV HTS.
MOA study of anti-Respiratory
Syncytial Virus (RSV) drug candidate.
University of Pennsylvania, Philadelphia, PA
Jan. 2002-Oct. 2002
Research Specialist, Dept. of
Microbiology and Cancer Center.
MMTV and human breast cancer.
Golden Bridge International Biotech Co., Ltd, Beijing, P.R.China
July 1998-July 1999
Scientist, R&D Department.
Developed ELISA diagnostic kit for Syphilis.
SKILL SET:
Anatomic pathology: Frozen sections, specimen grossing, case
workup and sign-out
Hematopathology: Specimen grossing, case workup and sign-out
Clinical pathology: Working knowledge of clinical pathology
Molecular Biology: Purification of DNA and RNA, PCR, RT-PCR,
SOE-PCR and site-directed mutagenesis.
Gene cloning and protein
expression in E.coli, mammalian and insect cells.
Protein purification,
characterization and enzymatic activity determination
SDS-PAGE, Northern, Western and
Southern blotting.
Yeast two-hybrid screening
Virology: Virus growth, virus isolation, plaque
assay.
Generation, purification and
characterization of drug resistant virus isolates.
Purification, construction of
recombinant viruses,
Baculovirus expression system.
Immunology: Development of stable cell lines
expressing therapeutic monoclonal antibodies.
Flow Cytometry,
immunofluorescence, immunoprecipitation.
Hybridoma handling, monoclonal
antibody purification.
Tissue culturing: Cell culture, transient and stable cell
transfection.
Animal handling: Drug injection of mice, tissue and cell
isolation, sectioning of different
organs, histochemical staining,
drug metabolism studies with frog and rabbit.
High throughput screening assay development:
Whole cell-based and
biochemical assays.
Mechanism of Action (MOA) studies of anti-viral drugs
Respiratory Syncytial Virus
(RSV) and New World Arena viruses.
BiomekFx Robot System: Operation for high-throughput screening for
drug candidates.
References available upon request
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