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Research Interests

. Nuclear Medicine

. Regularized image reconstruction for nuclear medicine

. Imaging system optimization and evaluation

. Imaging physics

. Image statistics

. Myocardial perfusion SPECT (MPS)

. Multi-modality imaging

. Computer aided detection (CAD)

. Breast cancer risk prediction and diagnosis

Education

12/2005 Ph.D. in Biomedical Engineering

Dissertation: "Three-class ROC Analysis"

University of North Carolina, Chapel Hill, NC

06/2000 B.S. in Nuclear Engineering

Tsinghua University, Beijing, China

Experience

09/2009-11/20 Instructor, Johns Hopkins Medical Institutions, Baltimore, MD

10

01/2008-09/20 Research Associate, Johns Hopkins Medical Institutions,

09 Baltimore, MD

01/2006-12/20 Postdoctoral research fellow, Johns Hopkins Medical

07 Institutions, Baltimore, MD

05/2005-07/20 Intern, General Electric Global Research Center, Niskayuna, NY

05

07/2002-12/20 Trainee, Johns Hopkins Medical Institutions, Baltimore, MD

05

08/2000-06/20 Research Assistant, University of North Carolina, Chapel Hill,

02 NC

Awards

1. IEEE Nuclear and Plasma Sciences Society, Bruce H. Hasegawa Young

Investigator Medical Imaging Science Award, 2010

"This award is given annually (previously only in in odd-numbered

years) to a young individual in recognition of significant and

innovative technical contributions to the field of medical imaging

science." -- http://ewh.ieee.org/soc/nps/nmisc/YIMISAward.html

2. Young investigator's award, first prize, 51st Society of Nuclear

Medicine Annual Meeting, Philadelphia, PA, 2004.

3. Young investigator's award, second prize, 49th Society of Nuclear

Medicine Annual Meeting, Los Angeles, CA, 2002.

Grant Support

. NIBIB 1K99EB007620, "Three-class ROC analysis for task-based medical

image quality assessment," PI: X. He. Priority score:132, 2007-2009.

. FDA contract "Webpage for sizing an MRMC trial", PI: X. He, 2010.

Academic Activities

. Journal Reviewer - IEEE Transactions on Medical Imaging, 2006-

Medical Physics, 2006-

IEEE Transactions on Nuclear

Science, 2007-

IEEE Transactions on Knowledge and Data Engineering,

2008-

BMC Medical Informatics and

Decision Making, 2008-

Journal of the Optical Society of America A, 2008-

Statistics in Medicine, 2009-

. Associate editor - Medical Physics, 2010-

. Professional Societies - IEEE member, 2002-

SPIE member, 2006-

Medical Image Perception Society Member,

2007-

. Invited Lectures

< "Toward Practical Three-class ROC Analysis," University of Chicago,

Oct. 22nd, 2007.

< "Three-class ROC Analysis - a General Decision Theoretic Solution,"

FDA, Apr. 4th, 2009.

Publications

Peer-reviewed Journal Papers:

1. X. He, J. A. Fessler, and E. C. Frey, "Regularized image reconstruction

algorithms for dual-isotope myocardial perfusion SPECT (MPS) imaging

using a cross-tracer prior", in press, IEEE Transactions on Medical

Imaging.

2. X. He and E. C. Frey, "Observer performance on myocardial perfusion

SPECT: effects of quantum noise and patient variations," Phys. Med. Biol.

55, 4949-4961, 2010

3. X. He, B. D. Gallas, and E. C. Frey, "Three-class ROC analysis -- toward

a general decision theoretic solution," IEEE Trans Med Imaging, vol. 29,

p. 206, 2010.

4. X. He and E. C. Frey, "The Validity of Three-Class Hotelling Trace (3-

HT) in Describing Three-Class Task Performance: Comparison of Three-Class

Volume Under ROC Surface (VUS) and 3-HT", IEEE Transactions on Medical

Imaging, vol. 28(2), 185-193, 2009.

5. X. He and E. C. Frey, "Application of three-class ROC analysis to task-

based image quality assessment of simultaneous dual-isotope myocardial

perfusion SPECT (MPS)," IEEE Transactions on Medical Imaging, vol.

27(11), 1556-1567, 2008.

6. X. He and E. C. Frey, "Toward Realistic and Practical Ideal Observer

(IO) Estimation for the Optimization of Medical Imaging Systems," IEEE

Transactions on Medical Imaging, vol. 27(10), 1535-1543, 2008.

7. X. He and E.C. Frey, "The meaning and use of the volume under a three-

class ROC surface (VUS)", IEEE Transactions on Medical Imaging, vol. 27

(5), 577-588, 2008.

8. X. He and E. C. Frey, "An optimal three-class linear observer derived

from decision theory," IEEE Transactions on Medical Imaging, vol. 26 (1),

77-83, 2007.

9. X. He and E. C. Frey, "Three-class ROC analysis - the equal error

utility assumption and the optimality of three-class ROC

surface/hypersurface with the ideal observer," IEEE Transactions on

Medical Imaging, vol. 25(8), August, pp. 979-986, 2006.

10. X. He, C. E. Metz, J. M. Links, B. M. Tsui, and E. C. Frey, "Three-

class ROC analysis - a decision theoretic approach under the ideal

observer framework," IEEE Transactions on Medical Imaging, vol. 25(5),

pp. 571-581, 2006.

11. X. He, J. M. Links, B. M. W. Tsui and E. C. Frey, "Comparison of 180-

degree and 360-degree acquisition for myocardial perfusion SPECT with

compensation for attenuation, detector response, and scatter: Monte Carlo

and mathematical observer results," Journal of Nuclear Cardiology, May-

Jun,13(3):345-53, 2006.

12. X. He, E. C. Frey, J. M. Links, and B. M. W. Tsui, "Comparison of

penetration and scatter effects on defect contrast for GE and Siemens

LEHR collimators in myocardial perfusion SPECT - a simulation study,"

IEEE Transactions on Nuclear Science, vol. 52(5), pp.1359-1364, 2005.

13. X. He, E. C. Frey, J. M. Links, K. L. Gilland, W. P. Segars, and B. M.

W. Tsui, "A mathematical observer study for the evaluation and

optimization of compensation methods for myocardial SPECT using a phantom

population that realistically models patient variability," IEEE

Transactions on Nuclear Science, vol. 51, pp. 218-224, 2004.

14. Y-W Yang, J-C Chen, X. He, B. M.W. Tsui, "Evaluation of respiratory

motion effect on myocardial perfusion SPECT using a set of realistic

phantoms", accepted, IEEE Transactions on Nuclear Science.

15. J. Tang, T-S Lee, X. He, W. P. Segars and B. M. W. Tsui, "Comparison of

3D OS-EM and 4D RBI-MAP-EM reconstruction algorithms in cardiac motion

abnormality classification using a motion observer" accepted, IEEE

Transactions on Nuclear Medicine.

Invited Review Papers

1. X. He and Eric Frey, "ROC, LROC, FROC, AFROC - an Alphabet Soup",

Journal of American College of Radiology, in press, 2009.

Papers in preparation:

1. X. He, "Rationality of ROC analysis".

2. X. He, "2D Three-class ROC surface vs. 5D Three-class ROC surface".

3. X. He, "A sequential decision model for three-class ROC analysis".

4. X. He, "ROC Analysis as a normative practice".

Conference Presentations, Proceedings and Abstracts:

1. X. He, E. C. Frey, W. P. Segars, K. L. Gilland, B. M. W. Tsui, "An

improved phantom population for evaluation of myocardial perfusion SPECT

imaging," Journal of Nuclear Medicine, vol. 43, pp. 9p-10p, 2002.

2. X. He, E. C. Frey, J. M. Links, K. L. Gilland, W. P. Segars, B. M. W.

Tsui, "Evaluation and optimization of compensation methods for myocardial

SPECT using a set of realistic phantoms that include patient

variability," IEEE Medical Imaging Conference (MIC), conference record,

M3-121, 2002.

3. X. He, E. C. Frey, J. M. Links, K. L. Gilland, and B. M. W. Tsui, "An

observer study comparison of 180-degree and 360-degree acquisition for

myocardial perfusion SPECT with compensation for attenuation, detector

response, and scatter," Journal of Nuclear Medicine, vol. 44, pp. 141p-

142p, 2003.

4. X. He, E. C. Frey, J. M. Links, K. L. Gilland, W. P. Segars, and B. M.

W. Tsui, "Effect of anatomical and physiological factors and compensation

methods on observer performance for defect detection in myocardial

perfusion," Journal of Nuclear Medicine, vol. 44, pp. 112p-112p, 2003.

5. X. He, E. C. Frey, J. M. Links, X. Song, B. M. W. Tsui, "Comparison of

the penetration effect on defect contrast for GE and Siemens LEHR

collimator in myocardial perfusion SPECT - a simulation study," IEEE

Medical Imaging Conference (MIC), conference record, M11-263, 2003.

6. X. He, Z. Zhu, and R. Goldberg, "Sound wall," Rehabilitation Engineering

& Assistive Technology Society of North America (RESNA), 26th

International Annual Conference, Atlanta, GA, 2003.

7. X. He, E. C. Frey, J. M. Links, and B. M. Tsui, "Three-class ROC

analysis and three-class Hotelling observer for dual-isotope myocardial

perfusion SPECT (MPS) optimization and evaluation," Journal of Nuclear

Medicine, vol. 45, pp. 42p-42p, 2004.

8. X. He, E. C. Frey, J. M. Links, and B. M. Tsui, "Describing three-class

task performance: three-class volume under ROC surface (VUS) and three-

class Hotelling trace (3-HT) as figures of merit," IEEE Medical Imaging

Conference (MIC), Rome, Italy, 2004.

9. X. He, E. C. Frey, J. M. Links, and B. M. Tsui, "Three-class Hotelling

observer and its application to the evaluation of simultaneous dual-

Isotope myocardial perfusion SPECT (MPS) imaging," Journal of Nuclear

Medicine, vol. 46, pp. 205p-205p, 2005.

10. X. He, E. C. Frey, J. M. Links, and B. M. Tsui, "Equivalence of percent

correct on a 3-alternative forced choice task and volume under the 3-

class ROC surface," IEEE Medical Imaging Conference, Puerto Rico, 2005.

11. X. He, J. M. Links, and B. M. Tsui, and E. C. Frey "Three-class ROC

analysis - decision theoretic approaches," Medical Decision Making Annual

Conference, 2005.

12. X. He and E. C. Frey "Optimal observer framework and categorization

observer framework for three-class ROC analysis," Proc. SPIE, 6146,

61460B, 2006.

13. X. He, J. M. Links, B. M. Tsui, and E. C. Frey, "Channelized Hotelling

observer study of myocardial perfusion SPECT: effects of quantum noise

and patient variation when using OSEM algorithm," Journal of Nuclear

Medicine, vol. 47, pp. 460p-461p, 2006.

14. X. He, X. Wang, X. Song, and Eric C. Frey, "Investigation of optimal Tc-

99m injected activity in dual-isotope myocardial perfusion SPECT imaging

using 3-class ROC analysis," IEEE Medical Imaging Conference, M16-2,

2006.

15. X. He and E. C. Frey, "Describing three-class task performance: three-

class linear discriminant analysis and three-class ROC analysis," SPIE

Medical Imaging Conference, 2007.

16. X. He and E. C. Frey, "Comparison of decision theoretic three-class ROC

analysis and ordinal three-class ROC analysis", MIPS XII Conference,

2007.

17. X. He, B. S. Caffo and E. C. Frey, "Markov Chain Monte Carlo (MCMC)

based ideal observer modeling using a parameterized phantom and a pre-

calculated database," SPIE Medical Imaging Conference, 2007.

18. X. He, B. S. Caffo, E. C. Frey, "Toward Realistic Ideal Observer (IO)

Estimation - an IO Estimation Method for a Realistic SPECT Imaging

Simulator and a Cardiac Torso Phantom", IEEE MIC, 2007.

19. X. He and E. C. Frey, "Three-class ROC analysis - a sequential decision

model developed for the diagnostic task of simultaneous dual-isotope

myocardial perfusion SPECT imaging," SPIE Medical Imaging Conference,

2008.

20. X. He, J. A. Fessler, and E. C. Frey, "Regularized Image Reconstruction

Algorithms for Dual-isotope Myocardial Perfusion SPECT (MPS) Imaging

using a Cross-tracer Edge-preserving Prior", Society of Nuclear Medicine

Annual Meeting, 2008.

21. X. He and E. C. Frey, "Regularized Image Reconstruction using a Dual-

tracer/modality Prior", IEEE MIC, accepted for oral presentation, 2008.

22. X. He, K. Drukker, J. Brankov and Eric Frey, "Three-class

Classification for Binary Decision Making", AAPM, Los Angeles, CA, 2009.

23. X. He and E. C. Frey, "Revisiting the General Three-class ROC Theory",

MIPS, Santa Barbara, CA, 2009.

24. X. He, B. D. Gallas, E. C. Frey, "Three-class ROC analysis - the

general decision theoretic solution", IEEE MIC, Orlando, FL,2009.

25. D. Devakumar, X. He, and E. C. Frey, "Comparative Assessment of ESSE

and DEW Scatter Compensation Methods for Myocardial Perfusion SPECT,"

IEEE Medical Imaging Conference, 2007.

26. X. Wang, X. He and E. C. Frey, "Optimization of Tc injected activity in

simultaneous dual-isotope myocardial perfusion SPECT imaging using a

three-class channelized Hotelling observer study", Society of Nuclear

Medicine Annual Meeting, 2007.

27. J. Tang, W. P. Segars, T-S. Lee, X. He, B. M. W. Tsui, "Optimization of

a 3D cardiac motion estimation method using simulated gated SPECT

images", Society of Nuclear Medicine Annual Meeting, 2007.

28. L. Volokh, X. He, E. C. Frey, B. M. W. Tsui, "Quantifying the

sensitivity/resolution tradeoff for task based collimator optimization

using three-class ROC analysis," IEEE Medical Imaging Conference, M03-2,

2006.

29. B. M. W. Tsui, E. C. Frey, L. Volokh, K. L. Gilland, C. Liu, X. He and

S. Chen, "Effect of object variability in observer performance studies

for image assessment," IEEE Medical Imaging Conference, M03-1, 2006.

30. C. Liu, B. M. W. Tsui, J. Xu, X. He, and E. C. Frey, "Evaluation of

rotation multi-segment slant-hole SPECT mammography with respect to

planar scintimammography in terms of breast lesion detection using the

Channelized Hotelling observer," Journal of Nuclear Medicine, vol. 46,

pp. 111p-112p, 2005.

31. X. Song, E.C. Frey, X. He, W.P. Segars, and B.M.W. Tsui, "A

Mathematical Observer Study for Evaluation of a Model-based Compensation

Method for Crosstalk in Simultaneous Dual Isotope SPECT," IEEE Medical

Imaging Conference (MIC), conference record, M9-4, 2003.

32. Y. W. Yang, J. C. Chen, X. He, B. M. W. Tsui, "Evaluation of effect of

respiratory motion on myocardial perfusion SPECT using a set of realistic

phantoms," Society of Nuclear Medicine Annual Meeting, 2008.

33. X. Wang, X. He, Katsuyuki Taguchi, Douglas Wagenaar, and Eric C. Frey

"Uniformity Correction in Photon-counting X-ray Detector Based on Basis

Material Decomposition", IEEE MIC, 2008.

34. K. Drukker, X. He, Eric Frey and Maryellen Giger, "Potential of Three-

Class Classification in Computer-Aided Diagnosis for Breast Ultrasound",

RSNA, 2008.

35. L. Cheng, X. He, J. Fessler, and E.C. Frey, "A 4-D Maximum a Posteriori

(MAP) Reconstruction Method for Improved Dose Volume Histogram

Estimation", SNM, 2010, accepted.

36. M. Ghaly, X. He, Y. Du, G. Fung, E. C. Frey "Optimization of Energy

Windows for Dual-Isotope Simultaneous-Acquisition Myocardial Perfusion

SPECT using Ideal Observer and Realistic Background Variations."

Submitted to MIC 2010.

37. L. Cheng, X. He, Wesley E. Bolch, G. Sgouros, E. C. Frey, "A convergent

regularized SPECT reconstruction algorithm using anatomical prior for

improved dose-volume histogram estimation," Submitted to MIC 2010.

Xin He

Ph.D. in Biomedical Engineering

Email: abhq05@r.postjobfree.com

Tel:410-***-****

Contact this candidate